Haley Maria Dourron

@Drug_Researcher @KordingLab You really went deep into the unicorn dimension for this stuff…

Breaking: Two major psychedelic studies are about to change everything when published today. After years of rigorous, double-blind work, there is now the first provable evidence of interspecies communication… and the first laboratory-confirmed psychedelic-occasioned spiritually enlightened humans. Details below.

@schizosemia Don’t know the details but based on those books it seems interesting…

Six years and three drafts later, I’ve got something I can defend.

Do psychedelics feel like psychosis? According to people with experience with both states, for the most part, not really. At least for our participants in general, cannabis felt substantially more like psychosis. link.springer.com/article/10.100…

Someone involved with a psilocybin trial here in Sweden told me that most Swedes think of psilocybin the same as heroin — all drugs are the same here— Yeah, psychedelic exceptionalism is a problem. But this is a bit much.

@bryan_johnson Be careful there are risks. I would guess more than psilocybin…. link.springer.com/article/10.100…

I'm experimenting with 5-MeO-DMT because it may be most underrated longevity molecule no one is talking about. + Accelerated neurogenesis: a single dose more than doubled brain cell proliferation and neuronal regeneration in the hippocampus within 12 hours, alongside measurable increases in synaptic density and firing frequency in rodent models. + Proteomic reorganization: in human cerebral organoids, 5-MeO-DMT triggers rapid proteomic shifts favoring cellular reorganization and synapse formation. Early evidence of structural brain renewal at the molecular level. + Default Mode Network reset: The DMN calcifies with age locking us into rigid, repetitive patterns of thought. 5-MeO-DMT disrupts these patterns, restoring bottom up connectivity between sensory and creative brain regions. A forced return to neurological flexibility and youthfulness. + Systemic anti-inflammation: suppresses pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) while upregulating IL-10, the anti-inflammatory signal. Mediated through the Sigma-1 receptor, suggesting a mechanism distinct from other psychedelics.

New podcast interview with @HDourron at @Furthure707 on ‘Exceptional Experiences with Psychedelics and Beyond’ for all the latest on the far out and freaky end of the spectrum psychedelic experiences.. open.spotify.com/episode/1KngJB…

Please share.

Based on: journals.plos.org/plosone/articl… Featuring @Drug_Researcher iconic handcrafted artwork: pubs.acs.org/doi/10.1021/ac…

Sometimes quotes in papers are just to ridiculous (in a good way)

@BasicMorality You got a killer paper published though recently and more to come :) You are gonna go furthure soon too

Today I woke up to see the guy who plagiarized me is going popular making videos about my theory. The other week, my sister passed away. A few months ago my grandma. My mom is gone too. What is life

@RCarhartHarris @TheProjectUnity There are risks to everything— i would actually be more concerned and trust psych science less if no risk were being found Some people die running if they have during a marathon — even simple things like running can kill people pubmed.ncbi.nlm.nih.gov/8800121/

@TheProjectUnity I'm not as conspiratorial. Sometimes science delivers evidence of a nature that you might not want to hear. The research looks valid to me and will likely publish in a high-impact peer-reviewed journal.

Suddenly, out of the blue, cannabis has new negative side effects that have never been discussed before and now psilocybin apparently gives you brain tumours. Why do I get the feeling that the incentive behind these studies isn't medically orientated?

This is a good preprint. It’s not a big shock that there are risk of HT-2A agonist The risks are most likely only of concern for a really select populations…people with a very rare, terminal cancer. Don’t flip out y’all

@av00idant Never trust a prankster 😂

Prank projects not working

@neuralkn0t Entropic cryptic

Grass is Green

A tolerability trial is really needed to get a solid understanding of risks. Interviews and surveys aren’t gonna do the job. Plus, a trial is much safer than use in the wild Do check this out!

@Iceman_Hof Where is this? I wanna go somewhere like this….

Winter expedition in full swing ❄️

How do psychedelics impact people with a history of non-affective psychosis? A qualitative study (whole, marvelous paper. Brava, @HDourron Haley Dourron et al.) frontiersin.org/journals/psych…

Psych*delics might not be universally harmful for people with psychotic disorders, but more careful studies need to be conducted. Don’t try this at home, folks! Also, the insight into hallucinations is a puzzling piece of data that also fits with a survey study we conducted.

But it wasn’t all life-changing experiences. Some people really didn’t feel like psychs impacted long-term… they were just kind of like, “Whatever, it’s fun!” I’m guessing this experience is more common in psychedelic-using circles than is often acknowledged

For a while, people have wondered what sort of impact psychedelics might have on individuals with a history of psychotic disorders. What might go wrong? Could any potential benefits occur? frontiersin.org/journals/psych…