andrewkitchell

How many softwares are required to run a #STR/#VR business? 1? 3? 5? We'd argue the number could be 20+, and put this market map together to share why. 🗺 Figma Map: lnkd.in/gn4vbRXT 📃 Category Write-Up: lnkd.in/gUH5RD9Q [ Backstory/links below ]

@rohindhar Cole Valley at 10?? Mission Dolo / Castro grouped AND at 16...?! Will have to debate this over a hang w/ @YieldOnCostSTR soon...

Rohin’s Rankings of the Top 20 Best Neighborhoods in San Francisco (totally non-scientific but totally right, probably) 1. Noe Valley 2. Presidio Heights 3. Alamo Square / NOPA 4. Lake District & Seacliff 5. Inner Sunset 6. Inner Richmond 7. Ashbury Heights / Corona Heights 8. Pac Heights 9. Marina / Cow Hollow 10. Cole Valley 11. Jordan Park / Laurel Heights 12. Central Richmond 13. Outer Sunset 14. Rincon Hill / East Cut 15. Central Sunset 16. Castro / Mission Dolores / Eureka Valley 17. Glen Park 18. Duboce 19. Bernal Heights 20. Russian Hill Other neighborhoods not mentioned didn't make the cut Agree or no?

It’s Tester Time🤙

🎥 Missed our Revenue Manager Roundtable on high season insights? Replay now to learn if you can still leverage average booking windows in your pricing strategy 👀 🏖️🏔️ hubs.ly/Q02QDrXD0 #VacationRentals #RevenueManagement #STR

@rafat @skift Congrats on an excellent event! Great speakers, amazing attendees, beautiful venue, and that food…!

This @skift team, now closing on 100, just pulled off what I would bet is amongst the best business conferences anywhere, three days of absolute magic at Skift Global Forum in NYC. So proud of our team and what we enable in the world of travel.

🚀 It's Launch Day 🚀 Meet Dynamic Sets – to help you capture the unique value of your business for better: ➡️ Benchmarking ➡️ Pricing Strategy Decisions ➡️ Owner Reporting & Retention ➡️ Owner Acquisition ➡️ Merchandising youtube.com/watch?v=mravyU…

Ready for another sneak peek at what we’re launching next week? Time to put your performance in context. Carry it everywhere to inform every decision. Let's drive every aspect of your portfolio's revenue and growth strategy. Until next week 🚀 #wheelhouse #productlaunch

Introducing Eureka, the world’s first AI doctor. Eureka can order labs and give care in the real world. It is covered by health insurance just like a healthcare provider and is already working with thyroid patients in the US. It’s 90x faster than most care in the US, and 9 out of 10 users want to continue with Eureka’s recommendations. Eureka thinks like a doctor and reasons like a detective. Before any care starts, a board-certified physician reviews Eureka’s recommendations to make sure everything is in order. Eureka currently specializes in endocrine conditions like thyroid and diabetes. Here’s what users think about Eureka 🧵 (1/5)

@patrickc @arcinstitute Wow. On so many levels.

