wilco 🌐

@p_maverick_b Do you have any idea the goldmine that is DPW community recycling facilities? Found the 'El Dorado' of ipods.

There was a weird interlude from 2005-2010 where there was a cambrian explosion of handheld single-use electronics before smartphones ate them all. Feels like the same thing is happening with AI tools where people have custom tooling/harnesses/etc before the labs just eat them

"Men w/o work" a fascinating treatise on a shadow pool of displaced labor that doesn't make it into contemporary labor stats by N Eberstadt. Can't recommend enough #BookFriday2026 #Summerreading #audiobooks

@SynBio1 is it implied one cheek is fighting another? 🤔

This on a pair of booty shorts

finished "Blowback" by c johnson on how overreach of empire causes priority restructuring #Books #globaltensions

@ATinyGreenCell this is why I always explain my hobby as crime... then when they tell me to get better at it they realize they may be collateral damage

How many people have had someone tell them they are a fool for not monetizing their hobbies? Anyone get scolded for playing golf without PGA aspirations? What about friends yelling at you for not being in the NBA instead of wasting time shooting hoops at the park? DiYbio, tho...

Love @nfergus work "The Great Degeneration" on destabilizing forces on societies and economies. #books #Socialchallenges

Anyone who takes GLP1 is technically a 'saurian' according to Icke because it was derived from Gila monster lizards. I don't make the rules.

'The Narrow Corridor' by @DAcemogluMIT a slog toward the end (albeit informative) on the 'leviathan' and 'red queen' in context to statecraft. Think that @Peter_Turchin and @HoweGeneration have some concepts to share with one another.

@SynBio1 pray for the llamas sacrificed to moloch for nanobodies 🙏

Man I would not want to be an antibody-druggable drug target right now Big Tech found an accessible use case for AI and they are going to dogpile so many binders on every exposed epitope you wont even be able to see the target anymore

@ThatMrE @SynBio1 the new parental fear mongering over 'looksmaxxing' with synthetic steroids is in full swing. bath salts epidemic remix.

This guy tried to get me to "show him how to inject peptides" ...I said no and to do third party analysis and source from reputable parties. Looks like he was creating a hit piece.

@ProfBuehlerMIT am fascinated with metal catalytic substrates in these models but havent found the corrseponding AI modeling.. does it exist? if so where?

The next frontier in protein design will not be defined by structure alone, but by the capacity to engineer motion as a first-class principle of function. This is because dynamics is where the real biology lives. Foundational work by Karplus, Levitt & Warshel made clear that chemistry cannot be understood without motion, mechanism, and scale. Gō, Brooks & others showed that proteins possess characteristic collective motions - low-frequency normal modes that capture how whole molecules bend, breathe, and fluctuate. Frauenfelder then sharpened the picture further: proteins are not static objects occupying a single minimum, but dynamic ensembles traversing rugged energy landscapes. And yet the modern AI revolution in protein science has been, above all, a revolution in structure. In our new paper in Matter, @_Bo_Ni and I ask a different question: not what structure will this sequence adopt? but what sequence will realize a prescribed pattern of motion? VibeGen inverts the conventional design paradigm. Rather than treating dynamics as a consequence to be analyzed after the fact, it makes dynamics the design objective from the outset. Using a language diffusion model with two cooperating agents - a designer that proposes sequences and a predictor that critiques them against the target motion profile - the system converges on de novo proteins with tailored vibrational behavior. One of the most intriguing results is a form of functional degeneracy - distinct sequences and distinct folds can satisfy the same target dynamical specification. For a given functional pattern of motion, evolution may have sampled only a small region of the physically realizable design space. The space of viable molecular mechanics may be far larger than the repertoire biology happened to discover. We have made "vibe" into a cultural metaphor - something intuitive, affective, subjective. But at the molecular scale, vibe is not metaphor: It is physics. For a protein, the vibe is the pattern of motion itself; the fluctuations, resonances, and collective displacements that determine what the molecule can do.

@SynBio1 whoever figures out the potato avocado (potacado?) is the real winner here. perfect for mashing.

Bioproduct idea precision gene editing to remove individual traits from plants that would otherwise make great crops

brand new grass destroyed so someone can show off daddy's car

@TownofSharonMA our kids sports fields got wrecked by teenagers just before the season starts. vape cartridges and trash everywhere. 😭 #EasterSaturday #EasterMagic

it's really bad. this will take some time to repair and is just obnoxious behavior.

@SynBio1 Fairweather friends. Love to dip their beaks in the publicly funded research but then repackage it and call it 'innovation™️' with a 100x markup and zero cost negotiation.

This amalfi coast cliffside dinner reception just got awkward

Join me and make a gift to Athletics Giving Day 2026 give.brandeis.edu/athletics-givi… Supporting the BDeis athletics program. I've asked them to auction off sections of the track like they were pieces of the Berlin Wall.

@sdamico Used to be Stanford practice to wash out half the class. that would be a kindness compared to continuing on

Talked to someone who graduated Stanford last year — 1. said that grade inflation was so out of control that much of the class has a 3.9+ because professors just hand out A+’s now. 2. said they made majors like chemE dramatically easier by removing required “hard” classes

Finished "Pharmanomics" by @nickdearden75 on the asymmetric power in the drug #Pharma industry post #Covid. Lots of systemic issues. #bookclub

@diananakunda44 easy. long run with the kids to the park by the waters edge.

@willabe_13 It’s so good to just get out and enjoy the moment sometimes. What’s your favorite way to spend a Saturday when you aren't working? ☀️

Come join me for some 5K shenanigans for St Pattys at Mick Morgan's. This is the most celebration you'll get out of me because I can't 'put 'em away' like when I was younger. runsignup.com/Race/MA/Sharon…