Harry Fu รีทวีตแล้ว

MAPT p.R406W disrupts autophagy–lysosome pathway, impairing Tau degradation. Mutant neurons accumulate Tau/pTau in lysosomes, impairing motility, fusion, & clearance. Autophagy enhancement lowers Tau & restores degradation but doesn't rescue trafficking nature.com/articles/s4146…
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