
@DrWilliamMakis Hypothesis worth testing: Alcoholism may stem from inherited mitochondrial dysfunction (maternally passed) → gut energy deficit → broken gut-brain signaling via the vagus nerve → dysregulated reward baseline → alcohol as unconscious self-medication.
If mebendazole/fenbendazole/ivermectin modulate mitochondrial substrate-level phosphorylation as Seyfried suggests, could they correct the ROOT cause of alcohol dependence rather than chasing dopamine symptoms?
Children of alcoholics inherit this mitochondrial profile before ever touching alcohol. Fix the gut mitochondria, fix the signal, remove the craving?
Would you consider testing this?
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