Reality Check Marker

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Reality Check Marker

Reality Check Marker

@RealCheckMarker

Lifelong Learner. Award-winning Objective Thinker. Certified outer spectrum enthusiast. Social mediaholic. Yes, my profile pic is middle finger of Galileo.

RealityCheckMarker Bsky Joined Ağustos 2019
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Reality Check Marker
Reality Check Marker@RealCheckMarker·
"Cell-cell spread. Invisible to your humoral immune system." SARS isn't only invisible to antibodies. The virus will be invisible to detection. Same as HIV. Only the biomarkers of the damage being done can detect a persistent SARS infection. Same as HIV. #AirborneAIDS
David Joffe MB BS (Hons), PhD, FRACP 🇦🇺@DavidJoffe64

The shift in multiple genomics and proteomics in JN1 is all about walking passed our mucosal immunity (why bother) and then evading our primary immune responses. From there? Cell-cell spread. Invisible to your humoral immune system. Keep saying 🧬 Crystalline structures = LC🙏🏻

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sean stidston
sean stidston@seanstidston·
LC and M.E patients shouldn’t be given immunosuppressants without in-depth antibody testing and phenotyping. SFN shouldn’t be assumed to have an autoimmune basis with out this. I’m dealing with the consequences of immunosuppressants.
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Reality Check Marker retweeted
WHO/Europe
WHO/Europe@WHO_Europe·
“Long COVID isn’t just being tired.” For Matjaž it means cognitive decline, GI issues, sleep problems—and needing recovery time after simple tasks. These lived experiences shaped WHO Europe’s Long COVID Mythbusters, created alongside patients. 👉 More: bit.ly/3O6Ji3X
GIF
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CIDRAP
CIDRAP@CIDRAP·
New COVID variant with immune escape potential confirmed in US & 22 other countries. BA.3.2 represents a new lineage of SARS-CoV-2, genetically distinct from the JN.1 lineages that have circulated in the US since January 2024. Read more: ow.ly/ycA150YxOSw Credit: NIAID
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Harry Spoelstra
Harry Spoelstra@HarrySpoelstra·
🚨I've been warning for YEARS: COVID wrecks your HEART long-term, even mild cases! New European Heart Journal study confirms it: ↑ risk of heart attack & stroke for up to 3 YEARS. 😡Told you so! This isn't over. Please protect yourselves: YOU ONLY HAVE ONE HEART! 🧵👇 #AvoidSars2 #AvoidReinfections #COVIDisAirborne #CleanAirNow
Roger Gustafsson WHN|bsk.social@RogerGustafsso2

1/ The long term heart risks of C-19 💔 A massive new study in the European Heart Journal confirms what many feared: SARS-CoV-2 is not just a respiratory virus. It’s a long-term cardiovascular threat. The risk of major heart events remains elevated for years after infection.

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Reality Check Marker
Reality Check Marker@RealCheckMarker·
Totally just transient #AirborneAIDS - temporary AIDS - until the next infection. #WearN95
Vipin M. Vashishtha@vipintukur

A large study of over 40,000 people found that COVID-19 infection can cause long-lasting changes in immune cells, particularly lymphocytes. ➡️ Some immune cell levels remained below normal even 20 months after infection. ➡️ Researchers observed significant drops in T cells, CD4⁺ T cells, CD8⁺ T cells, NK cells, and B cells during infection, with incomplete recovery long after. ➡️ These immune changes may contribute to persistent symptoms seen in #LongCOVID. 1/

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Science Magazine
Science Magazine@ScienceMagazine·
Long Covid affects people of all ages and includes a myriad of post-acute and long-term adverse health effects caused by the infection. ⁠ ⁠ A 2024 #SciencePerspective highlighted the efforts made to understand this public health concern, what is known about the condition, and its wide-reaching effects on the risk of developing other chronic diseases. ⁠ Despite increasing knowledge of the mechanisms, epidemiology, and prevention, several challenges remain. First, the care needs of people experiencing Long Covid are consistently not met, and patients are often met with skepticism and dismissal of symptoms. Second, the lack of consensus on terms, definitions, and clinical trial endpoints for Long Covid, as well as the lack of animal models that can capture the breadth of Long Covid phenotype, are slowing progress and hampering the discovery of drugs that could improve patient health.⁠ ⁠ Addressing these challenges would not only provide insights into Long Covid but also other infection-associated chronic illnesses that have underappreciated long-term health impacts like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).⁠ ⁠ Learn more on #LongCovidAwarenessDay: scim.ag/3DCyV2Q
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Zdenek Vrozina
Zdenek Vrozina@ZdenekVrozina·
This Long COVID study feels scary for a reason - it hits an immune axis immunologists already know from HIV, HBV, sepsis, and cancer. That makes the result more biologically plausible, not less🧵
Prof. Dr. Sanjeev Bagai@BagaiDr

