The Agami Lab

The new @CancerGrand Challenges teams have just been announced! Read about the teams tackling cancer avoidance, mechanisms driving mutational signatures, the dark proteome, cancer neuroscience, and rewiring cancer cells now in @CD_AACR: aacrjournals.org/cancerdiscover…

Team ILLUMINE, featuring our Hannon Group, will receive up to $25m over five years to take on the challenge of the dark proteome as part of Cancer Grand Challenges. Full story: cruk.cam.ac.uk/news/hannon-gr…

We are hiring! Come and work with us from aberrant mRNA translation to innovative treatment opportunities. #agamilab #Bioinformatics #NKI nki.nl/careers-study/…

Online now: Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation dlvr.it/TH8WR8

Please have a look to our new publication in Immunity. cell.com/immunity/fullt… (@ImmunityCP )!

Hopefully more T cell Receptor will be identified and more clinical applications will follow. A big thanks to the all Agami Lab and to our collaborators and fundings that have been essential to achieve this work. @JOlweus @oncodeinstitute @NKI_nl

It has been a long journey since we first uncovered defective translation in cancer upon amino acid shortage in 2019 and today where we have been finally able to target cancer cells by adoptive T cell therapy against those aberrant peptides.

We are happy to announce that our group is among the three groups from the @NKI_nl that will receive the prestigious @ERC_Research Advanced Grant! This grant will support our goal of detecting and exploiting changes in the protein landscape of cancer. ➡️ bit.ly/4aMY4mi

We are thrilled to enounce the selection of our principle investigator Reuven Agami as a new member of @_knaw for his "series of highly original and high-impact discoveries"! lnkd.in/d9PxWRnq

Congratulations to @abhipataskar42 for being awarded the highly prestigious annual AvL prize for the most talented young researcher of the NKI. We are all very proud👏

We are excited to share our recent review published fresh in Molecular Cell. It highlights recent advance on various protein diversification events by mRNA translation in cancer. #cancer #molecularcell #AcademicTwitter #mRNAtranslation #Cell cell.com/molecular-cell…

A great Research Highlight by @lisa_heinke on our recent publication.

How well do we understand the complexity of the transcriptome? in our new study (@AgamiLab, @alkan_ferhat, @liamfaller, and more), we uncover an unexpected function of cleavage and polyadenylation, which generates thousands of novel uncapped mRNA isoforms! authors.elsevier.com/sd/article/S10…

We are looking for a talented Postdoc fellow to investigate "sloppiness" in mRNA translation in cancer. More details are below. #academicjobs #postdoc #CancerResearch #sciencejobs

@abhipataskar42 @Jchmpg @JOlweus @BarbMarte @michal_bassani We also thank Pavel Baranov and John Atkins for their excellent news and views article, which can be read here; nature.com/articles/d4158…

We are very happy to share our recent paper published in Nature. We show that IFN-signaling associated Trp depletion leads to a new class of antigens, i.e Substitutants. Thank you @abhipataskar42 @Jchmpg @JOlweus @BarbMarte @michal_bassani and others.

We have a postdoc position in bioinformatics at our group at NKI, Amsterdam. Please have a look for more details #nki #oncology #Bioinformatics nki.nl/careers-study/…

#LIDLbyLIDL: ⁦@LidlNederland⁩ is making a statement, I suggest we all follow; they are the only supermarket I will shop at. nos.nl/l/2399906

Lidl, one of the largest supermarkets chains in the Netherlands, stops selling cigarettes and tobacco. Good move by the German chain. nos.nl/artikel/239990…

Online Now: Oncogene-dependent sloppiness in mRNA translation dlvr.it/S8QmC0