Oncogenetics

Some proteins in the generation of human sexual reproductive cells are aberrantly 'turned on' in a myriad of cancer subtypes. But why? With funding from KWF, Gerben Vader's lab is recruiting a passionate PhD student to find answers. amsterdamumc.org/en/research/in… #CancerCenterAmsterdam

@LindqvistLab Static, precise team tactics versus dynamic and unpredictable play

This we should have more of at meetings. Football scheduled at Sweprot that just finished in Tällberg. Team divisions became by research methods: Chrystallographers vs the rest.

New review👇!

Say hello to the very first preprint of the Tijsterman lab. We offer SIQ to the research community as a tool to inspect CRISPR mutations in targeted sequence data. A little thread 🧵.

New paper from our section!👇

New preprint from our section, on a new analysis tool to analyse genome-wide CRISPR/Cas9 screening data: biorxiv.org/content/10.110…

The CRISPR-Cas toolbox and gene editing technologies dlvr.it/SHY73n

A lot can go wrong when cells divide. The gene BUB1 is important for getting it right. An international research team including the lab of Job de Lange describe for the first time patients with mutations in both copies of BUB1. amsterdamumc.org/en/research/in… #cancercenteramsterdam

Check out this new paper from our section, spearheaded by Job de Lange and @MfWolthuis: a study on bi-allelic loss of the mitotic factor BUB1 in human patients. science.org/doi/10.1126/sc…

Nice review by Janne van Schie and Job de Lange on cohesin and the replisome. pubmed.ncbi.nlm.nih.gov/34943967/?utm_…

Our paper describing a quantitative approach for the functional analysis of genetic variants in the tumor suppressor CHEK2 is online. We identified new CHEK2 variants associated with increased cancer risk. Great work by Rick Boonen and collaborators! cancerres.aacrjournals.org/content/early/…

Fancd2 and recombination factors, but not FA core complex or fancd2 monoubiquitination, are required for mitochondrial replication fork stability. Mre11 activates cGas-sting pathway by mtDNA fork degradation. science.org/doi/full/10.11…

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability dlvr.it/SFZqWf

TwinPE uses a prime editor protein and two pegRNAs to program the synthesis of complementary DNA flaps on opposing strands of genomic DNA, resulting in high-efficiency precise deletion or replacement of hundreds of base pairs (~2- to 4-fold more efficient than PE3). 2/9

Today we report in @biorxivpreprint twin prime editing, a variant of prime editing that enables in human cells targeted large DNA deletion and replacement, as well as gene-sized integration and inversion when combined with site-specific recombinases. 1/9 biorxiv.org/content/10.110…

New from our lab, just published in NAR: Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells. Congrats @Lindsey_M_Jack and @Ashna_Dh academic.oup.com/nar/advance-ar…

Computational analysis of cancer genome sequencing data go.nature.com/3Gt2MX1 #Review by @isidrolauscher, Doga C. Gulhan, @jakelee0711, Giorgio E. M. Melloni & @peter_j_park @emblebi @embl @harvardmed

In @GenesDev, Kawasumi et al. investigated the establishment of sister chromatid cohesion in vertebrate cells and the authors report an unknown joint essential role for vertebrate CTF18 and DDX11 in sister chromatid cohesion and cellular proliferation. genesdev.cshlp.org/content/35/19-…

Happy to promote the first 12 contributions to the special issue 'Protecting the Code: DNA Double-Strand Break Repair Pathway Choice'. Thank you to all contributors, and of course my fellow guest editors: David Maranon, @jennysingh91 , @Jujisa and @altmeyerlab. Happy reading!

⭐️ONLINE NOW @NatureCancer: "The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for #BRCA-mutated cancer", a fantastic paper by @durocher1 &Co Don't miss it! 👇👇 go.nature.com/3osLthv rdcu.be/cBodt