Tristan Farmer

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Tristan Farmer

Tristan Farmer

@001TMF

AI for programmable biologics & protein design | Building biological intelligence | Longevity & personalised therapies | GitHub: 001TMF | UoE

Sumali Şubat 2026
67 Sinusundan266 Mga Tagasunod
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Tristan Farmer
Tristan Farmer@001TMF·
Betting beyond generative models in bio. A weekend is all it took for our biological intelligence platform to go from data —> viable antibodies. Fully closed loop design and fully autonomous. I didn’t touch a thing.
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Bryan Johnson@bryan_johnson

If Hantavirus mutated into a global threat, it would unleash AI + biotech unlike anything we've ever seen. > genome sequenced and public in 4 hours > AlphaFold maps every protein target > AI screens 10,000 drugs in 24 hrs > 50 vaccine candidates designed simultaneously > AI designed antibodies in days > risk of death computed instantly > decentralized trials launch globally > enroll from home > 20 countries manufacturing at once > first doses in three weeks > real-time dose characterization > your genome + biomarkers determine your protocol > variant map updates every hour No one would wait for governments.

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Tristan Farmer
Tristan Farmer@001TMF·
Agentic Bio will change how drugs are discovered. I’m not talking about orchestration. Reasoning has increased our success rate significantly.
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Malika 🧬
Malika 🧬@malikules·
"we lack the biological data to train our models. therefore, we must extract it, by force, from every entity that has it. and once we have bled them dry, we will crush them into the dirt, leaving nothing but the pristine, suffocating illusion of our own benevolence"
Andrew Curran@AndrewCurran_

Sam Altman, Dario Amodei, Demis Hassabis and many others have signed a letter urging Congress to increase security on orders of synthetic nucleic acids - and the equipment needed to make them - as models continue to become increasingly bio-capable.

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1752vc
1752vc@1752vc·
30+ investors you can talk to today 👇 VCs @lucasjpols - @1752vc @Trace_Cohen - Six Point Ventures Claire Cherry - Era VC Tobias Bauer - TBVentures @DrewBailer - Fiat Ventures Ohad Tzur - Venture Forward Adam Bo - A12i Nikhil Choudhary - Nirman Ventures Sébastien Gros - Headline & Will Bruno Villetelle - VU Ventures Olivia O'Sullivan - Forum VC James Roycroft-Davis - Evio Colin Gardiner - Yonder Ethan Austin - Outside VC Leon Eisen, PhD - Network VC Pablo Srugo - Mistral @BrandonHoffman_ - @SunsetVC Dylan Kaplan - Alumni VC Etienne Boutan - Intuition VC Kenneth Kashif Thomas - BackFuture VC Sam Merullo - UpsideDown VC Ankur Sethi - Winner Capital Shane Ray Martin - B Ventures Chris Tottman - Notion Capital David Y. - Ethos Fund Jahn Karsybaev - Big Sky @ItsElanaGold - Two Roads Angels @mdantus @xlehmann @gambino @joningib
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Tristan Farmer nag-retweet
Matthew F. McKnight
Matthew F. McKnight@matt_f_mcknight·
Andrew, I signed, this is important work - but we need to be really careful to not get distracted from the bigger problem of rapidly decentralizing capabilities to create / deploy biothreats. Detection, identification, response - globally and persistent/pervasive - should be the top priority. DNA synth will be distributed, it won’t be centralized in a way that can be effective with this approach. Desktop, at home, new synthesis tech coming, etc. Not to mention we can’t regulate China, etc. and this is a globally distributed technology. This kind of legislation is sort of like telling people not to write viruses on all their home computers or, worse, if they do we will monitor them all to see what they type (which people would get around of course). Important now, not practical in medium/long run. Necessary to reduce some risk, not nearly sufficient… nor where our top priorities should be. Only practical thing is to make detection and response work great, global, and fast. e.g. - The "finger in the dike" refers to the classic legend of the "Little Dutch Boy" who selflessly plugs a small leak in a dam with his finger, holding back the sea to save his town from a devastating flood. Small, temporary stopgap to a major, escalating problem.
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Tristan Farmer
Tristan Farmer@001TMF·
@ebetica Kinda want to try to see if our biological reasoning approach could boost the success rate.
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Zeming Lin
Zeming Lin@ebetica·
This protocol was validated in our paper with minibinders and scfvs against 5 hard therapeutically relevant targets. We validated this protocol with BLI, live cell immunofluorescence, functional assays, and cryoem structures. It's not about how many binders you can design, it's about whether they'll work in the lab.
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Zeming Lin
Zeming Lin@ebetica·
How to design your own PD-1 binder in 4 easy steps: 1. Download the tutorial notebook from the ESM team 2. Get a @modal API key to scale it up 3. Scaling it up, O($1000) will get you a 96 well plate of minibinders with >50% success rates on typical targets 4. Test it in the lab!
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Tristan Farmer
Tristan Farmer@001TMF·
All the people doing protein interaction predictions. With the release of openBind, why not train a model on that, then fine-tune it on PPI?
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Tristan Farmer
Tristan Farmer@001TMF·
Rebranding the term employee to agent. Now we are 100% agentic.
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Tristan Farmer
Tristan Farmer@001TMF·
@boazbaraktcs Bit pointless. First, no pledge to actually support nucleotide producers just passes on the burden. Second, this technology is so widely available that it likely slows the good actors more than it slows the bad ones.
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Boaz Barak
Boaz Barak@boazbaraktcs·
Proud to have co-signed this letter. Bio capabilities of AI systems, including foreign and open source ones, are fast advancing. We can't assume that bad actors will not have access to such capabilities and need to ensure information is not the only bottleneck.
Alec Stapp@AlecStapp

