David Meredith

71 posts

David Meredith

@NeuropathDM

Neuropathologist; Cancer genomics research; Assistant Professor, Harvard Medical School @BrighamWomens @BWHPath

Boston Beigetreten Ağustos 2012

126 Folgt316 Follower

David Meredith@NeuropathDM·22 Eyl

Thanks for including me in this great work!

Wenya Linda Bi@wenyalindabi

We’re excited to share our study looking at molecular classification and survival of 4,400 #gliomas @NeuroOnc A huge team effort over the years @MGBNeurosurgery @BWHNeurosurgery @DanaFarber, here’s what we found. 1/10 academic.oup.com/neuro-oncology…

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Kun-Hsing Yu@kunhsingyu·4 Eyl

Excited to share that our paper on a foundation AI model for cancer prognosis and pathology diagnosis is published in Nature today. nature.com/articles/s4158… @HarvardDBMI @NIH @NIGMS @CDMRP @AmericanCancer #AI #DigitalPathology

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My Neuropath News@NeuropathClinic·1 Eyl

cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas #neuropath academic.oup.com/neuro-oncology…

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David Meredith@NeuropathDM·8 Nis

@MAHoureih @DrJPLow EBV+ SMTs usually have an evident lymphocytic infiltrate and varying amounts of fascicular regions with blunted nuclei and primitive round cell areas. This tumor has a more uniform appearance with tapered “neural” nuclei to me. Any history of immunodeficiency?

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M Adib Houreih, M.D, DipRCPath محمد أديب حورية@MAHoureih·7 Nis

@DrJPLow SMA is very focal. Would this be acceptable in EBV associated smooth muscle tumors?

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M Adib Houreih, M.D, DipRCPath محمد أديب حورية@MAHoureih·5 Nis

1/2 #Neuropath For diagnostic help. Male. Adult. Extramedullary spinal mass. @CraigHorbinski @JaredAhrendsen @MalakAbed @astroade @padmapathology1 @NRiddleMD @vi_monappa @mlage @brainpathol @ijexpafo @MishiePishi @afgao @kelly_mrachek @NeuropathClinic @NeuropathDM @neuropath_uk

M Adib Houreih, M.D, DipRCPath محمد أديب حورية tweet media

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David Meredith@NeuropathDM·6 Nis

@MAHoureih @CraigHorbinski @JaredAhrendsen @astroade @padmapathology1 @NRiddleMD @vi_monappa @mlage @brainpathol @ijexpafo @MishiePishi @afgao @kelly_mrachek @NeuropathClinic @neuropath_uk @cherrycyho @drmbuckland @IntSocNeuropath @HopkinsNeuropth @DrGeeONE @DrRanasaleh @xenaalabbas @01sth02 @JMGardnerMD @Greg_Charville Favor MPNST. Great location, and the immunoprofile fits (CD34+, negative nerve sheath markers in higher grade tumors). Too fascicular for SFT, odd place for monophasic synovial sarcoma, which is usually CD34-.

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David Meredith@NeuropathDM·3 Nis

@DrJPLow @JaredAhrendsen @DrGeeONE @neuropathology @PriyankaKembha3 @Path4People @TristanRutland7 Papillary glioneuronal tumor has to be at the top of the differential. The location and perivascular cuboidal cells are classic.

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Julia P Low@DrJPLow·2 Nis

Call for #neuropath help: 60M Temporal lobe, cystic lesion, No necrosis, no mitoses, no MVP. IDH R132H neg, CD34+, EMAn neg, GFAP/Olig2 positive BRAF V600E neg. ?PLENTY ?Papillary glioneuronal tumour #pathtwitter #pathx #pathology

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Keith Ligon@KeithLigon5·19 Eyl

Not before your pathologist does! Important opportunity for pathologists and other diagnosticians to communicate their results directly to patients and explain results. Patients need to advocate for this as it’s not currently supported by insurance. #pathology

Sumathi Reddy@rddysum

When you see your health test results before your doctor? It's the law. My latest: wsj.com/health/wellnes… via @WSJ

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David Meredith@NeuropathDM·4 Ağu

Glad to finally have our work on ROS1-rearranged gliomas in diverse age groups published! #Neuropath #PathTwitter #pathX #pathology sciencedirect.com/science/articl…

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David Meredith@NeuropathDM·7 Tem

Thanks for including me in this exciting work!

