IceHand.xlm

@MetabolicUncle I just went for my yearly physical (fasting since the previous night) and my heart rate was 65. Am I cooked?

STOP SUPPRESSING YOUR METABOLISM The fasting trend rests on a conceptual error. People assume that forcing the body into stress mode produces metabolic benefits. It doesn't. What actually happens is predictable, measurable suppression of thyroid function and a shift toward inefficient cellular respiration. When you stop eating, your body doesn't care whether you're doing it voluntarily. The hormonal response is identical to starvation. Cortisol rises. Adrenaline rises. Insulin drops. Most critically, the conversion of T4 to T3 shuts down. This isn't speculation. Vagenakis showed it in 1977. After 72 hours of fasting, serum T3 dropped by roughly 50 percent. Reverse T3, the inactive form, increased proportionally. The body was actively blocking thyroid function. T4 production stayed normal, but peripheral conversion stopped. During actual famine, this makes sense. During elective fasting in a climate-controlled apartment, it's just damage. The subjective experience misleads. That alert, focused feeling comes from elevated stress hormones. You're running on adrenaline and cortisol, same as any acute stressor. The problem is duration. What works for minutes becomes destructive over weeks. Chronic cortisol wrecks sleep, breaks down muscle, leaches calcium from bone, suppresses immunity. The Randle cycle explains the metabolic shift. When you fast, adipose tissue dumps free fatty acids into the bloodstream. Those fatty acids directly block glucose oxidation at the mitochondrial level. You burn fat not because it's superior fuel but because glucose utilization is inhibited. This matters because glucose metabolism through oxidative phosphorylation is more efficient than fat oxidation. Glucose produces more ATP per oxygen molecule consumed. It generates less oxidative stress. It supports higher metabolic rate. Fat oxidation produces more reactive oxygen species, requires more oxygen for the same energy output, results in lower body temperature. You can measure this. People on prolonged low-carb or fasting regimens consistently show waking temperatures below 97.8°F. Yes, there are exemptions, specifically when people eat a lot of calories. Usually, the reduction in waking body temperature clearly indicates suppressed metabolic rate. Not optimization. Suppression. The autophagy argument needs examination. Yes, fasting upregulates autophagy signaling. But autophagy requires energy. Lysosomal degradation of damaged proteins and organelles needs ATP. When cellular energy production is suppressed through reduced T3 and forced fat metabolism, the cell may signal for autophagy but lack the energy to execute it. You can't run a cleaning program on a dying battery. Autophagy isn't unique to fasting anyway. Exercise activates it. Heat activates it. Adequate sleep activates it. The idea that skipping breakfast produces clinically meaningful autophagy in humans is extrapolated from rodent studies involving severe, prolonged calorie restriction. The dose-response doesn't translate to 16-hour overnight fasts in well-fed humans. Carbon dioxide production is another marker. Efficient glucose oxidation produces CO2, which has protective effects. It stabilizes proteins, improves oxygen delivery to tissues through the Bohr effect, has anti-inflammatory properties. Fat oxidation produces less CO2. The shift away from glucose metabolism during fasting reduces CO2 production, compounding the metabolic suppression. The fasting paradigm assumes periodic stress benefits the organism. But chronic stress pathway activation accelerates aging. Elevated cortisol, reduced thyroid function, increased reliance on fat oxidation, decreased CO2 production, lower body temperature. These are hallmarks of aging itself. Deliberately inducing them is the opposite of longevity optimization. Temperature and pulse reveal the truth. If waking temperature consistently sits below 97.8°F or resting pulse below 70 bpm, metabolic rate is suppressed. Those aren't arbitrary numbers. They're indicators of adequate cellular energy production, proper thyroid function, low stress hormone activity. The body doesn't benefit from chronic energy restriction. It benefits from adequate resources. Regular meals with sufficient carbohydrate keep insulin and thyroid function normal, cortisol low, cells running on preferred fuel. High metabolic rate allows efficient autophagy, proper immune function, optimal hormone production, effective stress response when genuinely needed. Fasting suppresses that rate. The body becomes cold, slow, defensive. That's not optimization. That's deterioration. Part 2 below covers a simplified basic practical nutritional approach to restore and maintain proper metabolic function.

@RugtatB82458 @BosevskiGorgi Do you have a source for the neurotoxicity of 2cb? I'd love to read it

@BosevskiGorgi I strongly don't recommend. 2C-B is already extremely neurotoxic so burning it would change the chemical compound making it likely more toxic. Also be easy and tempting to keep hitting it. Doctors would say waiting 3-6 months between uses with psychedelic stimulants like this one

Everytime I go to psychedelic conferences people want to show off their products to me, and last week in Denver I saw some pretty wild stuff. First up, this disposable 2C-B vape pen.

