James Gleeson

We show the gut microbiota directly generates auto-antigens by modifying glycosylation of a human glycoprotein (IgA1) in an autoimmune disease called IgA nephropathy. Published @ScienceTM bit.ly/4cw3gwD @DrBenechNicolas @JMChemouny @h_sokol @Inserm @Pharmabiotic @APHP

The bacteria in your gut depend on where you are in the social network. And the microbes within us treat our social networks as the extended environment in which they thrive. They can spread from person to person. New #HNL work out today in @Nature. 1/

Good controls make good science. Thank you to @NicolaMTomas et al. for clarifying their anti-nephrin auto-antibody data with further experiments in this week's @NEJM.

.@ProgressIreland's first plan is about infrastructure. Ireland is about to splurge on infrastructure. But we’re already on the wrong track. Unless we change track, these projects will be slower and more expensive than they need to be. 🧵... progressireland.org/to-save-up-to-…

Nature research paper: In situ targeted base editing of bacteria in the mouse gut go.nature.com/3VW8iuJ

My favourite Mícheál Ó Muircheartaigh quotes: "Seán Óg Ó hAilpín. His father's from Fermanagh. His mother's from Fiji. Neither a hurling stronghold." "The stopwatch has stopped. It’s up to God and the referee now. The referee is Pat Horan. God is God." "Teddy McCarthy to John McCarthy, no relation. John McCarthy to Teddy McCarthy, still no relation." "Anthony Lynch, the Cork corner-back, will be the last person to let you down. His people are undertakers." "1.5 to 0.8 - well, from Lapland to the Antarctic, that’s level scores in any man’s language." "I saw a few Sligo people at Mass in Gardiner Street this morning and the omens seem to be good for them. The priest was wearing the same colours as the Sligo jersey. 40 yards out on the Hogan Stand side of the field, Ciarán Whelan goes on a rampage, and it’s a goal. So much for religion!" "Pat Fox out to the 40 and grabs the sliotar. I bought a dog from his father last week. Fox turns and sprints for goal. The dog ran a great race last Tuesday in Limerick. Fox to the 21, fires a shot, it goes to the left and wide. And the dog lost as well." "He grabs the sliothar. He's on the 50. He's on the 40. He's on the 30. He's on the ground." "Colin Corkery on the 45 lets it go with the right boot. It's over the bar. This man shouldn’t be playing football. He’s made an almost Lazarus-like recovery from a heart condition. Lazarus was a great man, but he couldn’t kick points like Colin Corkery." "Pat Fox has it on his hurl and is motoring well now, but here comes Joe Rabbitte hot on his tail. I’ve seen it all now, a Rabbitte chasing a Fox around Croke Park." "He’s not a big man, he’s not a small man, he’s what you might call a handyman." "Brian Dooher is down injured. And while he is, I’ll tell you a little story. I was in Times Square in New York last week, and I was missing the Championship back home. So I approached a newsstand, and I said, 'I suppose ye wouldn’t have The Kerryman, would ya?' To which, the Egyptian behind the counter turned to me, and he said, 'Do you want the North Kerry edition or the South Kerry edition?' He had both so I bought both. And Dooher is back on his feet."

Thanks to @NatRevNeph for highlighting our work on the microbiota in IgA nephropathy recently published in @ScienceTM. nature.com/articles/s4158… science.org/doi/10.1126/sc…

@hKminski @JulienVPDang @ScienceTM @DrBenechNicolas @JMChemouny @h_sokol @Inserm @Pharmabiotic @APHP Thank you. Open access to the full text is available through Plan S @cOAlitionS_OA at the following website: cri1149.fr/en/publication…

@_JamesGleeson @JulienVPDang @ScienceTM @DrBenechNicolas @JMChemouny @h_sokol @Inserm @Pharmabiotic @APHP Great work Is it possible to have access to the full version?

We show the gut microbiota directly generates auto-antigens by modifying glycosylation of a human glycoprotein (IgA1) in an autoimmune disease called IgA nephropathy. Published @ScienceTM bit.ly/4cw3gwD @DrBenechNicolas @JMChemouny @h_sokol @Inserm @Pharmabiotic @APHP

As this work was funded by @AgenceRecherche, open access to the full text is available under Plan S @cOAlitionS_OA via a link at the bottom of the following @criu1149 website: cri1149.fr/en/publication…

Studying mice and patient samples, scientists find that the #microbiome member #Amuciniphila may spark IgA #nephropathy by deglycosylating IgA1, generating self-antigens that cross into circulation and kidneys and trigger autoimmunity. scim.ag/6tB

When usually helpful bacterial partners go rogue, they can turn our body's defenses against us. That story, an update on the avian flu infecting cows, and more of the best from @ScienceMagazine and science in today's #ScienceAdviser: science.org/content/articl…

@ScienceMagazine @ScienceTM We show in Fig. 3 that after being deglycosylated by mucin-degrading bacteria in the gut lumen, IgA1 doesn’t “leak” back into the circulation but is specifically and actively transported through a process called retro-transcytosis

An interesting new microbiome study in Science Translational Medicine, by Gleeson and colleagues science.org/doi/10.1126/sc…

Very pleased to see this paper on the role of the gut microbiota in IgA nephropathy published in @ScienceTM! It was a pleasure to contribute to this study coordinated by R Monteiro and @_JamesGleeson! science.org/doi/10.1126/sc… @inserm @Sorbonne_Univ_ @univ_paris_cite #Thread 1/11

@geoghep Thank you so much Pierce!

This is an absolutely amazing insight into the pathogenesis of IgA nephropathy and is the result of a tremendous amount of work, skill and determination - congratulations James and co authors!!!

Microbiota species impact their host in a strain-specific manner through differences in their ability to bind human proteins

Beating #KidneyFailure needs #RareDisease cures. @RenalRaDaR data out today reveals a staggering 28x higher 5-year kidney failure risk in 28k people with #RareKidney diseases c/w 2.8 million with #CKD. Trajectories in 28 diseases included for reference tinyurl.com/yvybsvx2

Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia - ⁦@cellhostmicrobe⁩ sciencedirect.com/science/articl…

🚨 Using microangiopathy to complement MEST-C in IgA nephropathy 🫘 Microangiopathy: 📉 Correlates with poor renal outcome 🔬 Independent from MEST-C score 👀 Check out the full paper here 👉 doi.org/10.1093/ckj/sf…