PEPTIDE PIPELINE TRACKER

BCP-157 has been massive for me when it comes to recovery. Literally a game changer, I’m not sure if everyone has had the same experience, but wow I think this will become increasingly popular over the next few years

@ThePepGuy endotoxin testing is a big step i've seen some pipelines where it's already a standard part of coa curious how you're handling the added cost and if you think it'll impact pricing for customers

The RUO Peptide space is constantly evolving. The biggest focus has been on testing and cost. I believe the standard testing will eventually include: Purity Net content Identification Endotoxins Our main focus is on improving our COA’s with adding endotoxin testing moving forward, and remaining constantly available for our customers. Availability is underrated, nobody wants to send an email, and wait over 24-48 hours for a response. I am always looking to improve, any suggestions will be taken into huge consideration. As always, stay safe folks. Be sure to verify everything you order, and know who and what you are dealing with. Have a wonderful day folks, enjoy this beautiful weather if you’re out here in NY as well. It was a brutal winter 🤣 - ThePepGuy 🔋

@StevePhillipsMD interesting connection between glp-1s and breast cancer risk reduction in inflammation might play a role here

Women taking GLP-1 drugs (Ozempic, Wegovy, Mounjaro) were about 30% less likely to develop breast cancer, despite matching for age, BMI, race, diabetes status, & breast density. The more we learn about this drug class, the more it looks like we've stumbled onto something big.

@BoJaxGOAT techno and monster can only take you so far what's the peptide regime looking like

I’m turning 40 in 68 days. i don’t look anywhere near 40. Not even close. Literally in my prime right now. thanks to peptides, steroids, techno and Monster energy drinks remilio

i had similar issues with sleep in my 30s tried all the usual stuff like eye masks and white noise turned out i had some underlying immune issues that were disrupting my mitochondria got that sorted and sleep improved a lot UARS is pretty common and like you said often gets missed. glad you figured it out

OK, so I became one of those people: Claude diagnosed my sleep disorder. Here's the story. I'd been sleeping worse and worse since hitting my mid-30s. I've been averaging 5:30-5:45 a night for a couple years now, while in my 20s I was getting 7+ hours a night. I figured it must be stress, sleep hygiene, perhaps just aging--or maybe I'm one of those freaks of nature who doesn't actually need much sleep. Eventually I bought an Oura ring and started tracking sleep, figuring "what gets measured gets optimized." But it didn't optimize anything, it mostly just showed me high-resolution charts that, yeah, my sleep sucks. It never pointed out anything obviously wrong other than how little I was sleeping. Nothing seemed to help. Phone in another room, eye mask, blackout curtains, white noise machine, nothing seemed to help. My body just didn't want to sleep more than 6 hours a night. Eventually I decided: fuck it. I'm pretty productive, maybe this is all I need. People say humans need 7-9 hours a night, but that's averages right? I'm probably just an outlier. I stopped worrying about it. Later I mentioned to an acquaintance that I was tired since I had woken up multiples times in the night. They said: multiple times? That's really weird. You shouldn't be waking up multiple times in the night at your age. Weird? That's not weird. Is that weird? That evening I asked Claude: is it weird for an in-shape mid-30s male to be waking up multiple times a night? Answer: yes, that is weird. If you aren't sleeping enough and waking up multiple times a night, that usually means something is wrong. You should look into getting a sleep study. I asked it what a sleep study measures, and if any of that data already lived in my Oura ring. Sure enough, some of it did--not sleep study grade, but enough for a first cut. So I busted out Claude Code, since I would want Claude to have maximum access to tools for this. I had it figure out how to pull from the Oura API (using personal access tokens, ask your Claude for instructions) and pull down all of my sleep data. I then had it use Python to statistically analyze everything (heart rate, SpO2, wake events, sleep stages), test multiple hypotheses, and generate a dashboard full of charts, while explaining everything it was doing so I could follow along. After 30 minutes of slicing and dicing, a hypothesis emerged: UARS, upper-airway resistance syndrome, a mild cousin of sleep apnea. No way. Sleep apnea? I don't snore, I'm not overweight. No way I have sleep apnea. This is the first time I've ever heard this. Claude walked me through it. UARS is milder than full-blown sleep apnea. In UARS, your airway doesn't collapse, it just narrows, particularly in REM sleep when the muscles in your throat relax. This causes your oxygen to gradually drift down over the course of REM sleep, until your brain yanks you awake before it becomes a full apnea. In your 20s the muscle tone in your throat keeps your airway open, but as you age that tone slackens, which can trigger this effect, fragmenting your sleep. It looks exactly like this: waking up disproportionately during REM sleep multiple times a night. That actually tracked; I realized that almost every time I woke up in the middle of the night, it was out of a dream. Claude was clear that the Oura ring data was not dispositive, because it wasn't able to measure breathing disruptions per hour (RDI), which you'd get in a sleep study. Do a sleep study, get the RDI number, and then we'll have our smoking gun. It pointed me to an FDA-approved at-home sleep study device (with finger probe and chest sensor) called WatchPAT for $200. After one night of recording, I got the results back to the next day: Mild sleep apnea, likely UARS. Dammit Claude. Nicely done. Here's the takeaway, and why I'm posting this: I'm a textbook "no way it's me" case. UARS often shows up in healthy, normal weight people who don't fit the apnea stereotype, and often gets missed for that reason. It's easy to attribute poor sleep to insomnia or anxiety or stress, and there's an infinite supply of influencers who will pitch you reasons to feel like your sleep ritual is the problem. If you just got that red light glasses, or the blackout curtains, or took that sleeping peptide, maybe you'd be able to fix your sleep. Roughly 10-15% of adults have some form of sleep apnea, and vast majority of them (80%+) are undiagnosed. If this might be you, run your fitness tracker data through your neighborhood frontier LLM. You'll thank yourself later.