No one should be able to order a bioweapon through the mail. @IFP & @JoinFAI are proud to co-lead an open letter calling for mandatory DNA synthesis screening & recordkeeping. Signatories include: - Sam Altman, CEO & Co-Founder, OpenAI - Dario Amodei, CEO & Co-Founder, Anthropic - David Baker, Director, Institute for Protein Design; 2024 Nobel Prize in Chemistry recipient - Patrick Collison, CEO & Co-Founder, Stripe - Paul Graham, Founder, Y Combinator - Demis Hassabis, CEO, Google DeepMind; 2024 Nobel Prize in Chemistry recipient - Emily Leproust, CEO & Co-Founder, Twist Bioscience - Lawrence Lessig, Roy L. Furman Professor of Law and Leadership, Harvard Law School - Gerald W. Parker, former Special Assistant to the President for Biosecurity and Pandemic Response - Mustafa Suleyman, CEO, Microsoft AI - Alex Tabarrok, Professor of Economics, George Mason University - Alexandr Wang, Chief AI Officer, Meta; Founder, Scale AI - Christine E. Wormuth, President & CEO, Nuclear Threat Initiative; 25th Secretary of the Army Read the letter and see the full list of signatories: screendna.org Many DNA synthesis companies voluntarily screen orders to mitigate biosecurity risks, but no law requires them to do so. Leaders in AI, biotech, life sciences, national security, and the nucleic acid synthesis industry agree that Congress should act to strengthen safeguards against biological threats. @deanwball put it well in the WSJ: “If you’re synthesizing the stuff that yields biological life and viruses, we’re asking you to screen to see whether it is dangerous in some way. That seems like a reasonable thing for society to insist upon.”

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Tancrede
Tancrede@Tancrededib·
if you're looking for a cofounder, present yourself in one sentence + space you want to work in everyone else, like the profiles that stand out i'll be looking to invest in the best ones
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Jake Adler
Jake Adler@jakeadler·
When people visit Pilgrim they are noticeably shocked by how simple it has been for us to obtain biological agents. This is a major step in the right direction
Alec Stapp@AlecStapp

No one should be able to order a bioweapon through the mail. @IFP & @JoinFAI are proud to co-lead an open letter calling for mandatory DNA synthesis screening & recordkeeping. Signatories include: - Sam Altman, CEO & Co-Founder, OpenAI - Dario Amodei, CEO & Co-Founder, Anthropic - David Baker, Director, Institute for Protein Design; 2024 Nobel Prize in Chemistry recipient - Patrick Collison, CEO & Co-Founder, Stripe - Paul Graham, Founder, Y Combinator - Demis Hassabis, CEO, Google DeepMind; 2024 Nobel Prize in Chemistry recipient - Emily Leproust, CEO & Co-Founder, Twist Bioscience - Lawrence Lessig, Roy L. Furman Professor of Law and Leadership, Harvard Law School - Gerald W. Parker, former Special Assistant to the President for Biosecurity and Pandemic Response - Mustafa Suleyman, CEO, Microsoft AI - Alex Tabarrok, Professor of Economics, George Mason University - Alexandr Wang, Chief AI Officer, Meta; Founder, Scale AI - Christine E. Wormuth, President & CEO, Nuclear Threat Initiative; 25th Secretary of the Army Read the letter and see the full list of signatories: screendna.org Many DNA synthesis companies voluntarily screen orders to mitigate biosecurity risks, but no law requires them to do so. Leaders in AI, biotech, life sciences, national security, and the nucleic acid synthesis industry agree that Congress should act to strengthen safeguards against biological threats. @deanwball put it well in the WSJ: “If you’re synthesizing the stuff that yields biological life and viruses, we’re asking you to screen to see whether it is dangerous in some way. That seems like a reasonable thing for society to insist upon.”

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Tristan Farmer
Tristan Farmer@001TMF·
Guess now is the time to say we work in biodefense.
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Tristan Farmer
Tristan Farmer@001TMF·
@navyadotbio Bloating US nucleotide producers will not be the saving grace. These tools are already out in the open. Genies out.
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navya b.
navya b.@navyadotbio·
@001TMF pretty much, especially considering the first 2 are actively profiteering off conventional weapons deployment
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Tristan Farmer
Tristan Farmer@001TMF·
Right gang, we made these tools your problem now.
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Tristan Farmer
Tristan Farmer@001TMF·
Seems like a bit of a consensus from bio-linked people. x.com/001TMF/status/…
Ankit Gupta@agupta

I mean this is great and all, but….how do you actually do this? Beyond some very well known cases, to what extent can we even take a strand of DNA and say “this is a threat”? I suppose the specific threat is someone makes a crispr guide and edits something that makes a thing more pathogenic? But…how would we know that? not to mention that this technology is so widely available it likely slows the good actors more than it slows the bad ones.

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