Friedrich Fauser (@f_fauser) - Профиль Twitter

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We are thrilled to reveal @SangamoTx‘s Modular Integrase (MINT) platform at #ASGCT2024. Our MINT platform is a protein-guided genome editing method designed to facilitate targeted integration (TI) of synthetic DNA into chromosomal sites. PDF: sangamo.com/science/public… [1/10]

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Sangamo Therapeutics@SangamoTx·16 Eyl

🧬🚀 We’ve made substantial progress in development of our modular integrase, or MINT, platform- a gene editing method that we believe will enable large-scale genome engineering. Our updated manuscript which showcases these advances is available on bioRxiv bit.ly/41Y14ud

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Friedrich Fauser@f_fauser·16 Eyl

Thrilled to share this update on bioRxiv: biorxiv.org/content/10.110… >10x activity, T cell data & genome-wide specificity evaluation!

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Friedrich Fauser@f_fauser·9 May

We are thrilled to reveal @SangamoTx‘s Modular Integrase (MINT) platform at #ASGCT2024. Our MINT platform is a protein-guided genome editing method designed to facilitate targeted integration (TI) of synthetic DNA into chromosomal sites. PDF: sangamo.com/science/public… [1/10]

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Martin Jonikas@JonikasLab·19 Ara

We are excited to share 71,700 new #Chlamy mutants from the CLiP2 collection pre-publication! Nearly-saturating genome coverage. Please note: new background strain, mating type, and antibiotic resistance. Read: biorxiv.org/content/10.110… Search and order: chlamylibrary.org

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Martin Jonikas@JonikasLab·10 Ağu

Excited to share our latest preprint! Biogenesis, engineering and function of membranes in the CO2-fixing pyrenoid biorxiv.org/content/10.110…

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Friedrich Fauser@f_fauser·31 Tem

Thanks @FremontFire for putting this Niles Canyon fire out quickly and @FremontPD for patrolling the neighborhood :)

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Friedrich Fauser@f_fauser·19 Tem

@pituvilarnadal @NatureComms @Dinnenylab @JonikasLab Congrats Pep! Excited to see what comes next :)

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Josep Vilarrasa Blasi@pituvilarnadal·18 Tem

After a mere blink in the cosmos -3 years as a preprint- our paper has found its home in @NatureComms . Thanks to all coauthors, the long supporting journey @Dinnenylab, and collaborators @JonikasLab and Michael Sussman. Oh, and by the way, I'm job hunting!!!

Josep Vilarrasa Blasi@pituvilarnadal

Preprint Alert!! We took a systems biology approach to establish #Chlamy as a simplified system to study osmotic stress pathways and identified conserved pathways across the green lineage, uncovering a new role for actin during osmotic stress acclimation, thread

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Sangamo Therapeutics@SangamoTx·12 Haz

One of our lead scientists, @wraithnot is presenting @FASEBorg about our exciting Modular Integrase (MINT) platform, a new approach to 🎯 integration of large 🧬 constructs into precise locations within the human genome. #genomicmedicine #MINTplatform

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Friedrich Fauser@f_fauser·19 May

@Shanhe_PU @UWBotany @UWMadisonLS @UWMadison Congrats! :)

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Shan He@Shan_He_lab·18 May

I am so excited to announce that I will be joining the Department of Botany @UWBotany at the College of Letters & Science @UWMadisonLS, University of Wisconsin-Madison @UWMadison, as a Tenure-track Assistant Professor starting in January 2025! (1/3)

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Sebastian Arangundy Franklin@SArangundy·17 May

Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of Large DNA Sequences biorxiv.org/content/10.110…

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Jeff Miller@wraithnot·17 May

Our #MINTplatform does not use #CRISPR, #ZincFinger or #TALeffector to 🎯 DNA. Instead, we directly reprogram Bxb1 integrase to go where we want in the human genome. The details are in our @bioRxiv paper: bit.ly/3wwPLwy

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Sangamo Therapeutics@SangamoTx·17 May

We are thrilled to announce the publication of our manuscript detailing the development of our Modular Integrase (MINT) platform #MINTplatform is now live on @bioRxiv! bit.ly/3wwPLwy @f_fauser @gdavis624 @arangundy @wraithnot

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Jeff Miller@wraithnot·11 May

Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of Large DNA Sequences biorxiv.org/content/10.110… - our paper describing reprogrammed serine integrases is now on BioRxiv!

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Tom Ellis@ProfTomEllis·11 May

Cool new preprint from Sangamo, engineering BxbI integrase to target native sites in the genome. Who needs landing pads now?

bioRxiv Synthetic Biology@bioRxiv_synbio

Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of Large DNA Sequences ift.tt/1aEgDKj #biorxiv_synbio

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Sergio Gutiérrez 👨‍🔬🦠🧬@SaGutierrezz·11 May

MINT platform reprograms Bxb1 integrase for precise genome editing. Achieving up to 35% efficiency, it integrates kilobase-sized constructs into specific genomic sites, including human TRAC and AAVS1 loci.🧬👨‍🔬✂️#GenomeEditing #SyntheticBiology #GeneTherapy biorxiv.org/content/10.110…

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Friedrich Fauser@f_fauser·11 May

Now on bioRxiv: Systematic Development of Reprogrammed Modular Integrases Enables Precise Genomic Integration of Large DNA Sequences biorxiv.org/content/10.110… Original Thread: x.com/f_fauser/statu…

Friedrich Fauser@f_fauser

We are thrilled to reveal @SangamoTx‘s Modular Integrase (MINT) platform at #ASGCT2024. Our MINT platform is a protein-guided genome editing method designed to facilitate targeted integration (TI) of synthetic DNA into chromosomal sites. PDF: sangamo.com/science/public… [1/10]

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Friedrich Fauser@f_fauser·11 May

@SArangundy And here is the bioRxiv link: biorxiv.org/content/10.110… Thanks to everyone who showed up at the #ASGCT2024 poster session. Didn't expect this to turn into ~5h of conversations :)

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Friedrich Fauser@f_fauser·9 May

Handle correction: @SArangundy

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Friedrich Fauser@f_fauser·9 May

Please find Greg Davis (@gdavis264), Sebastian Arangundy (@Arangundy), or myself (Poster 1680, Friday) during #ASGCT2024 to talk science; or meet up with Jeff Miller (@wraithnot) during FASEB in Rome! Thanks to everyone who contributed to this project – this was fun 😊 [9/10]

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Friedrich Fauser@f_fauser·10 May

@mchilberg FASEB: events.faseb.org/event/2e6b9882…

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Marty Chilberg@mchilberg·10 May

Tx for excellent recap. When is Miller presenting in Rome?

Friedrich Fauser@f_fauser

Link to our MINT platform presentation and poster: sangamo.com/asgct-2024/ [10/10]

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Sangamo Therapeutics@SangamoTx·9 May

Today at #ASGCT2024 is the platform presentation for our next-generation Modular Integrase (MINT) technology, engineered to enable large-scale genome editing. Learn how the MINT platform utilizes Bxb1, to integrate large sequences of 🧬 into the genome. bit.ly/3QhlQyY