RecombinationNation

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RecombinationNation

RecombinationNation

@zeroinputag

The only truly renewable resources are biological diversity and human creativity. Let's cross pollinate them to make a new tomorrow. Weekly podcast and blog

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RecombinationNation
RecombinationNation@zeroinputag·
@robinhanson Didn't we already ruin scientific progress by turning academia into a metric chasing bureaucracy?
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RecombinationNation@zeroinputag·
Buying someone a chocolate bar then telling them about the child slavery behind it while they eat it is the modern equivalent of being the serpent in the garden of Eden spreading knowledge of good and evil to the naive.
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RecombinationNation
RecombinationNation@zeroinputag·
@Andercot Given the diversity of unculturable prokaryotes and invisible viruses recently discovered with DNA screening, there may well be rare life forms without the standard DNA-ribosome-protein operating system right under our noses.
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Andrew Côté
Andrew Côté@Andercot·
Every animal on Earth unpacks using the same DNA-mRNA-Ribosome architecture Every animal is a proteomic program executed from a single molecule of instructions Likely this architecture is universal throughout the cosmos
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RecombinationNation@zeroinputag·
@ATinyGreenCell In controlled tests during WWII unimproved Typha produced more food calories than the best maize by several fold. We drained all the swamps in the midwest to make room for more maize because we lacked a method to harvest it.
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Sebastian S. Cocioba🪄🌷
Sebastian S. Cocioba🪄🌷@ATinyGreenCell·
@zeroinputag issue is our agroeconomy is corn-shaped. its a lot more than just novelty to make it work. nothing fixes sunlight into calories like corn. nothing.
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Sebastian S. Cocioba🪄🌷
Sebastian S. Cocioba🪄🌷@ATinyGreenCell·
What percent of the latest generation of US citzens want to seriously become farmers?
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RecombinationNation
RecombinationNation@zeroinputag·
Not sharing details of my life on here has started to feel more satisfying than the alternative.
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RecombinationNation
RecombinationNation@zeroinputag·
@nullbotto When I first did watermelon variety trials I was eating a >5kg fruit almost every day. Managed to give myself a mild case of gout.
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Nick Jikomes
Nick Jikomes@trikomes·
A lot of people who say they’re after health and longevity are primarily interested in *looking* younger for longer, so they can continue to get certain kinds of attention for longer. Confronted with the choice between doing something they believe will make them appear younger for longer, versus something that might benefit health without the perceived appearance benefit, they will reliably choose the former. Someone like Madonna got all that plastic surgery because she believed it would make her look younger, for longer. Her root desire was to keep harvesting a certain kind of attention from people. Her desire for that attention was strong enough to convince her that she had sufficient knowledge to successfully achieve her goal by putting that knowledge into practice. Many would say her beliefs backfired, that she doesn’t look younger and more attractive. She didn’t actually posses the level of practical knowledge she thought she had to achieve her goal. Johnson believes he and his team have sufficient knowledge of biology to render him immortal. To the extent that’s true, they will prioritize whatever promotes longevity, whether or not it makes him LOOK younger. To the extent his root desire is like Madonna’s, to LOOK a certain way in order to harvest attention, they will filter and warp the available science to rationalize doing things they believe will make him LOOK a certain way, whether or not those things provide true longevity benefit. From our earliest days as infants to final days before our inevitable deaths, the basic currency of human desire is the same: attention. The amount and kind of attention someone wants predicts their behavior better than the stated reasons for their actions. Will Mr. Johnson’s umbrella actually help him live longer? Is that his ultimate goal, or is his root desire attention?
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Jack@Jackkk

Bryan Johnson reveals why he uses an umbrella even when it’s not raining and UV levels are low “90% of physical skin aging is from the sun, so this is a UV umbrella protecting me”

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RecombinationNation
RecombinationNation@zeroinputag·
@nullbotto You need to track down some lines with restored fertility. Mark Reed in the USA developed an interesting population- I interviewed him on Going to Seed way back.
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Stupid sweet potato flowers senesce and fall off right after they're pollenated
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Sasha Putilin (curious irrationalist)
me: “I don't think scorpions are Team Consciousness. They are the most annoying replicators ever. Why do you say they each deserve a Wikipedia page?” @algekalipso: “Because they are all you — the same experiental field — just twisted in a bad attractor”
Captain Pleasure, Andrés Gómez Emilsson@algekalipso

