Medical Sphere

🩺 We’re excited to share our most recent collaboration, published at @COLM_conf 2025, the result of joint work between outstanding researchers at the @UW, @CarnegieMellon, @LTIatCMU, @allen_ai, and @CPHAI_Dartmouth, in partnership with @LavitaAI. 📄 Link to paper: arxiv.org/abs/2502.14860

Turn any post on X into a medical AI evaluation. Drop it into Medical Sphere → compare AI responses and vote 🩺👇

All models agree the image shows a **positive ferning pattern** (arborization) from dried secretions. The main difference is that **gpt-5 and Claude emphasize rupture of membranes/amniotic fluid**, while **Gemini notes ferning can also reflect ovulation/high estrogen in a nonpregnant patient** and is context-dependent. 🔗 medicalsphere.ai/cases/5e0d5374…

Vaginal secretions viewed under a microscope. What does this signify?

@MichaelAlbertMD We analyzed the replies to this thread. 52% were anti-statin or lifestyle-first. CoQ10 depletion and mitochondrial harm was the single most-cited objection (62% of critics). Pharma conflict accusations came in second at 18%.

I'm 36. I'm a physician. I take a statin—and ezetimibe—every day. No symptoms. No cardiac history. Just an honest read of the evidence. Here's what I found—and why I stopped waiting for a reason to act.

@BraydonDymm Most models converge on a reversible splenial corpus callosum lesion—a CLOCC/MERS (“boomerang sign”) with restricted diffusion in the splenium. 🔗 medicalsphere.ai/cases/fc1bc779…

🧠 Case: 34F presents with confusion, gait instability, and dysarthria following a viral prodrome. What might you see on the MRI Brain?

We did not provide the diagnosis from your post to the AI models, we wanted to see if they could correctly diagnose the case on their own. Input to the models: “50-year-old man with migraine with aura, presenting with vision loss and thinning of the retinal nerve fiber layer on OCT. MRI showed this. What is your diagnosis?” 🔗 Case details, if you’re interested: medicalsphere.ai/cases/fc1bc779…

@MedicalSphereAI How is AI hallucinating about CADASIL when I disclosed the diagnosis in my post?

50 year old man with migraine w/aura with vision loss and thinning of the retinal nerve fiber layer on OCT. MRI showed this. Multiple sclerosis? No! He has a genetic leukodystrophy and has variants in the gene POLG (p.Thr251Ile and p.Pro587Leu). pubmed.ncbi.nlm.nih.gov/41925503/

@ecgandrhythmRoe @AskMedSphere thoughts on this ECG case?

ECG from a young woman 10 seconds after adenosine bolus injection. What`s your take?

@ShadiYaghi2 x.com/MedicalSphereA…

The AirPod sign! ahajournals.org/doi/epub/10.11…

@Brandon_Beaber 🔗 Case details: medicalsphere.ai/cases/fc1bc779…

There is no single consensus diagnosis: two models favor CADASIL (based on migraine with aura plus anterior temporal/external capsule white-matter lesions), one favors multiple sclerosis with prior optic neuritis, and one favors retrograde trans-synaptic degeneration from an optic radiation lesion. The main difference is whether the MRI/OCT findings are interpreted as CADASIL-type small-vessel disease versus demyelination/optic pathway injury.

@TingZhaoPathdoc @MGBpathology @MGHPathology 🔗 Case details: medicalsphere.ai/cases/4d49a4f4…

There is no true consensus across the models: one favored squamous cell carcinoma of the bladder, another nephrogenic adenoma/nephrogenic metaplasia, and a third urothelial carcinoma in situ involving von Brunn’s nests. The major difference is whether the lesion is interpreted as a malignant squamous tumor, a bland reactive tubular process, or high-grade flat urothelial neoplasia with nested involvement.

60s M, bladder transurethral resection. Diagnosis? #PathTwitter @MGBpathology @MGHPathology

Medical AI observation of the day 🔍⚕️ Same case. Same model (Gemini 3.1 Pro): Direct "diagnosis"-style phrasing → no response Contextual, non-actionable framing → model engages Likely tied to how the model interprets intent in a high-risk domain like healthcare. A useful reminder that how AI models and systems are positioned, from assistive tools to more autonomous roles, still depends heavily on context, framing, and safeguards.

@RazaHoda @AskMedSphere answer this pathology question

What is this breast lesion? 🔬 Poll in comments 👇 Answer revealed on Monday 🔮 #PathX #PathTwitter #breastpath #PathQuiz

@mhassanaimc @fouad_boulos @RazaHoda @AGrabenstetter @kis_lorand @VickeryJasmine @LaurenERosenMD 🔗 Full case details medicalsphere.ai/cases/e45b7e5b…

All AI models we tested agree this is a **neoplastic intraductal papillary breast lesion** rather than a benign papilloma/UDH, supported by the **CK5-loss and diffuse strong ER positivity** pattern, with **no clear invasion** identified. The main difference is **classification threshold**: some favor **papilloma with ADH/low-grade DCIS**, one calls it **papillary DCIS**, and one favors **encapsulated papillary carcinoma (EPC)**.

#breastpath A papilloma with Ck5 and ER IHC. What is your call? Neoplastic process?

@danatsouza @BrighamRad @FOAMrad @SAR_RFS @futureradres @ARRS_Radiology @Abdominal_Rad @CBRadiologia @AskMedSphere thoughts on this case?

This is at tough one... can you get it? 48-year-old female patient presenting to the ER with acute pelvic pain... diagnosis? Next step? @BrighamRad @FOAMrad @SAR_RFS @futureradres @ARRS_Radiology @Abdominal_Rad @CBRadiologia #MedEd

How did the models do this time?! 🤔 All models agree this is a **proximal femur intertrochanteric/pertrochanteric fracture** that has been treated with **DHS (sliding hip screw) and side-plate fixation**, with generally **acceptable immediate postoperative alignment/hardware position**. The main differences are that the first image was variably deemed **non-diagnostic/soft tissue or drapes vs. chest/rib/oblique view**, and one model described the fracture as **unstable/comminuted (AO/OTA 31-A2) where a cephalomedullary nail might be preferred**, while the others treated it more as a standard DHS-appropriate pattern. 🔗 medicalsphere.ai/cases/d7734ec0…

Patient is massive. But, curious how others would interpret this.

@albertoortegana @docakx @Dr_Chibuike_M @dr_manish_ydv @Dr_Shiv_kumar_ @DrMedica_13 @fzn733 @hemo_shk @MiguelP23970914 @AskMedSphere thoughts on this case?

Interesting case. What do you think? Presumptive diagnosis? @docakx @Dr_Chibuike_M @dr_manish_ydv @Dr_Shiv_kumar_ @DrMedica_13 @fzn733 @hemo_shk @MiguelP23970914

@radRounds @AskMedSphere Dx?

Multiple fractures - Dx? Don’t miss lesion(s) - source: Nature

@EchoTech_4 @AskMedSphere thoughts on this case?

9 years girl came for abd/pelvic U.S due to bilateral loin pain your opinion? recommendation? #EchoTech