
Moffuging Sephiroth
17.6K posts

Moffuging Sephiroth
@uberbasado
Sober





Brian, for the love of god, you cannot take a health database, click 'sort' and think that the top 5 drugs patients who survive longer happen to be taking are causal to the benefit those patients received. 500k is actually not a large cohort for a database, needs alpha correction, was very unlikely to be prespecified, etc. that's why no one is impressed with these studies and they're published in trash journals. this study showed a slight increase in CV events with PDEs vs placebo pubmed.ncbi.nlm.nih.gov/14529061/ the mechanistic rationale is not there and your explanation is terrible. ALL PDEs metabolize cAMP/cGMP, thats why they are phosphodiesterases. are you suggesting we should inhibit all PDEs?! by the same logic we should all be taking ERAs too. why not ARBs and ACEs? screw it i'll take inhaled treprostinil too. might extend my life. then i'll run SQL queries on health databases until i see a 'signal', bonferroni may roll in his grave but i will be vasodilated.






turns out social media stops being interesting once you have an actual life


Today, I’m releasing never before seen intelligence revealing new evidence of past US government funding for more than 120 biolabs in over 30 countries, including Ukraine. In support of President Trump‘s Executive Order to end federal funding of dangerous gain of function research around the world, and increase transparency and accountability, ODNI will continue working with partners across the Administration to identify where these labs are, what pathogens they contain, and what “research” is being conducted. odni.gov/index.php/news…


1/ My nighttime erections are better than the average 18 year old, but Cialis is unlikely to play a meaningful role in them or even my sexual function. While it’s true that daily low-dose Cialis (2.5–5 mg) can help men with erectile dysfunction (ED) or benign prostatic hyperplasia (BPH) by maintaining steady blood levels of the drug, the primary benefit is in restoring minimal normal erectile function, not enhancing already healthy sexual performance. In one study, men with ED taking 5 mg/day of tadalafil showed an average increase of 17.75 minutes in nightly Duration of Erectile Episodes (DOEE). This threshold was considered predictive of a successful response. My dose is half that, 2.5 mg. However, this effect is likely limited to individuals with existing ED, as the drug appears to normalize function, not boost it. Even then, the increase is relatively modest, less than 10% compared to my typical nighttime erections lasting over 3 hours. Another study found that 12 weeks of 5 mg/day tadalafil had no significant effect on the duration of nighttime erections, though participants reported increased confidence and improved spontaneous morning erections.


I take Cialis, but not for sex. It’s actually a longevity medicine. Cialis (Tadalafil) is great for the same reason it gives you fantastic erections… it improves blood flow. Studies show that Tadalafil… + 34% reduced all-cause mortality + 27% reduced major heart disease + 34% reduced stroke + 32% reduced dementia It has also shown benefit in insulin sensitivity, metabolic health, and reduction of body fat. Women have blood vessels too, so theoretically they'd get the same longevity upside. The research is thinner, but early signals are promising. It’s sad that when men and women could benefit from it can miss out because it’s taboo. My protocol is 5mg daily and I've been on it for about two years. *Observational research shows associations, not causation. Outcomes may be influenced by underlying differences in study populations. This is not medical advice and is shared for informational purposes only.




At a time when billionaires and corporate interests wield enormous power over our economy and political system, Congress needs leaders who will stand with working people and take on the oligarchy. Join me and @ZohranKMamdani for a get out the vote rally in Brooklyn on Thursday.







I take Cialis, but not for sex. It’s actually a longevity medicine. Cialis (Tadalafil) is great for the same reason it gives you fantastic erections… it improves blood flow. Studies show that Tadalafil… + 34% reduced all-cause mortality + 27% reduced major heart disease + 34% reduced stroke + 32% reduced dementia It has also shown benefit in insulin sensitivity, metabolic health, and reduction of body fat. Women have blood vessels too, so theoretically they'd get the same longevity upside. The research is thinner, but early signals are promising. It’s sad that when men and women could benefit from it can miss out because it’s taboo. My protocol is 5mg daily and I've been on it for about two years. *Observational research shows associations, not causation. Outcomes may be influenced by underlying differences in study populations. This is not medical advice and is shared for informational purposes only.