Lates post from the trenches of QRI's Tepoztlán 2026 Research Retreat :D (featuring @webmasterdave - @QualiaRI) [this one is an effort-post - enjoy!] --------- ~excerpt~ Why a utilitarian makes life sacred David said the thing that reorganized the conversation for me. I had been needling him, pointing out that “whatever it takes” runs straight into trade-offs and cost-effectiveness, that his worldview was meeting a hard constraint, that he sounded less like a utilitarian and more like a priest. He answered without flinching. On strict negative-utilitarian grounds, he said, the best route to minimizing suffering is to enshrine in law the sanctity of sentient life, human and nonhuman. The claim is exact and worth keeping in his terms. The sanctity of life is a legal fiction adopted on consequentialist grounds: given the frailties of human nature, treating sentient life as inviolate yields better outcomes by the negative utilitarian’s own criteria than any regime that lets you weigh each killing on its merits. He grants that treating Darwinian malware like us as though it were sacred can stick in the craw, and he reads the twentieth century as decisive evidence that the legislative framework is wise anyway. Philosophers call this indirect utilitarianism. David notes, accurately, that indirect negative utilitarianism just collapses back into negative utilitarianism, so he is endorsing the plain article. Sit with how strange and how correct that is. A man whose foundational commitment is the abolition of suffering, who would in principle weigh any life against any other, arguing that we should hard-code life as near-inviolable into our institutions. The resolution is that the hard rule is the utilitarian move. This is two-level thinking of the kind R. M. Hare described. At the critical level you may reason in pure consequences, but the disposition you want running in fallible agents at the intuitive level is a near-absolute reverence for life, because agents who price each killing case by case produce far worse outcomes than agents fenced in by a bright line. The bright line is a Schelling fence. Permit case-by-case killing on utilitarian grounds and the category of permissible killing erodes under motivated reasoning until it has swallowed things no honest ledger would have allowed. A society visibly precommitted to the sanctity of life is more trustworthy and lower-variance, and spared the slow arms race of ever more elaborate justifications (following the letter rather than the spirit of the rules). The sacredness is load-bearing social technology, and a utilitarian who understands game theory should want it installed and should want it to feel like more than a calculation, because a reverence you can switch off when convenient is no constraint at all. This is also, David likes to point out, why he flew the Jain banner rather than the Buddhist one. The Buddha did not think like a lawyer. The ambiguity over whether monks could eat meat offered as alms handed self-serving rationalization its opening, and the result is that less than half the world’s Buddhists are even vegetarian. The sanctity-of-life rule is an attempt to leave rationalization no such opening. It is the lawyer’s instinct turned to mercy. The shape recurs in law and in karma alike. The law attaches harm to a named actor who must answer for it, and the karmic ledger attaches it to a mind that must carry it. The sanctity-of-life norm belongs to the same family, insisting that even a justified killing leaves a mark. Each is a refusal to let the cost of an act quietly vanish, and the refusal is wiser than any single calculation that would override it. Now return to where we began. If we would beg a superintelligence to keep us, cognitively humble and occasionally dangerous as we are, inside the circle of compassion, then how I treat the scorpion tonight is a rehearsal for the norm I want encoded in whatever succeeds us. There is a hard-nosed version of this in current AI safety, the proposal that we install reverence for all sentient life as a core constraint in artificial agents, and a constraint we visibly keep ourselves is far more credible than one we merely recommend. The stick in my hand and the alignment of a future mind rhyme, because both turn on what the strong owe the weak when the weak can do nothing whatsoever to enforce it. And it settles the reprogram-or-retire question in the direction David has argued for decades, the same direction as the Herbivorize Predators project he advises. Confronted with a vicious scorpion or a vicious human, the abolitionist chooses reform over retirement. You do not exterminate the species or execute the man. You relocate the individual tonight, and over the longer arc you reach for fertility regulation by immunocontraception, for obligate carnivores genetically and behaviourally tweaked into harmlessness, for an ethic of compassionate stewardship in place of the snuff-movie logic of orthodox conservation biology (don’t pretend “conservation biology” is morally neutral - it’s laden with background philosophical assumptions that are highly dubious when examined carefully). High-tech Jainism is the refusal to retire anyone, scaled up and down the whole ladder of minds, and held to even on the nights when retirement would be cheaper. ----- The micromort backbone For years my mental hygiene has run on actuarial tables and on pricing activities in micromorts, where one micromort is a one-in-a-million chance of death. I tell the language models to be absolutely pedantic, to assume I am neurodivergent and want multiple decimals, and not to round anything off for my comfort (I’m the kind of person who actually cares about orders of magnitude). They (sometimes) oblige with beautiful, well-researched, actuarial-like tables. I once had a model design my daily walk this way (and I suggest you do similarly). Given map data, per-street collision counts, and crime (mostly phone-snatching) statistics in different street segments, it found a roughly micromort-minimizing 45-minute route that also happens to pass a store, because the small hit of dopamine from going to fetch something raises the odds I actually take the walk, and the walk itself buys back a couple micromorts through exercise against the long-tail risks of a bus or a mugging. On certain blocks the same analysis just says: looks empty, but a lot of phones get taken here, pocket your phone. None of that is visible while you stand on the corner, and the careful statistic-driven analysis often gives you counterintuitive results (did you know about 1 percent of deaths in the United States are the result of car crashes?). This is the backbone I want under the policies at a retreat. The pitch to attendees is simple: some of these rules will feel counterintuitive, and what they do is shave down the bulk of the likely harms and clip the long tails at once. For the scorpions there are two questions and they have opposite answers, so it pays to separate them. The first is how likely a sting is at all. The official statistics are no help, because they are drawn from a profile that is the photographic negative of ours: small children, men carrying and stacking firewood, homes with free-range hens and stored corn and palm-leaf or sheet-metal roofs, and, tellingly, people who take no action to prevent stings at all. We are eleven numerate adults in masonry-and-tile houses who sweep with UV, check our shoes, and keep the beds off the wall. But our house is also visibly dense, five on the garden walls in three minutes and eight or nine indoor sightings (including the one next to a bed) in three weeks, so the honest input is our own observed encounter rate rather than the national average. Run that through, and without any protocol the group faces roughly a coin-flip, call it a 45 percent chance that someone among the eleven is stung over the two months. With the layered protocol that roughly halves, to something like 20 percent. Around 99.8 percent of any sting that might happen would, at worst, be very painful rather than a medical emergency. Scorpions sit outside the Schmidt sting pain index, which only rates bees, wasps, and ants, but the bark-scorpion sting is well documented: an immediate burning hit followed by intense throbbing and hours of hypersensitivity to touch, comfortably above the honey bee that anchors Schmidt at a 2, and nothing like the bullet ant at the top.