This morning, Nature published two papers on bridge editing, the new genome engineering technology from @ArcInstitute: nature.com/articles/s4158…, nature.com/articles/s4158…. I'm quite excited about its potential! Since the whole thing is pretty arcane, I fed the blog post (arcinstitute.org/news/blog/brid…) to Claude 3.5, and asked it to write an introduction. Below is the rather impressive (unedited) result. Genome Design: The Bridge to Our Biological Future I. Imagine you're trying to edit a document, but instead of a cursor, you have a pair of scissors. You can cut out words you don't like, maybe paste in a few new ones, but precise editing? Forget about it. Now imagine someone hands you a pen. Suddenly, you can write whatever you want, wherever you want. This is the kind of leap we're seeing in the world of genome editing. For the past few decades, we've been snipping away at genomes with tools like CRISPR, making impressive progress but always constrained by the fundamental nature of our tools: they cut DNA. But what if we could write directly into the genome, inserting whatever we want, wherever we want, without ever making a single cut? This isn't just a "wouldn't it be nice" daydream anymore. Researchers at the Arc Institute have discovered a new system that does exactly that. They're calling it "bridge recombination," and it might just be the biggest revolution in genetic engineering since CRISPR. II. To understand why this is such a big deal, we need to take a quick tour through the history of genetic manipulation. In the late 1990s, we discovered RNA interference (RNAi). This was our first real taste of programmable biology. We could use short RNA sequences to target and shut down specific genes. It was like having a universal remote control for gene expression. Cool, right? Then came CRISPR in the early 2010s. Suddenly, we could not just turn genes off, but edit them directly. It was like upgrading from a remote control to a basic text editor. We could cut out bad genes and paste in good ones. But there was always a catch: CRISPR works by cutting DNA, and cells don't always repair those cuts exactly the way we want them to. Both of these systems were revolutionary, but they shared a common limitation: they were destructive. They worked by breaking things – either the RNA transcripts of genes (in the case of RNAi) or the DNA itself (in the case of CRISPR). III. Enter the bridge recombination system. The researchers at Arc Institute, led by Dr. Patrick Hsu, were poking around in the genomes of bacteria, looking at transposable elements. These are sometimes called "jumping genes" because they can cut themselves out of one part of a genome and paste themselves into another. They were particularly interested in a group called IS110 elements. These are about as minimalist as you can get while still being functional – just a gene for the enzyme that does the cutting and pasting, plus some mysterious flanking DNA segments. What they found was surprising. When an IS110 element cuts itself out of a genome, those mysterious flanking segments join up to form an RNA molecule. This RNA folds into two loops, one that binds to the IS110 element itself, and another that binds to the target DNA where the element will insert itself. This RNA – which they've dubbed "bridge RNA" – is the key to the whole system. It's like a set of instructions, telling the enzyme exactly where to insert the DNA and what DNA to insert. IV. Now, you might be thinking, "Okay, that's neat, but how is this different from CRISPR?" The key is in how the insertion happens. CRISPR works by making a cut in the DNA and then relying on the cell's repair mechanisms to insert the new DNA. It's effective, but it's also a bit like performing surgery with a chainsaw. Sometimes you get exactly what you want, but often you end up with small errors or unwanted insertions or deletions. The bridge recombination system, on the other hand, doesn't cut the DNA at all. It unzips a small section, inserts the new DNA, and zips it back up again. No broken DNA strands, no relying on error-prone repair mechanisms. It's precise in a way that CRISPR can only dream of. But the real magic is in the programmability. Remember those two loops in the bridge RNA? They can be programmed to recognize any DNA sequence. This means you can tell the system to insert any piece of DNA into any location in the genome. It's like having a word processor for DNA. V. The implications of this are staggering. Here are just a few possibilities: • Gene Therapy 2.0: Current gene therapy approaches often rely on somewhat random insertion of therapeutic genes. With bridge recombination, we could insert corrective genes exactly where they need to go, without risking disruption of other important genes. • Synthetic Biology: Want to give an organism a completely new capability? Just design the gene and insert it precisely where you want it. • Evolutionary Biology: We could insert reporter genes at specific locations across the genome, allowing us to watch evolution happen in real time. • Agricultural Improvements: We could insert beneficial genes into crops with unprecedented precision, potentially revolutionizing our ability to create drought-resistant or nutrient-enhanced plants. • Bioengineering: Imagine being able to design and build entire genetic circuits, inserting each component exactly where it needs to be for optimal function. VI. In the grand scheme of things, the discovery of bridge recombination feels like a pivotal moment. It's as if we've been trying to write the book of life with a typewriter, and someone just handed us a word processor. The researchers at Arc Institute have opened a door to a new era of genome design. As with any breakthrough of this magnitude, it's hard to predict exactly where it will lead. But one thing is certain: the future of biology just got a lot more interesting. As we stand on the brink of this new frontier, I'm reminded of a quote from Arthur C. Clarke: "Any sufficiently advanced technology is indistinguishable from magic." With bridge recombination, we're not just editing the genome anymore. We're writing it. And that, my friends, is pretty close to magic.

@uniquestaysguy Perhaps TikTok, depending on regulations. But yes, any marketplace/network could eventually be a great distribution point for listings. Someone just needs to build some tech to make it easier :)

Hot Take: Instagram will become the go-to booking engine for STRs and hotels by 2030. • Skip the 14% OTAs fees • Control the full guest interaction • Better booking experience for hosts and guests The direct booking movement is only getting started.

@KyleTibbitts @wander Been waiting for a San Juans spot. Nicely done!

Your ticket to the majestic beauty of the Pacific Northwest is here. Meet @Wander Orcas Island.

@YieldOnCostSTR Let me sponsor a bottle of wine for them?

Just realized a journalist with 100k+ followers is staying with us this weekend - what would you do for them?

California's vaccine equity policy distributed 40% of available COVID-19 vax to the least advantaged 1/4 of communities in CA. @Pres_Hoover_II of @CAPublicHealth + coauthors estimate 160,000 COVID-19 cases and hundreds of deaths were averted: bit.ly/3ypSSHi

@rafat @ravishndtv @ndtv Appreciate the recommendation. Wow. Powerful and thought-provoking film. Very impressed and inspired by @ravishndtv.

Possibly the most poignant journalism documentary ever made, the death of independent media in India, using @ravishndtv and what happened to @ndtv as a lens into it. Pay for it and watch it, you won't be sorry. jolt.film/watch/while-we…

@BoyanSlat @Greenpeace And, sorry you have to deal with this @BoyanSlat. Keep crushing!

@BoyanSlat @Greenpeace What a hilariously bad take @Greenpeace 😂

Really, @Greenpeace? greenpeace.org/africa/en/blog…

@nikitabier Mostly true, but have you ever seen a Senator or Congressman off camera? Every one I've seen present/work a room is insanely more gifted than they appear on TV.

@adambain Dream job.

We're hiring a junior investor to join us at 01A in either SF or NYC! We're looking for someone with previous investing experience who is excited about early growth businesses. Since we're a firm built by operators/for operators, previous operating experience is preferred. Apply here & shoot me a DM to give me the heads up you've done it: linkedin.com/jobs/view/3887…

@strMillenial @EmirDukic @useWheelhouse Built by you or a crew you know? :)

@strMillenial @EmirDukic @useWheelhouse Looks like a cool team! Consultant or technology? Site makes me think... consultant with maybe some good underwriting chops?

This is probably the most accurate STR tech landscape list that I've seen to date. Great work @andrewkitchell and @useWheelhouse team!

@rsgalloway @EmirDukic @useWheelhouse I was referring to STRs as a huge space, but they are also served by tons of providers & technologies.

@andrewkitchell @EmirDukic @useWheelhouse you mean STRs? or the market for tech serving STRs?