Kun-Hsing Yu@kunhsingyu

Excited to share our new paper: AI and digital pathology enable real-time diagnoses and molecular subtype predictions during cancer surgery. cell.com/med/fulltext/S… @MacNasrallah @JuzZ_AI_Mopho ChengCheTsai @NeuropathDM @ElianaMarostica @KeithLigon5 @Jeff_golden1 @HarvardDBMI

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BWH Neuropathology@BWHNeuropath·16 May

Partially demyelinated axons of the cauda equina in the setting of Powassan Infection, presented by our Clinical Fellow, Dr. Kate Krause @pathonthewing #neuropathology #neurotwitter #infectiousdisease

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Brendan Dickson, MD@B_C_Dickson·13 May

MALIGNANT PERIPHERAL NERVE SHEATH TUMOUR. Underlying NF1. IHC: SOX10, H3k27me3. NB: spindle-epithelioid cells with pale amphophilic cytoplasm; ovoid-round nuclei with moderate pleomorphism and conspicuous mitotic activity; variable collagenous-myxoid stroma.

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David Meredith@NeuropathDM·13 Nis

@FelipePatologia PML - SV40/polyoma to confirm.

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Felipe D'Almeida@FelipePatologia·13 Nis

Adult patient with history of lymphoma, developed neurological symptoms and brain lesions. One of them was biopsied. The IHC is Ki-67. What do you think? Would you order any other stain(s)? #PathTwitter #Neuropath

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David Meredith@NeuropathDM·30 Mar

@M_Jikurashvili @atman_ci @JMGardnerMD @nusrat_xahra @nucleololailo I think you have to ignore the MDM2; it’s staining the endothelial nuclei strongly but is negative in the larger atypical cells.

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Manana Jikurashvili@M_Jikurashvili·29 Mar

Dear friends, This is a specimen of a 61y old lady with a destructive spinal mass, compressing the spinal cord. DDX: Aggressive Osteoblastoma VS Osteoblastoma-like osteosarcoma. How would you evaluate MDM2? #BSTPath @atman_ci @JMGardnerMD @nusrat_xahra @nucleololailo

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David Meredith@NeuropathDM·29 Mar

Rare example of chondroma arising in the dura (falx). Histo shows characteristic mature hyaline cartilage with increased cellularity and mild nuclear atypia. #pathology #PathTwitter #BSTpath #Neuropath

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David Meredith@NeuropathDM·27 Mar

Additional IHC (CD99+/des+/SSTR2-) was highly characteristic of Intracranial Mesenchymal Tumor, FET::CREB fusion positive. EWSR1 FISH showed rearrangement. This particular case has a solid growth pattern with no myxoid stroma. #Neuropath #pathology #PathTwitter #BSTpath

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David Meredith@NeuropathDM·23 Mar

Not all EMA+ tumors in the dura are meningiomas. Do you recognize this one? (EMA immunostain is shown for reference.) #pathology #PathTwitter #Neuropath #BSTPath

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David Meredith@NeuropathDM·27 Mar

@MariaGoobs Nailed it!

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David Meredith@NeuropathDM·23 Mar

A good clue is the presence of lymphoglandular bodies in the background. Smear prep is probably the best way to diagnose CNS lymphoma at frozen section. Here is the accompanying H&E permanent section and CD20. #PathTwitter #pathology #Neuropath #hemepath

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David Meredith@NeuropathDM·20 Mar

Can you diagnose in one cell? (Smear preparation from an enhancing deep white matter frontal mass in an older patient.) #Pathology #PathTwitter #Neuropath

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BWH Neuropathology@BWHNeuropath·19 Mar

Welcome to our new #PathMatch2023 AP/NP residents! Alicia Kenyon, MD from Sidney Kimmel Medical College at Thomas Jefferson Univ & Denis Smirnov, MD, PhD from Univ of California San Diego School of Medicine 🧠🔬#neuropath #PathTwitter @BrighamWomens @BostonChildrens @MGHPathology

Brigham and Women's Pathology@BWHPath

@BWHPath and @MGHPathology welcome 22 new residents to the Mass General Brigham Pathology Residency Program. We are thrilled that you will be joining us! Welcome to Boston. Congratulations to everyone who matched in pathology today! 🍾🎉 #PathMatch2023

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David Meredith@NeuropathDM·20 Mar

Nice example of a clear cell meningioma with the characteristic "blocky" collagen and absence of SMARCE1 expression.

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Entdecken

@HarvardDBMI @NIH @nigms @AmericanCancer @MAHoureih @DrJPLow @CraigHorbinski @JaredAhrendsen