Pascal Devant

Ever wondered how inflammatory caspases recognize IL-1 cytokines for cleavage? Read more in our new paper, a collaboration between @jkagan1 and @WuLabHarvard labs out today @Nature See🧵👇 1/ @harvardmed @BostonChildrens @VirologyHarvard @HarvardMicro nature.com/articles/s4158…

New Lab Alert! I am thrilled to share that next month I am starting my new role as an Assistant Professor at The Wistar Institute. I am extremely excited to work with fantastic new colleagues at Wistar and collaborate with researchers across UPenn.

Excited to share an amazing video on the NLRP3 inflammasome pathway generated by talented Ann from the Iwasa lab @janetiwasa @Ann_HuiLiu. It shows the real cryo-EM structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. #cryoem @LeXiao17 Enjoy

Excited to share that my PhD work on ER mito contact sites is finally out at @MolecularCell! Big shout out to @stark2_d to take this across the finish line, and @YatrikShahLab and @LyssiotisLab for their guidance as always!

Tachykinin signaling defines distinct populations of glia in the enteric nervous system. Excellent work by Anu Muppirala, Meena Rao and team @BostonChildrens @harvardmed @PiN_Harvard published today in @NeuroCellPress cell.com/neuron/fulltex…

Together with Emma Dann, we are thrilled to present a massive new Perturb-seq atlas of 22M primary CD4+ T cells, from 4 donors, across 3 timepoints – the result of a decade-long collaboration between the Marson (@MarsonLab) and Pritchard (@jkpritch) labs. 🧵👇

We are excited to share our new @CellCellPress paper revealing mechanisms of action of promising drugs against the helicase–primase of herpes simplex virus 1 (HSV-1) 🤩@HarvardMicro cell.com/cell/fulltext/…

@biorxivpreprint Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells biorxiv.org/content/10.648… @HyuncheolJung @pascal_devant @Marsonlab @GladstoneInst @UCSF @jccarnevale

Another exciting paper from @GladstoneInst Genomic Immunology - check out our latest preprint on myeloid cell editing: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by @HyuncheolJung and @pascal_devant

Excited to share the first Co-First author manuscript from my postdoc in the Marson lab @GladstoneInst Great collaboration with @HyuncheolJung from @jccarnevale lab @UCSF on CRISPR editing and screening in primary human myeloid cells! See tweetorial below! biorxiv.org/content/10.648…

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells biorxiv.org/content/10.648… #biorxiv_immuno

New preprint from the lab from PhD student Seb Grant. Started as a summer side project and developed into an exciting story. Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling. biorxiv.org/content/10.110…

@dave_boucher Congrats on the cool findings!

Check out our latest work led by two talented postdocs, Madhura and Chris @TheBourneImmuno. We find that CASP4/5 can cleave and activate CASP3/7, acting as initiators of both pyroptosis and apoptosis. Notably, both are needed for full pathogen defense! biorxiv.org/content/10.110…

meta-PAMPs: A new class of immunostimulatory molecules that control the ability of bacterial factors to operate as PAMPs. Jordan Jastrab reveals that wall teichoic acid (WTA) is a key regulator of inflammasomes and interferons during infection. biorxiv.org/content/10.110…

#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 authors.elsevier.com/a/1leKGL7PXuFTj

New review from our lab. Kudos to PhD student @SebGrant346534. 10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry jbc.org/article/S0021-…

Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more. Kudos to Joon Choi for his exceptional work. @harvardmed @BostonChildrens royalsocietypublishing.org/doi/10.1098/rs…

In January 2026, I will be joining Berkeley @UCBerkeley as an Assistant Professor in the Department of Chemical and Biomolecular Engineering, College of Chemistry @UCB_Chemistry, with exciting connections with world-class communities including the Lawrence Berkeley National Laboratory @BerkeleyLab and the California Institute for Quantitative Biosciences @QB3Berkeley. Incredibly grateful to all the mentors (especially @ElowitzLab and @WuLabHarvard), colleagues, friends, and family who made this next chapter possible. ❤️🙏 Research directions and student/postdoc opportunities coming soon. Stay tuned! 👀

Chris's @TheBourneImmuno paper is online now. Huge thanks to @BookerMan_PSU for coordinating this special Juneteenth issue @ACSPublications ACS Bio & Med Chem Au. Congrats to our growing lab and all who contributed. Happy 4th everyone!! pubs.acs.org/doi/full/10.10…

Congrats to Gladstone Postdoc @pascal_devant who was named a 2025 Jane Coffin Childs Fellow! #JCCFellow bit.ly/4noZSZZ