frontiersin.org/journals/immun… transcriptional signatures, LC-ME/CFS patients exhibited a mark⬇️ in naïve CD4+ and CD8+ T cells, regulatory T cells, MAIT cells, γδ T cells, & expansion of effector T cells. NK cells display⬇️ frequency and altered activation-associated transcriptional factors, consistent with⬇️ cytotoxic potentials. B cells in LC patients exhibited gene expression profiles indicative of heightened activation, while plasma cells revealed a distinct transcriptional subset expressing NK-associated genes. Platelets and low-density neutrophils were expanded and exhibited enrichment of activated-related transcripts. Monocyte subsets hv transcriptional skewing characterized by⬇️ expression of phagocytosis-associated genes and increased expression of pro-inflammatory cytokine-related genes/pathways. In contrast, idiopathic ME/CFS patients exhibited less pronounced immune alterations at transcriptional level: while T cell activation was evident, there was no reduction in MAIT or NK cells, nor signs of T cell exhaustion. FOXP3 expression was upregulated, and B cells and platelets demonstrated dysregulated signatures in idiopathic ME/CFS. Galectin-9–TIM-3 interaction as a potential pathway driving γδ and MAIT cell depletion in LC.

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Fe.
Fe.@NoHealthNoFun·
@RealCheckMarker @NotOstriching Okay… so we’re expecting a similar playbook, right? Years of very limited testing until the moment practitioners can profit from a potentially helpful treatment and are then encouraged to extend testing to a broader target group - correct?
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Vipin M. Vashishtha
Vipin M. Vashishtha@vipintukur·
New research finds that SARS-CoV-2 spike protein can persist in the gut of people with #LongCOVID, even months after infection. ➡️ This persistent viral antigen may drive ongoing immune changes in intestinal tissue. ➡️ Scientists detected viral spike RNA and protein in colon and ileum biopsies from Long COVID patients. ➡️ In these regions, genes linked to inflammation, immune dysfunction, and tissue stress were altered. 1/
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CoronaHeadsUp
CoronaHeadsUp@CoronaHeadsUp·
Study: "We confirmed the persistence of SARS-CoV-2 Spike transcript and protein in the gut tissue of all LC cases and controls tested" Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies bioRxiv biorxiv.org/content/10.648…
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Harry Spoelstra
Harry Spoelstra@HarrySpoelstra·
🚨Kids aren't immune to Long COVID. New Australian modelling study: ➡️"Vaccination of children 6 months to 11 years can reduce the burden of LC in this age group, especially at high coverage rates. " ➡️"Recurrent infections in children may result in an ongoing or increasing burden of chronic disease and disability, so vaccination policy should consider LC prevention." Thanks: @Globalbiosec et al.👏 #LongCOVID #KidsHealth #ProtectChildren sciencedirect.com/science/articl…
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Reality Check Marker
Reality Check Marker@RealCheckMarker·
@NoHealthNoFun @NotOstriching The tests were initially expensive and extremely limited. For example, a female could hardly get permission to get tested for HIV since she wasn't a gay man.
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Harry Spoelstra
Harry Spoelstra@HarrySpoelstra·
🤔 Long COVID isn't AIDS—but it is rapid-onset "AIDS-like": the same NK-cell exhaustion, chronic immune dysregulation, mucosal collapse, and failed coordination as in HIV, just without the retrovirus and on fast-forward!😷 ZDENEK: A "Post-acute immune dysregulation syndrome (PAIDS)" may be a fitting new label! 🤔🧵👇
Zdenek Vrozina@ZdenekVrozina

When the findings of the NK cell study are viewed alongside well-established phenomena from HIV immunology, the parallels become difficult to ignore. Long COVID is not a classic slowly progressive retroviral immunodeficiency, but the comparison helps refine the mechanistic similarities again. @SalamonSMD 🧵

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Denis - The COVID info guy -
Denis - The COVID info guy -@BigBadDenis·
Study: "SARS-CoV-2 causes lasting immune dysregulation for over 20 months" Large multicenter study finds SARS-CoV-2 exposure causes long-term immune changes affecting CD4+, CD8+, NK, and total T cells, persisting up to 20 months. Source: sciencedirect.com/science/articl…
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Arturo Portnoy
Arturo Portnoy@portna·
So, airborne AIDS?
Vipin M. Vashishtha@vipintukur

A large study of over 40,000 people found that COVID-19 infection can cause long-lasting changes in immune cells, particularly lymphocytes. ➡️ Some immune cell levels remained below normal even 20 months after infection. ➡️ Researchers observed significant drops in T cells, CD4⁺ T cells, CD8⁺ T cells, NK cells, and B cells during infection, with incomplete recovery long after. ➡️ These immune changes may contribute to persistent symptoms seen in #LongCOVID. 1/

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Winterish
Winterish@LostSock·
“Depletes immune cells.” You gotta love the way they word these things. I guess if they said “immunodeficiency” and “virus” in the same sentence, people might start making connections. Trending now on X.
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@BCarfree @seanstidston @fitterhappierAJ @NoHealthNoFun @NotOstriching @Globalbiosec @elonmusk @BarackObama