LeDoux Lab

Very proud and happy for Rodrigo @LeDouxScience !

New paper: "Induction of conditioned #avoidance via mental #imagery". New article available at Behaviour Research and Therapy, with @G_Mertens, Leer, & Engelhard! (sciencedirect.com/science/articl…)

"defensive responses like fleeing or freezing can co-occur with feelings of fear, not because the neural processes underlying these two kinds of events are intimately entwined in the amygdala, but instead because the events have the same starting point." Completely agree!

Did you ever wonder what happens to memory in Alzheimer's disease? We found that the memory trace is still there, but impaired by interference with other neuronal ensembles. Like a noisy radio channel. Check it out: nature.com/articles/s4159… @DZNE_en @DZNE_de

"Thoughtful Feelings" is a new My Word article in Current Biology. It's an overview of my ideas about what emotions are. Thank you @GeoffreyNorth1 for publishing these "thought pieces." authors.elsevier.com/a/1bCM73QW8Ru7…

Great talk by @hakwanlau at Consciousness Club @WCHN_UCL dealing with which creatures are conscious and ending with suggested clinical treatments for fear and phobia. Thanks to @smfleming for organizing

New preprint from our lab! On our quest to understand how neural activity drives behavior we made a big step forward. Find how we quantify and map DeepLabCut annotated behavior using Deep Variational Autoencoders. VAME GitHub Toolbox available. biorxiv.org/content/10.110…

New preprint from the lab on how the retrosplenial cortex and the superior colliculus help mice find their way home when they are scared. Led by the fantastic duo @RubenDVale and Dario Campagner. #gimmeshelter biorxiv.org/content/10.110…

Confused about confidence? Bored with Bayes? Tired of 2-AFC? Join us for a virtual journal club: Monday May 4th at 12:30 New York time on nyu.zoom.us/j/99274459619 @hsinhungli and I will present our paper on multi-alternative confidence nature.com/articles/s4146…

It's finally out! Congratulations @ArminLak. The paper is here: sciencedirect.com/science/articl… (and it *will* be Open Access -- working on it right now)

New preprint from @candelabellot in @MacAskillAF lab @uclnpp! Push-pull regulation of exploratory behavior by two opposing hippocampal to prefrontal cortex pathways biorxiv.org/content/10.110…

"A cortico-collicular circuit for accurate orientation to shelter during escape"

Excited to share a preprint of the final work from my postdoc lab where we show that prelimbic cortex bidirectionally controls platform-mediated active avoidance. @jorgeiravedra @rojasbowe @JonathanMoranPR @vpvalentin_ biorxiv.org/content/10.110…

#BRAINInitiative virtual event in 1.5 hr on "How Can Dynamical Systems Neuroscience Reciprocally Advance Machine Learning" #machinelearning events.labroots.com/event/BRAIN-In… featuring @rajankdr @KordingLab @xaqlab @nathanieldaw

'The central amygdala recruits mesocorticolimbic circuitry for pursuit of reward or pain'

Looking forward to speaking @StanfordBrain today at 12 PM pacific on "New technologies for neuroscientists (and others" neuroscience.stanford.edu/events/wu-tsai…

Context- and Subgroup-Specific Language Changes in Individuals Who Develop PTSD After Trauma

Amelioration of obsessive-compulsive disorder treated with one epigenetic drug, great job @clemoscatarina !

Our new study with @GordFishell and @JDimidschstein is now on bioRxiv, showing how the ventral hippocampus engages CCK+ interneurons in the prefrontal cortex, with endocannabinoid modulation of inhibition at only a subset of L5 pyramidal cells: @theXL92 biorxiv.org/content/10.110…

Congrats @TinaVoelcker! This is one of those really pretty results I think a lot of folks suspected was true but never confirmed. Until now.