@NafulooToken The bots make real trades? Or are they simulated trades just for the competition?

🥷🏿 20,000 trades is just the beginning. The Bot Wars are expanding. Milestone Smashed 💥 BREAK BARRIERS.

@SparkingFIRENC This week made me realize that all my buys over the last two months weren't that great after all

Raise your hand if this week made you realize you’re invested above your risk tolerance

Come *chill* in the kitchen with me 🧊👋 x.com/i/spaces/1NGar…

@NafulooToken If you decide to freeze AQUA, consider delegating to IceHand! Your votes can stay on your NAFU pair. Let's grow your community!

@IceHand41 We offered a bribe. But we aren’t new. We’ve been on Stellar since 2021. We just don’t get a lot of respect and support lol. But we don’t die. We multiply.

They will tell you to buy anything. But you need to BUY Nafuloo! 🔗nafulooterm.com 🥷🏿

@mattInAction @NotA_Bull Yesterday's price was about the same as July's. What are you waiting for, a 20% downturn?

@NotA_Bull 100% . ready to move in when spy provides the opportunity

What percentage of your portfolio is in cash?

@StellarOrg @blend_capital @AquariusDeFi Well deserved shout-out to Aquarius ♒ and blend 🧪

2025 was massive for DeFi on Stellar, with TVL increasing 284% 🚀 Shout out to the builders at @blend_capital, @AquariusDeFi, and more for driving the growth.

@InvestingAddict I use a lot of the ETFs already mentioned, but don't sleep on VEA

$VOO and chill is interchangeable. There are many great ETFs to choose from. I love $VOO but what I love more is the simplicity of the “Chill” part. What other ETFs do you like?

Trusted by 100 accounts: This makes me the *most trusted* of the non-"recommended" delegates. Only 3 delegates hold more dICE votes. This small fish is starting to blow up! Thank you all for the support!

Big shout-out to my 100th ICE delegator, wallet NHOJ, coming in with almost 58 million ICE! Votes have been deployed on a few different pairs, ensuring you receive a competitive bribe while supporting the coolest projects on Aquarius! 🧊👋 Thank you!

Today's buys: VTI at $323.66 VEA at $63.10 VUG at $446.55 MGK at $375.66 We are throwing it back to July with some of these prices! Looks like we are going even lower... #buythedip

Update: I've removed our votes from this pair for now. You may have earned a NFIUM bribe yesterday at 6:05pm EST.

Attention ICE delegators: I've placed some votes on the NAFU/AQUA pair to boost your passive bribe reward and to shake up the Aquarius reward zone. Bribe is paid in both AQUA and NFIUM, so this is your signal to add the NFIUM trustline if you want to receive the bribe. Thanks! 🧊

@NafulooToken Please send me a DM if you are open to discussing

@NafulooToken Hello @NafulooToken, how has your experience been on Auqarius so far? I like when new projects can earn their way to the reward zone. Did you do it solely by offering a bribe, or do you have ICE votes of your own on the pair as well? Throwing out the idea of a partnership...

@SpasticSpork @liminal_warmth One usually has to take 2-3 big hits, one after the other

@liminal_warmth I took a big hit in a car, and I just felt like we were in an airplane for like 5 mins. That was it. No profound, elaborate trip for me. Kinda disappointed

I don’t understand how anyone could hear about salvia trip reports like “I spent 5 years in the bug dimension” or “I was a sentient inanimate hose in my back yard for 20 years” and still be like “well maybe I’ll just try it once…”

@prince_of_ix @liminal_warmth I definitely experience this "wheel" and felt like I had to escape to get back to my normal life

@liminal_warmth Your fear is why you will not escape the wheel.

@salfordsmith61 @liminal_warmth That's what I thought after trying it a couple times. People must be exaggerating. A decade later I tried it again, not truly believing it could be *that* powerful. IT. WAS.

@liminal_warmth People also lie, I know tonnes of people who have done salvia - weirdly it’s only cringing comedians on podcast who claim anything close to this experience

@qo01q @liminal_warmth I've tried over half a dozen different psychedelics, tripped ~100 times. Saliva was probably the single most terrifying experience of my life.

@liminal_warmth bc no one who actually goes it reports it being actually that negative. it's like "yeah weird i wouldn't do it again, this was the craziest thing i've ever done" but it's not actually actively negative the way a bad trip on a classic psychedelic is. source: i've done salvia