Tristan Farmer

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Tristan Farmer

Tristan Farmer

@001TMF

AI for programmable biologics & protein design | Building biological intelligence | Longevity & personalised therapies | GitHub: 001TMF | UoE

Присоединился Şubat 2026
67 Подписки269 Подписчики
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Tristan Farmer
Tristan Farmer@001TMF·
Gene therapies exploding —> oligo supply chain struggling —> bottleneck DNA distribution through restricted KYC access —> better supply for training data? Most suppliers already have biosecurity protocols.
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Milo Smith
Milo Smith@mil000·
I BOUGHT ANOTHER PRO DISPLAY XDR
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Tristan Farmer
Tristan Farmer@001TMF·
Has anyone gotten notable results having access to wearable health data. Like what am I supposed to do with it.
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Ivan D. Rueda
Ivan D. Rueda@ivandjrueda·
@001TMF Totally. Also its super short-sighted, anyone with enough interest could obviate such gates using some recombinant DNA techniques before NA synthesizers became more efficient.
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Tristan Farmer
Tristan Farmer@001TMF·
At this point, this biosecurity letter feels like pure theater a repeat of Mythos and Glasswing. create the issue, then pass the liability If it’s a real problem, more paperwork isn’t the solution.
MTS@MTSlive

SITUATION DETECTED: Sam Altman, Dario Amodei, and Demis Hassabis have signed a joint open letter calling on Congress to mandate screening of synthetic nucleic acid orders, citing AI’s rapidly improving ability to assist with biological research as an urgent biosecurity risk.

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Tristan Farmer
Tristan Farmer@001TMF·
@kevfly16 Difference is 1 advances in benchtop oligo printing and 2. Oligo fragmenting. Additionally this would most likely slow down actual R&D especially considering the supply chain problems with DNA.
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Kevin Flyangolts
Kevin Flyangolts@kevfly16·
@001TMF I agree that protecting the data and knowledge is very hard if not impossible and likely not good for the world. Anyone with enough interest can also make tons of their own fertilizer or ammonium nitrate yet we monitor and screen customers of those products
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Tristan Farmer
Tristan Farmer@001TMF·
Agentic Bio will change how drugs are discovered. I’m not talking about orchestration. Reasoning has increased our success rate significantly.
Tristan Farmer tweet media
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Malika 🧬
Malika 🧬@malikules·
"we lack the biological data to train our models. therefore, we must extract it, by force, from every entity that has it. and once we have bled them dry, we will crush them into the dirt, leaving nothing but the pristine, suffocating illusion of our own benevolence"
Andrew Curran@AndrewCurran_

Sam Altman, Dario Amodei, Demis Hassabis and many others have signed a letter urging Congress to increase security on orders of synthetic nucleic acids - and the equipment needed to make them - as models continue to become increasingly bio-capable.

