Wack
19.1K posts
Wack
@wack700
more of a biotech bro. check out extended bio 👇
California, USA Katılım Haziran 2022
813 Takip Edilen3.3K Takipçiler
Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th.
This may be a first-in-human observation.
Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary).
Also, like most things biology: the results are complicated.
My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers.
Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well).
3 days following my second dose (first dose 25 mg, second dose 28 mg)
. Motility: dropped 51%
. Total count: almost unchanged, dropped by 2%
. Total motile count: dropped 52%
. Normal morphology: dropped by 50%
20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts
Motility: recovered back to -2% of pre-psilocybin baseline:
. Total count: dropped by 38%, latent effect.
. Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop)
. Morphology normalized to -10% of baseline levels.
Reduction in free testosterone might have contributed to the effect.
While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose.
In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side).
This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers.
General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset. Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist.
A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.
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@FreightAlley Get ready, Craig. The trucking industry will be the first to feel it.
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@bryan_johnson interesting. thanks for providing us with this information. here i wonder if the most healthy sperm survive these events.
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> be me
> born in 1996 near the city where Unit 731 happened
> at 18, dropped out of school and became a Thiel Fellow, youngest person to publish papers and Forbes 30u30, blah blah balh
> last 12 months "married" He Jiankui who went to jail in China for gene editing human embryos (broke up 2 months later)
> got banned from China
> was homeless for 5 months
> started a company called "Manhattan Project" in literally Manhattan to gene edit embryos
> many interviews and hit pieces
> shut down the company this morning because co-founder conflict
now I'm back in the lab
Jaynit@jaynitx
>be Alexandr Wang >born 1997 in Los Alamos, New Mexico >yes, that Los Alamos >where they built the bomb >both parents are physicists >immigrated from China >meet at a national lab childhood: >coding by age 10 >not games, real projects >science competitions, math olympiads >the trajectory is obvious early >MIT is the only question 2015: >go to MIT >study computer science >but school is too slow >already working at Quora on the side >meet Lucy Guo there >both see the same thing >AI needs data >lots of data 2016: >drop out of MIT after one year >you're 19 >co-found Scale AI with Lucy Guo through Y Combinator >the pitch: AI models need labeled data >images, text, video, all need human annotation >someone has to do this at scale >you will the insight: >everyone's building AI models >nobody's building the data infrastructure >Tesla needs labeled driving footage >OpenAI needs human feedback >self-driving cars need millions of annotated images >you'll be the picks and shovels 2017-2019: >grind quietly >build the labeling platform >hire contractors worldwide >make it fast, make it accurate >Peter Thiel's Founders Fund invests >$100 million >unicorn status at 22 2020: >COVID hits >roommates with Sam Altman during lockdown >two AI guys in quarantine >probably planning the future over breakfast 2021: >Scale AI valued at $7.3 billion >you own 15% >youngest self-made billionaire >age 24 >not a crypto bro >not inherited >built the infrastructure layer the Pentagon: >land defense contracts >U.S. military needs AI >you provide the data pipeline >test and evaluate models for military planning >everyone talks about AI safety >you're actually doing it >for the people with nukes 2023: >testify before Congress >explain AI to politicians >join Expedia board >you're 26 on corporate boards 2024: >launch SEAL: Safety, Evaluation, and Alignment Lab >benchmarks, red-teaming, model testing >if AI is going to be dangerous >you want to be the one testing it January 2025: >Trump's second inauguration >you're in the crowd >write an open letter: "America must win the AI war" >Davos, world leaders, prime ministers >you're 27 meeting heads of state >talking about China, DeepSeek, compute June 2025: >Meta comes calling >$14.8 billion for 49% of Scale AI >you join Meta as Chief AI Officer >step down as Scale CEO >new mission: build superintelligence >with Nat Friedman >both declined OpenAI interim CEO during Altman's ouster >now building the future at Meta the team: >raid OpenAI, DeepMind, everywhere >$100 million signing bonuses flying >Meta Superintelligence Labs >you run it >Zuckerberg gave you the keys the critics: >Yann LeCun calls you "young" and "inexperienced" >one of the godfathers of AI >you're running his old shop >he quit >you stayed from Los Alamos to Meta AI >from data labeling to superintelligence >from MIT dropout to youngest self-made billionaire >from startup founder to Chief AI Officer of a $1.5 trillion company Alexandr Wang. 28 years old. already testified before Congress. already met world leaders. already sold half his company for $14.8 billion. already building superintelligence. the kid from the town where they built the bomb now building the next one. "America must win the AI war." he's making sure it does.
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Is this a Karen or a Zombie?
Running up the car, banging her head on the window. Sounds like Zombie to me!
Oh, and notice the knife in her shaky hand.
What would you do?
1-Wait for police?
2-Drive away?
AmyLouWho@perseverare1776
Watch this white, liberal Karen in her native habitat. Just a few guys duck hunting and she decides it’s her job to save the ducks. Would you have left or stood your ground? Her “bird call” is quite unique😂😂 Sound on for this one, you won’t regret it!!!
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@playmatejaylene fr. it makes me super sleepy. but every now and then 1 or 2 micheladas won't hurt.
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The fortress we are building—and the layers of redundancy—to protect the platform against the AI Slopacalypse will seem obvious in a few months.
Whether we use every tool in our toolkit is TBD, but it would be negligent to not have them ready.
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The financial incentive to spam on X will decline enormously over the next 30 days and soon be negative.
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@InterstellarUAP sometimes i wonder what would happen if elon goes on a trip. but then i stop myself there because what if he never comes back 😟
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🚨 DeWalt Laser Reveals HIDDEN CODE on Walls Under DMT – Proof We're in a Simulation? 😱
Chase Hughes told Shawn Ryan: "A simple DeWalt laser turns into one of the strangest demonstrations of simulation theory you’ll ever see."
"When you look at that, you can see through the wall... You can see through the wall where the laser is."
"While you are in the DMT state, you get close to the wall and you can see code that looks kind of like alien writing... or some that look like kanji Japanese characters."
"This is permanent solid... if you move your head, the code stays in the same place."
"If you put your arm in front of it, the code completely changes, but only right where your arm is."
"The first time I saw it, I wept. I wept."
Multiple people see the exact same code – no explanation!
Mind blown – is reality glitching right in front of us?
Have you ever experienced anything like this on psychedelics?
Do you think we're living in a simulation with visible code?
What would seeing alien-like symbols do to your worldview? Drop your thoughts 👇
#SimulationTheory
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🚨 SOMETHING IS OFF. WATCH THIS CLOSELY. 🚨
One word triggers it.
Both react instantly.
Perfect sync.
That’s not a coincidence.
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