Derek Croote

540 posts

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Derek Croote

Derek Croote

@DerekCroote

Co-founder & CTO of clinical-stage antibody therapeutics co @IgGenix | Following trials with @trialinference | Previously @Stanford bioengineering PhD

Bay Area, CA Inscrit le Mart 2018
1.2K Abonnements549 Abonnés
Derek Croote
Derek Croote@DerekCroote·
@OpenAI Are the benchmarks run with the Life Sciences plugin enabled? And does the plugin materially change results e.g., does the GPT-5.5 delta to GPT-Rosalind meaningfully narrow with the plugin? Maybe @ChrisHayduk you might know?
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OpenAI
OpenAI@OpenAI·
We’re bringing new capabilities to GPT-Rosalind, a model series purpose-built for life sciences research at enterprise scale. It brings GPT-5.5’s agentic coding and tool use together with stronger intelligence for drug discovery, analysis, design, and experimental workflows. openai.com/index/introduc…
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Derek Croote
Derek Croote@DerekCroote·
Nice to see Claude Opus 4.8 refusing fewer biology questions than 4.7. It's now also recognizing the error-prone nature of correctly reproducing long sequences: "I can't provide the exact full amino acid sequence of... as I'm not confident I can reproduce it with the precision required. Sequence data like this is the kind of information where small errors (a single wrong residue) can be significant, and I don't want to give you something that looks authoritative but contains mistakes."
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Derek Croote
Derek Croote@DerekCroote·
More journals should offer manuscripts in both human-readable PDF and machine-readable XML like @MDPIOpenAccess does.
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Niko McCarty.
Niko McCarty.@NikoMcCarty·
We should manufacture drugs and vaccines using duckweed. A few reasons: - They're the fastest-growing flowering plants. - Duckweed is up to 45% protein by biomass. - They grow in wastewater. - Duckweed can be transformed by "dipping" them into a liquid with plasmids and carbon nanotubes; very simple. - Both monoclonal antibodies and edible vaccines have been made with duckweeds at small scales for ~two decades. But there are lots of duckweed strains. We should sequence all of them, pick a strain, and start building better biotechnology tools. There is room for a focused philanthropy effort here (and companies), too.
Niko McCarty. tweet mediaNiko McCarty. tweet mediaNiko McCarty. tweet media
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signüll
signüll@signulll·
when i shop on amazon i carefully look for trusted name brands… brands like ZDFKEA & RTUARL... you know familiar household names. it makes me feel like i’m buying a mission, not just a product.
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owl
owl@owl_posting·
trad bio companies are a no-fun-allowed zone, but the one exception is the naming of their clinical trials. here, they are allowed to have a little clever wordplay. Gritstone Bio calling their trials SLATE and GRITSTONE. Madrigal Pharma naming theirs MAESTRO. it's all very cute
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Derek Croote
Derek Croote@DerekCroote·
exceptional clinical trial title
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Sholto Douglas
Sholto Douglas@_sholtodouglas·
When do you reach for other models instead of Claude? What can we do better? Hit me with all of your frustrations. dms open. If you can give me detail (e.g. specifics/transcipts) - it'll help a lot in finding out exactly what we need to do to improve the next model
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Derek Croote retweeté
Convoke
Convoke@Convokebio·
Today we're publishing our index of unmet needs in human disease: 2443 indications scored and ranked on burden of disease, prevalence, pipeline activity, and treatment burden. We hope this will help drug developers identify overlooked medical problems convoke.bio/blog/introduci…
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Derek Croote
Derek Croote@DerekCroote·
yep seems to be it
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Derek Croote
Derek Croote@DerekCroote·
after repeatedly trimming and simplifying the prompt, the conclusion is that claude doesn't like post-translationally cleaved proteins. [diff below shows the deletion necessary for claude to not refuse the prompt; no data was attached to prompt]
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Derek Croote
Derek Croote@DerekCroote·
Genuinely bewildered. Claude refusing to analyze ELISA and SPR binding data. I even tried removing (contentious ??) terms like "antibody" and "antigen"
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Derek Croote
Derek Croote@DerekCroote·
@patrick_oshag from the 80s, but quite good. the cuckoo's egg: tracking a spy through the maze of computer espionage
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Patrick OShaughnessy
Patrick OShaughnessy@patrick_oshag·
Anyone read anything really great lately (any format)?
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Sam Altman
Sam Altman@sama·
what would you most like to see improve in our next model?
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nabbo (bio/acc)
nabbo (bio/acc)@TensorTwerker·
Does anyone have Protenix-v2's weights? I'm geo-blocked from Chinese CDN. @ByteDanceOSS
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unusual_whales
unusual_whales@unusual_whales·
BREAKING: California gas prices hit $6 per gallon, per CNBC
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