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1752vc
1752vc@1752vc·
30+ investors you can talk to today 👇 VCs @lucasjpols - @1752vc @Trace_Cohen - Six Point Ventures Claire Cherry - Era VC Tobias Bauer - TBVentures @DrewBailer - Fiat Ventures Ohad Tzur - Venture Forward Adam Bo - A12i Nikhil Choudhary - Nirman Ventures Sébastien Gros - Headline & Will Bruno Villetelle - VU Ventures Olivia O'Sullivan - Forum VC James Roycroft-Davis - Evio Colin Gardiner - Yonder Ethan Austin - Outside VC Leon Eisen, PhD - Network VC Pablo Srugo - Mistral @BrandonHoffman_ - @SunsetVC Dylan Kaplan - Alumni VC Etienne Boutan - Intuition VC Kenneth Kashif Thomas - BackFuture VC Sam Merullo - UpsideDown VC Ankur Sethi - Winner Capital Shane Ray Martin - B Ventures Chris Tottman - Notion Capital David Y. - Ethos Fund Jahn Karsybaev - Big Sky @ItsElanaGold - Two Roads Angels @mdantus @xlehmann @gambino @joningib
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Tristan Farmer ретвитнул
Matthew F. McKnight
Matthew F. McKnight@matt_f_mcknight·
Andrew, I signed, this is important work - but we need to be really careful to not get distracted from the bigger problem of rapidly decentralizing capabilities to create / deploy biothreats. Detection, identification, response - globally and persistent/pervasive - should be the top priority. DNA synth will be distributed, it won’t be centralized in a way that can be effective with this approach. Desktop, at home, new synthesis tech coming, etc. Not to mention we can’t regulate China, etc. and this is a globally distributed technology. This kind of legislation is sort of like telling people not to write viruses on all their home computers or, worse, if they do we will monitor them all to see what they type (which people would get around of course). Important now, not practical in medium/long run. Necessary to reduce some risk, not nearly sufficient… nor where our top priorities should be. Only practical thing is to make detection and response work great, global, and fast. e.g. - The "finger in the dike" refers to the classic legend of the "Little Dutch Boy" who selflessly plugs a small leak in a dam with his finger, holding back the sea to save his town from a devastating flood. Small, temporary stopgap to a major, escalating problem.
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Tristan Farmer
Tristan Farmer@001TMF·
@ebetica Kinda want to try to see if our biological reasoning approach could boost the success rate.
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Zeming Lin
Zeming Lin@ebetica·
This protocol was validated in our paper with minibinders and scfvs against 5 hard therapeutically relevant targets. We validated this protocol with BLI, live cell immunofluorescence, functional assays, and cryoem structures. It's not about how many binders you can design, it's about whether they'll work in the lab.
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Zeming Lin
Zeming Lin@ebetica·
How to design your own PD-1 binder in 4 easy steps: 1. Download the tutorial notebook from the ESM team 2. Get a @modal API key to scale it up 3. Scaling it up, O($1000) will get you a 96 well plate of minibinders with >50% success rates on typical targets 4. Test it in the lab!
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Tristan Farmer
Tristan Farmer@001TMF·
All the people doing protein interaction predictions. With the release of openBind, why not train a model on that, then fine-tune it on PPI?
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Tristan Farmer
Tristan Farmer@001TMF·
Rebranding the term employee to agent. Now we are 100% agentic.
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Tristan Farmer
Tristan Farmer@001TMF·
@boazbaraktcs Bit pointless. First, no pledge to actually support nucleotide producers just passes on the burden. Second, this technology is so widely available that it likely slows the good actors more than it slows the bad ones.
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Boaz Barak
Boaz Barak@boazbaraktcs·
Proud to have co-signed this letter. Bio capabilities of AI systems, including foreign and open source ones, are fast advancing. We can't assume that bad actors will not have access to such capabilities and need to ensure information is not the only bottleneck.
Alec Stapp@AlecStapp

No one should be able to order a bioweapon through the mail. @IFP & @JoinFAI are proud to co-lead an open letter calling for mandatory DNA synthesis screening & recordkeeping. Signatories include: - Sam Altman, CEO & Co-Founder, OpenAI - Dario Amodei, CEO & Co-Founder, Anthropic - David Baker, Director, Institute for Protein Design; 2024 Nobel Prize in Chemistry recipient - Patrick Collison, CEO & Co-Founder, Stripe - Paul Graham, Founder, Y Combinator - Demis Hassabis, CEO, Google DeepMind; 2024 Nobel Prize in Chemistry recipient - Emily Leproust, CEO & Co-Founder, Twist Bioscience - Lawrence Lessig, Roy L. Furman Professor of Law and Leadership, Harvard Law School - Gerald W. Parker, former Special Assistant to the President for Biosecurity and Pandemic Response - Mustafa Suleyman, CEO, Microsoft AI - Alex Tabarrok, Professor of Economics, George Mason University - Alexandr Wang, Chief AI Officer, Meta; Founder, Scale AI - Christine E. Wormuth, President & CEO, Nuclear Threat Initiative; 25th Secretary of the Army Read the letter and see the full list of signatories: screendna.org Many DNA synthesis companies voluntarily screen orders to mitigate biosecurity risks, but no law requires them to do so. Leaders in AI, biotech, life sciences, national security, and the nucleic acid synthesis industry agree that Congress should act to strengthen safeguards against biological threats. @deanwball put it well in the WSJ: “If you’re synthesizing the stuff that yields biological life and viruses, we’re asking you to screen to see whether it is dangerous in some way. That seems like a reasonable thing for society to insist upon.”

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