Evan Cross Ray

@hendopolis What did Russian papers say?

INDEPENDENT: Mutiny, Mayhem and Panic on the streets of Moscow #TomorrowsPapersToday

So excited to announce publication of our new research manuscript in @CircRes on “DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension”👇🏿 ahajournals.org/doi/10.1161/CI… Congrats 1st author @ashleylpitzer! Big Thanks to Co-authors

@r_aravinth_ Perhaps the relevant question is whether the chances of saving kidneys are significantly better than chances of ischemia. I doubt the trials included v. heavy proteinuria. Many excluded PAD. Perhaps the horse is out of the barn.

#askrenal 70/M with Diabetes-Severly increased albuminuria.Normal renal function. Has asymptomatic upper extremity PAD and Claudication in lower limbs.Started on DAPA by Physician.Should we stop it?

PPI's in CKD: 3 pts in CKD clinic with PPIs restarted since I held them previously (usu adding an H2B) Indications: GERD (by GI), cough/COPD (by Pulm). None for Barret's or GI erosion. Frustrated my colleagues in other specialties and I are working against ea. other. Thoughts?

#FreeArticleOfTheWeek- L-WNK1 is required for BK channel activation in #IntercalatedCells By: Evan C. Ray, et al. ow.ly/rmKR50GUEKM #AJPRenal #WNK1Kinase @PittDeptofMed @RayRenal @mohd_bataineh @tkleyman @arohan_s

If people wonder why I keep switching patients from short-acting furosemide to longer-acting torsemide, it’s because of the top graph. Green bar above dashed line (na excretion from furosemide) rapidly approaches pink area (compensatory reabsorption)—>0 net naturiesis.

@Jwaitz I wish our EHR had a pop-up warning against daily Lasix dosing.

@ShineboxWarrior @NEJM The fully adjusted model included BMI.

@NEJM Isn't this just another way of stating cov poses a greater risk to the obese? Have to imagine greater the sodium intake greater the likelihood of obesity

In a study involving 10,709 adults, higher sodium intake was significantly associated with higher cardiovascular risk in a dose–response manner with a daily sodium intake of approximately 2000 to 6000 mg. #AHA21 nej.md/3orqk7k

@MaryPrante @NEJM Assuming steady-state, intake = excretion. Generally regarded as a better estimate than, say, food questionnaires or food diaries. Though not as precise as a laboratory-supplied diet, it allows long-term evaluation.

@KRayHSR What a cutie.

"To clean the urine is to clean the soul, and the mind..." youtube.com/shorts/1aw4LRD…

"And what of the urine? Does he still produce that liquid that maintains our feeble balance with nature?" Could have been a scene with one of my medical school attendings. But now I realize... I have become that attending... youtu.be/1aw4LRDKUXM

@kidney_boy Tastes not bad. I agree it's concerning the company is confused about their formulation/content.

Anybody have any experience with RenaMag? It is a magnesium supplement with 150 mg of elemental magnesium. I’m a bit concerned about the sticker to correct the amount of magnesium from 126 to 150 mg.

@askrenal Reading about U.S. nursing shortages due to COVID. cnn.com/2021/06/27/us/… In the past 3 mo, compared to pre-COVID, would you describing in-patient dialysis nurse staffing where you round as:

@Dan_Nash94 I bet the venous K+ was over 8.

Lactate from an athlete after a 1200m time trial... If this was recorded in a hospital they'd already be writing the death certificate!

@LabTouyz gave an outstanding talk on physiology of #magnesium at magnesiumworkshop2021.com. She referenced a shocking study showing change in fruit/veg mineral content 1914-2018. Speaks volumes about contemporary mineral deficiency! dx.doi.org/10.3390%2Fnu10…

Amazing headline from the day after the Tulsa massacre, in which hundreds of black Americans were killed, and 10,000 were left homeless.

@bramaccimmyt @CIMMYT @ACCIMMYT @vmva1950 I didn't realize Zn deficiency was so prevalent. Underscores the importance of @clintoria's work showing that Zn deficiency promotes hypertension - the number one risk factor for disability adjusted life-years globally. doi.org/10.1152/ajpren…

Zinc deficiency is one of the causes of malnutrition that affects 2 billion people. @CIMMYT & its allies developed a new zinc-biofortified wheat that is being spread with the help of seed company partners in Bangladesh, India, Pakistan, Mexico & Bolivia. bit.ly/3gqXeCK

@DrJMLuther @aishaikh @hswapnil @AmJNephrol @kirkcampbell @tkleyman Agree. Maybe too effective. ncbi.nlm.nih.gov/pmc/articles/P…

@aishaikh @hswapnil @AmJNephrol @kirkcampbell Although this study by @RayRenal and @tkleyman may make you a little more cautious sciencedirect.com/science/articl…

Cool mechanistic study of the day (once I can get the full text from @AmJNephrol somehow) karger.com/Article/Abstra… Amiloride and Triamterene reduce proteinuria!

@hswapnil @AmJNephrol Nice. Thought this effect was secondary to inhibition of connecting tubule glomerular feedback (ENaC dependent antagonism of TGF) as shown by Oscar Carretero, @cesarom1 et al. journals.physiology.org/doi/pdf/10.115…