Yoav Shaul

@Avraham_Stav זו בדיוק הנקודה הבעייתית. לא עצם העמידה על ההלכה, אלא הבחירה להסתתר מאחורי ‘מה לעשות, זו ההלכה’. זה שיח שמאפיין גישה חרד״לית, ולכן האכזבה גדולה דווקא מצוהר, שממנה ציפו למורכבות ולשיח ולא לסיסמה (שהיא לא בהכרך נכונה)

היו מי שראו בסאגה של ארגון רבני צהר אתמול הוכחה לכך שאי אפשר לקיים קשרים טובים בין דתיים לחילונים אם לא מוכנים להתקפל. אבל נכון יותר לראות כאן את ההיפך. גם אחרי שלושים שנה של הארת פנים והקשבה, אפשר לא לזוז במילימטר בכל מה שנוגע לשמירת ההלכה. לא התייפיפות כושלת, לא צביעות, רק עמוד שדרה ערכי. תודה הרב עמיחי גורדין, It takes one to know one.

@WalterWChen1 @UTSWMedCenter Congratulations, Walter, great news

Thrilled to share that I’ll be starting my lab as an Assistant Professor and Endowed Scholar in @UTSWMedCenter Molecular Biology Dept this Fall! 🥳 We’ll study #peroxisomes #mitochondria #metabolism via the lens of neonatology👶🏻, a very exciting frontier in medicine! #neotwitter

@KivancBirsoy @shanshanliu1218 @gadmark Congrats Kivanc

Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s4155…

@SaharMelamed @MolecularCell @MeetingRna @RNA_ISR @HebrewU Congratulations Sahar

Do viruses use RNA to rewire bacteria? Yes! In our paper in @MolecularCell we use #RILseq to uncover that phages don’t just encode proteins, they use small RNAs to hijack bacterial DNA replication and fine-tune infection. @MeetingRna @RNA_ISR @HebrewU cell.com/molecular-cell…

@Biochemik2204 @masariklab @Science_MEDMUNI @1LFUK1 @FNUSA_ICRC Great collaboration as always, Michal! 👏 Honored to be part of this excellent review.

Our @masariklab new paper has just been published in Molecular Cancer 👏💪. This review aims to provide a comprehensive overview of the involvement of CAV1 in different modes of cancer cell migration and metastasis. rdcu.be/eMiA6 @Science_MEDMUNI @1LFUK1 @FNUSA_ICRC

@avraham_elitsur @arye_minkov כקורא קבוע של "מקור ראשון" הערכתי את השיחה עם הרב זלמן מלמד. אבל השימוש ב״מו״ר״ מפי הכתב מלמדת על הזדהות שפוגעת באובייקטיביות המצופה מראיון. זה מתאים לביטאון ישיבתי, לא לעיתון חדשותי רציני. @MakorRishon

הכתבה שערכתי עם מו"ר הרב זלמן מלמד, יחד עם החברותא הוותיק @arye_minkov, עלתה לרשת. כמה טעימות וקישור בסוף: "הציבור מכבד תלמידי חכמים כאשר הם מכבדים אחד את חברו. אבל כאשר כל תלמיד חכם חושב שרק הדרך שלו נכונה, והציבור רואה שזה מבטל את זה וזה מבטל את זה, היחס לתלמידי חכמים פוחת". >>

@KivancBirsoy @nicoledelgaudio @RockefellerUniv Congratulations Kivanc

New work from our lab describing a role for mitochondrial glutathione in breast cancer metastasis ⁦@nicoledelgaudio⁩ ⁦@RockefellerUniv⁩ aacrjournals.org/cancerdiscover…

@WalterWChen1 @RapoportLab Congratulations Walter

Complementary work also from @RapoportLab nature.com/articles/s4155…

Our paper on discovering a new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein found in > 20 yr) is out in @NatureCellBio! Wonderful, equal collab with Tony Rodrigues, @dwendscheck, Jorge Azevedo, @warscheidlab #ref-CR49" target="_blank" rel="nofollow noopener">nature.com/articles/s4155…

@Biochemik2204 Thank you, looking forward

I'm very much looking forward to your talk Yoav @yoavsha 😊👍

@WalterWChen1 @A_P_S_A @the_asci @AmerAcadPeds Congratulations Walter

Excited to receive an NIH K08 Clinical Investigator Award to support my research on #mitochondria #peroxisomes 😀 The $775K will be critical in helping me transition to independence as I begin looking for a place to start my lab 🙏🏻 @A_P_S_A @the_asci @AmerAcadPeds #neotwitter

