Silvia von Karstedt

Thrilled to share our latest paper in Cell Death Discovery! 👉 doi.org/10.1038/s41420… Together with my fantastic co-senior and co-corresponding author @vonKarstedtLab , we uncovered that the BTK inhibitor ibrutinib has a previously unrecognized role in disrupting redox balance and priming DLBCL cells for ferroptosis. We show that ibrutinibchemically scavenges glutathione (GSH) and represses GPX4 translation, thereby amplifying lipid ROS and triggering ferroptotic cell death. This defines ferroptosis as a mechanistic foundation for additive therapy in aggressive and apoptosis-resistant DLBCL. This was a truly collaborative effort, driven by the exceptional first author Anuschka Langpape. Deep thanks also to all authors and our brilliant collaborators across Cologne for their creativity, hard work, and committment. #Ferroptosis #DLBCL #CellDeath #RedoxBiology #BTK #Ibrutinib #CancerResearch #Oncology #TeamScience #CellDeathDiscovery

Thrilled to share our latest paper in Cell Death Discovery! 👉 doi.org/10.1038/s41420… Together with my fantastic co-senior and co-corresponding author @vonKarstedtLab , we uncovered that the BTK inhibitor ibrutinib has a previously unrecognized role in disrupting redox balance and priming DLBCL cells for ferroptosis. We show that ibrutinibchemically scavenges glutathione (GSH) and represses GPX4 translation, thereby amplifying lipid ROS and triggering ferroptotic cell death. This defines ferroptosis as a mechanistic foundation for additive therapy in aggressive and apoptosis-resistant DLBCL. This was a truly collaborative effort, driven by the exceptional first author Anuschka Langpape. Deep thanks also to all authors and our brilliant collaborators across Cologne for their creativity, hard work, and committment. #Ferroptosis #DLBCL #CellDeath #RedoxBiology #BTK #Ibrutinib #CancerResearch #Oncology #TeamScience #CellDeathDiscovery

🚀 Thrilled to announce the launch of Phase 2 funding for #SPP2306! After an incredibly productive first phase, we’re ready to push the boundaries of 🔬 science. Huge thanks to everyone for the inspiring discussions and groundbreaking ideas—let’s keep the momentum going! 🔥🔥

🎉 Congrats to @DeshwalSoni from @langer_lab on receiving the prestigious ERC Starting Grant! Her groundbreaking research on mitochondria's role in ferroptosis will pave the way for new insights into cell death and disease. 🌟🔬 #ERCStG @ERC_Research buff.ly/3XvV7CH