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🇦🇺Craig Tindale
It’s not that complex. A civilisation either retains the ability to transform matter at every layer of the chain, or it slowly becomes dependent on those who do. That's a simple axis there’s nothing wrong with that as long as you can trust the people that you become dependent on but if you do it outside partners who share your security outlook then the risk naturally rises The West spent thirty years believing finance, software and consumption could substitute for industrial continuity. But wealth is downstream of conversion capacity. If you cannot refine it, smelt it, machine it, tool it, transport it and manufacture it, then eventually you do not control it. We rent access to somebody else’s system and that carries a lot of embedded risk.
Jawwwn@jawwwn_

,@PalmerLuckey on Peter Thiel, @pmarca, and raising venture capital: "People say, 'It's so difficult to get a warm intro to people.'" "Marc Andreessen has a really good point on this." "He says, 'You know the reason that I want a warm intro for anybody that I'm going to invest in? Because if you can't get anyone in my network—if you can't get any of the 10,000 people with my phone number to say a nice word about you, and you can't track down anyone dumb enough to connect you with me—why would I talk to you? That's part of the test.'" "I was a 19-year-old kid working a minimum wage job with no college degree, living in a 19-foot camper trailer—and Peter Thiel gave me a million dollars when nobody else would to start Oculus." Via @HooverInst