@MichaelPacold Congratulations Mike

Just published: nature.com/articles/s4158… Coenzyme Q10 (CoQ10) is critical for mitochondrial function and for controlling reactive oxygen species damage to biological membranes. Because CoQ10 is poorly bioavailable, new approaches are needed to promote CoQ10 synthesis. In our latest paper @Nature, we use CoQ10 headgroup intermediates to restore CoQ10 synthesis in mouse models of HPDL encephalopathy, a rare pediatric neurodevelopmental disease driven by loss of CoQ10 headgroup synthesis. We also use CoQ10 headgroup intermediates to modify the course of this same disease in a patient. Primary CoQ10 deficiencies are rare mitochondrial disorders caused by loss of function of the enzymes that make CoQ10. The neurological symptoms of these diseases respond poorly to CoQ10, likely due to poor bioavailability of this molecule. The newest primary CoQ10 deficiency is HPDL encephalopathy, which is due to loss-of-function variants in the enzyme 4-hydroxyphenylpyruvate dioxygenase-like (HPDL). A few years ago, we discovered that HPDL carries out the first committed step of the mammalian CoQ10 headgroup synthesis pathway, in a study led by Robert Banh @BanhLab: nature.com/articles/s4158… We found that the enzyme HPDL makes 4-hydroxymandelate (4-HMA), the first committed precursor of 4-hydroxybenzoate (4-HB), which generates the CoQ10 headgroup. Patients with HPDL encephalopathy develop spastic paresis, and in severe cases, seizures, neurodevelopmental delay, and death. Mice lacking Hpdl recapitulate these symptoms and die by 15 days after birth. We find that treatment of Hpdl-/- mice with 4-HMA or 4-HB significantly improves the survival of mice from days to years. We treated a single patient with loss-of-function HPDL variants with 4-HB, with dramatic improvement in his symptoms. Thanks to co-authors including Robert Banh @BanhLab and Sota Kuno @kuno_sota, editors George Caputa @curiousdrgeorge and Victoria Aranda @mvicaracal, and reviewers including @RutterLab and everyone at @NYULangone @nyugrossman who made this work possible! Many thanks to our collaborators, Roy Sillitoe @BCMHouston / @TexasChildrens and Alex Joyner @MSKCancerCenter. Grateful for funding from @DamonRunyon @PershingSqFdn @psscra @MindPrize @AmericanCancer @HarringtonDI_UH @OHRareDisease @NIH.

@PeggyPHsu Congradulation Peggy

So honored to receive a BWF CAMS and thankful to all of my mentors and supporters along the way! BWF Announces 2025 Career Awards for Medical Scientists bwfund.org/news/bwf-annou…

@rushika_perera @Nature @GillesRademaker Congratulations Rushika

Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇

@JasonRCantor @NatMetabolism @kyle_flickinger Congratulations Jason

excited to share our latest work now online @NatMetabolism, led by @kyle_flickinger, where we unravel a mechanistic basis for the conditional essentiality of NADK, one of the many interesting hits from our previously reported CRISPR screening with HPLM rdcu.be/ekpu6

@Gerta_Hoxhaj @NatureCellBio @DohunKim96 Congratulations Gerta

Thrilled to share our new @NatureCellBio paper, led by our amazing student @DohunKim96: Mitochondrial NADPH powers mitochondrial fatty acid synthesis to sustain lipoylation, mitochondrial translation, and oxidative metabolism. rdcu.be/eiyH7

@mayur_g_tanna @IMRIC_HUJ @Hujimed @HebrewU @HebrewU_heb Great work and presentation Mayur.

I thank my mentor Prof. Yoav Shaul @yoavsha @IMRIC_HUJ @Hujimed at The Hebrew University of Jerusalem @HebrewU @HebrewU_heb for raising me as a prospective scientist in the field of cancer metabolism.

I am very delighted to express that I have defended my hashtag#PhD hashtag#seminar on 24th March 2025. This doctoral journey not only honed my scientific caliber but also shaped me as a patient, focused, resilient, and mature human being.

@RobertoZoncu @aakritijain24 @rushika_perera @OlzmannLab Congratulations Roberto

Excited to share ‘Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins’, by phenomenal superstar postdoc Aakriti Jain @aakritijain24 and amazing collaborators @rushika_perera, Guido Bommer, Charly Craik and @OlzmannLab: science.org/doi/10.1126/sc…

@LironBarPeled @Nature Congratulations Liron

I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @Nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and

@SharonShle @SpringerNature Congratulations Sharon

Check out my latest #research on #cultivated_meat scaffolds, published with @SpringerNature in NPJ Science of Food: rdcu.be/ebd9y

@abu_remaileh @Stanford_ChEMH Congratulations Monther