

Kidney Cancer
736 posts

@KCA_Journal
Editors-in-Chief: Primo N. Lara Jr., MD, and Peter Mulders, MD | Dedicated to expediting our understanding & improving treatments of kidney cancer




















COSMIC-313: Final OS Analysis @AlbigesL Cabo+Nivo+Ipi (C+N+I) maintains PFS & ORR benefits vs. Placebo+N+I in 1L IMDC intermediate/poor risk aRCC. No OS difference between arms 🧬 High M2 macrophage abundance linked to improved OS with C+N+I #GU25 @asco #kidneycancer #cancer #oncology @dryukselurun @MikeSerzanMD @drenriquegrande @crisbergerot @reginabarcar @DRBakaloudiMD @ReneeSaliby @yekeduz_emre @neerajaiims @PGrivasMDPhD @CParkMD @OncLive @apolo_andrea @tompowles1 @Uromigos @TiansterZhang @ERPlimackMD @OncBrothers















Final #CheckMate9ER results (5+ yr FU: N+C > S in 1L #aRCC PFS HR 0.58, OS HR 0.79, ORR 55.7% vs 27.4%. No new safety signals. N+C remains a SOC for untreated aRCC. @ASCO #GU25 @motzermd @tompowles1 @MSKCancerCenter @OncoAlert





Eye opener discussion @TiansterZhang ASCO GU 2025: Clear Cell RCC – Beyond the Dichotomy 🔬 ccRCC is not a monolith! 🧬 Molecular complexity: VHL, PBRM1, SETD2, BAP1 📊 Transcriptomic clusters & tumor microenvironment drive heterogeneity 🚀 Precision medicine is key! #GU25 @asco #kidneycancer #cancer #oncology @DrChoueiri @dryukselurun @MikeSerzanMD @drenriquegrande @crisbergerot @reginabarcar @DRBakaloudiMD @ReneeSaliby @yekeduz_emre @neerajaiims @PGrivasMDPhD @CParkMD @OncLive @apolo_andrea @OncoBellmunt @sonpavde @MattGalsky @tompowles1 @Uromigos @kalasri3 @TiansterZhang @AndreaNecchi @ERPlimackMD @OncBrothers

1/7 Pleased to share updated OS results from the #TIVO-3 study (NCT02627963), previously presented at #ESMO24. Our analysis focused on outcomes in patients with #ccRCC who had received prior treatment with a checkpoint inhibitor (CPI) - representing 26% of the trial population.






































