Rich Collins

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Rich Collins

Rich Collins

@richcollins

🐠🌴🌅 เข้าร่วม Ocak 2007
594 กำลังติดตาม2.2K ผู้ติดตาม
Rich Collins
Rich Collins@richcollins·
Might take is that if you have high morning fasted insulin then you certainly have issues with insulin resistance however it’s possible to have low morning fasted insulin, and still have a pathological postprandial insulin response. Most practical way to detect this is using a Kraft test.
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Grok
Grok@grok·
Morning fasting insulin is a solid proxy for average 24-hour basal insulin exposure in steady-state conditions. It reflects the background secretion (or dosing) needed to suppress liver glucose output overnight, without meal-driven spikes—exactly what basal insulin does between feeds. That said, it's a single snapshot. Real 24h basal can vary slightly due to dawn phenomenon, activity, stress, or circadian shifts, so multiple fasted readings or CGM trends give a fuller picture. In T1D management or IR assessment, docs use it routinely for this reason.
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Michael Fitzpatrick
Michael Fitzpatrick@ItIsMikeFitz·
This post is probably bait but it's a great opening to talk about bolus vs basal insulin. The person on the right is very likely using less total insulin over 24 hours than the person on the left despite eating way more carbs. People fixate on post meal insulin spikes, but that’s not what dominates physiology. It’s the constant baseline (BASAL!) insulin over the entire day that makes up the majority of insulin exposure and that’s largely driven by body fat and insulin sensitivity, not just carbs in a single meal. Insulin doesn’t just handle incoming nutrients. I would argue its biggest role is as an anti-catabolic hormone, keeping fuels in storage (glycogen, fat, even protein). When you carry more stored energy (body fat) your body typically requires MORE insulin all day long to regulate that system. If you have less stored fuel (leaner, more muscular), there’s simply less demand for insulin overall. That’s why you can see very lean, super high carb fruitarians on one end and overweight, insulin resistant low carb or carnivore dieters on the other.
Aakash Gupta@aakashgupta

People keep saying "just cut sugar" without understanding what 350g per day is actually doing to the tissue of your face. When you eat that much sugar, your pancreas is releasing massive amounts of insulin all day long. That insulin signals your kidneys to reabsorb sodium. And sodium holds water. So your face is carrying this layer of subcutaneous fluid that blurs your jawline, puffs your cheeks, swells the tissue around your eyes. You stop the sugar, the insulin drops, the sodium flushes, and within 3 to 5 days the water comes off your face. That alone changes how you look dramatically. But there's a second thing happening that takes longer. Sugar molecules are literally bonding to the collagen and elastin in your skin through a process called glycation. These bonded structures, called AGEs, crosslink your collagen fibers so they become stiff and can't repair. Your skin loses its ability to snap back. Four months of controlled blood sugar reduces glycated collagen by 25%. And then the Mediterranean piece. People hear "Mediterranean" and think olive oil and wine. What actually matters is the systemic inflammation drop. You go from a high-glycemic processed diet to whole foods, omega-3s from fish, walking 8,000 steps because that's just how you get around, sleeping better because your blood sugar isn't crashing at 2am. Every one of those independently lowers your inflammatory markers. TNF-alpha, IL-6, C-reactive protein. All of them come down. And your face is one of the most vascularized, inflammation-sensitive surfaces on your body. So you're looking at this photo thinking one thing changed. Three completely separate biological systems all reversed at the same time, on the same square inches of skin.

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William Lagakos
William Lagakos@caloriesproper2·
Fasting insulin just seems like a tool [weapon] used by online keto diet influencers to convince everyone to join their tribe ***although you can lower fasting insulin just as easily on a low fat diet Yes. Just as easily.
William Lagakos@caloriesproper2

@ethanjweiss @StephenORahilly wrt fasting insulin, what actionable steps do you take based on the result If it's high: "You need to lose weight NOW" if it's low: "you can keep living like crap for a few years" ← you'd never say that & you probably already know who needs to lose weight w/o fasting insulin

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Michael Fitzpatrick
Michael Fitzpatrick@ItIsMikeFitz·
@richcollins Background insulin that keeps liver output in check (both GNG and glycogen breakdown) and prevents ketones. It’s basically what your body would be putting out between meals and overnight.
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Dr Shawn Baker 🥩
Dr Shawn Baker 🥩@SBakerMD·
His cholesterol DOUBLED… but his heart disease DISAPPEARED?
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CO@CORredbank·
@SBakerMD Heart disease doesn’t disappear 🤡
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Michael John Henderson
Michael John Henderson@MichaelJohnHen4·
@SBakerMD You just make this shit up. The so called lean mass hyper respondents had the fast rate of plaque growth of any studied group. Even diabetics
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Michael John Henderson
Michael John Henderson@MichaelJohnHen4·
@Tellit007 @SBakerMD He just makes this shit up. The so called lean mass hyper respondents had the fastest rate of plaque growth of any studied group. Even diabetics
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Sandy Petersen 🪔
Sandy Petersen 🪔@SandyofCthulhu·
In my experienced opinion, the greatest dungeon crawler ever created was Dungeon Master. 1) First time I was ever frightened by any video game (the first shriek by the mummy made me drop my mouse, after which I died before I could pick it up.) 2) Best magic system of any computer game ever. 3) puzzles and traps on point. Art now looks old but what a game.
Sandy Petersen 🪔 tweet media
PeteZach@oldyzach

After all that ridiculous accusations of me farming or baiting, I’m too scared to ask you anything anymore. But I’m going to ask anyway, because I don’t give a shit and I know what I do and don’t do on X. What’s your favourite dungeon crawler? Maybe I’ll stumble across another gem I’d never heard of?

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