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Richard D. Bartlett
Richard D. Bartlett@RichDecibels·
the local swallows are getting to know me
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RecombinationNation@zeroinputag·
@bryan_caplan In my mind the army of white walkers overrun Westeros, then the children of the forest emerge from their underground lairs to reclaim their homeland, and the cycle of magical crushing winters ends, so long as Essos leaves them alone. Kill any character who doesn't flee.
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Bryan Caplan
Bryan Caplan@bryan_caplan·
GoT could have been saved as late as season 8, episode 3. Crucial edit: The dead should have triumphed at Winterfell, killing most of the heroes, and forcing the survivors to go to Cercei hat in hand. Then in episode 5, Euron saves the day by using his ballistas on the undead dragon... then immediately turns them on the living dragons. That leaves Arya to assassinate Cercei in the final episode, ideally as part of a Valkyrie-style master plot. You could even still have Drogon torch King’s Landing. He’s the sole surviving dragon, and his wing’s wounded so he has to go on foot. When the Lannister forces try to give him death by a thousand cuts, Dany *believably* goes berserk. Who sits the Iron Throne at the end? Anyone but Bran the Catatonic!
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no@nullbotto·
People always mention ducks when you mention snail and slug problems, but why can't I have crabs roaming the garden, eating up the snails?
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Nick Jikomes
Nick Jikomes@trikomes·
What do I mean by "house of cards"? Why do I emphasize carefully reading the papers that other papers cite? Let's look at an example from nutrition science. Image 1: The paper below is a meta-analyses (study of studies), looking at over a dozen clinical trials with more than 300,000 patients total. Sounds impressive, right? It's been cited nearly 800 times, and commonly described as "very high quality evidence" that replacing saturated fats with polyunsaturated fats is good for health. Conclusion of the meta-analysis: "These data provide support for current recommendations to replace saturated fat with polyunsaturated fat (PUFAs) for primary prevention of CHD." But... what happens if you don't just stop reading a the abstract, assuming that Very Serious People did Rigorous Science? Hmm... Image 2: Out of all the trials they looked at, MOST trials did NOT show a significant benefit of replacing saturated fats with PUFAs. The entire conclusion of the paper rests on just 2-3 trials that are weighted the most heavily. Let's look at the single most heavily weighted trial. It's weighted heavily (counts the most) in this meta-analysis, so it must be a VERY good trial, with rigorous methods.... right? Wrong. The trial with the largest sample size (HPFS trial; n=41,082). How did they measure food intake? Well, they didn't actually measure it. They guessed. Image 3: They asked middle-aged males to fill out a 131 item questionnaire about what they ate LAST YEAR. People testifying in murder trials, where someone's life is on the line, often give unreliable testimony of events they witnessed. But in "nutrition science," researchers ask 50-year-old dudes to tell them what they ate last year, from memory, and do statistics on it. Three follow-up questionnaires were sent every two years after that. In other words: middle-aged men had to remember everything they ate in a year and researchers took their word for it. They then CALCULATED (i.e. guessed) the nutrient content of the food people SAID they ate in the *past.* They actually did do some "validation." How? In a tiny sub-sample of people (n=127), they compared calculated intake cooked up by researchers with what subjects reported during two diet records taken six months apart. Linoleic acid is one of the major dietary fats that matters here, the most common PUFA in seed oils. The correlation between calculated linoleic acid and what was reported in diet records was a measly r=0.37. Keep in mind: *NONE* of this involved actual measurements of nutrient content. No one was measuring the mass of food people ate, taking a sample of it, and literally measuring its content. THAT pitiful data was what was inside the most heavily weighted clinical trial in the meta-analysis. What about the second most heavily weight trial? That one had n=84,566 people. Huge sample. Must be a great study, right? Let's take a look at the Methods section... Wait a minute. The meta-analysis says the sample size of this trial was n=84,566, but the trial abstract says it's n=78,778. Maybe it's a typo? Oh well, let's see how they collected the data... Image 4: More memory tests, this time for middle-aged women! They asked people to remember what they ate last year, once every FOUR years. They then CALCULATED the nutrient content by ASSUMING the food people said they ate had identical nutrient content to a USDA food composition database. Hooray, we're doing SCIENCE! The two trials above were weighted most heavily in the original meta-analysis we looked at. The data inputs are absurd. If you threw out these trials, the main results of the meta-analysis would disappear. House of Cards
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Nick Jikomes@trikomes

It's only because I'm no longer in academia that I have enough time to carefully read more of the literature. What do you find when you carefully read more papers, and the papers they cite? A house of cards. Not only do researchers fail to read all of the papers they cite, they sometimes don't even know what was (incorrectly) written in the papers they themselves wrote.

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@zeroinputag Stuffed pickles would be intense
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breeding cucumbers large enough to make pickle burger buns
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