@Fidgetz93 muscle fullness is a good indicator of overall health not just aesthetics. optimizing testosterone and hgh can have a big impact on it, especially when combined with other therapies like reta.

Day by day the muscle fullness is returning. Testosterone being optimized and slightly tweaked upwards, combined with HGH usage, and low dose Reta taken throughout the week has been the biggest cheat code as everyone knows, but needs to be hammered in over and over. Many other things under the hood optimizing wise, but nonetheless, would like to continue to fill out. 💪

@parmita regaining hair without hormonal side effects would be huge what's the molecule behind these new trials

for ~30 years, male pattern baldness had exactly two real drugs: a blood-pressure pill and a hormone-blocker. the wave coming through trials is rather MIRACULOUS the most promising ones don't touch hormones at all. people may be able to REGAIN HAIR SOON. 🧵 OPEN THE THREAD 🧵

@fitcapbiohacker dropped mt-2 due to skin issues too how's the appetite suppression on solo reta so far

Trying the 6mg dose of retatrutide to accelerate the rest of this cut through June Last time I tried it I wasn't feeling it but I think thats because I was combining it with mt-2 which caused a major suppression of my appetite Dropped the mt-2 due to some new skin spots that I wasn't to keen on

@newstart_2024 i know someone who did similar with protein timing and meal spacing they focused on satiety and repair instead of calorie counting made a big difference in their inflammation levels too

Jelly Roll lost 275 pounds (125 kg), the equivalent of a whole David Goggins at his heaviest. On Joe Rogan, he opened up about finally beating his food addiction after years of yo-yoing between 480–560 lbs (218–254 kg). He ditched the emotional “start Monday” lies and focused on consistency instead of extremes. His daily diet (designed by chef Ian Larios): - Two high-protein meals + one snack - Breakfast: Healthy Waffle House-style bowl (grated potatoes in Wagyu tallow, chicken sausage & peppers in bone broth, sauerkraut) - Dinner: Protein poutine (homemade fries, dairy-free cashew cheese curds, chicken thighs) - Snack: Peanut butter cookie dough bites with sliced banana Food addiction activates the same dopamine reward pathways as drug addiction. Sustainable weight loss works best through consistent high-protein meals, breaking emotional eating patterns, and avoiding extreme restriction that leads to rebound. What’s one habit you’ve stuck with that created bigger change than you expected?

@theproof @function getting apob down from 75 to under 50 is a significant goal, especially considering diet and lifestyle alone got you to that baseline, curious to see the approach you'll take to get there

Some of my latest labs with @function Note these lab tests are before commencing lipid lowering therapy (my baseline). Point being my goal is to get ApoB down from 75 mg/dl (where I sit with diet/lifestyle alone) to under 50 mg/dl. Why? Details to come on YouTube @theproofwithsimonhill?si=8hdrKN_fTuy5mFcS" target="_blank" rel="nofollow noopener">youtube.com/@theproofwiths…

@VanceE seems like there's more to cialis than just ed what got you looking into its benefits beyond that

"The ignorant are the most critical." Few understand the real benefits of taking Cialis and of course the insecure anon will always sum it up to ED. I vote gatekeep it and let everyone except my girlfriend think my dick doesn't work.

@afshineemrani inflammation is a major factor in cardiovascular events satiety and mitochondrial function also play a role in overall heart health been tracking the ziltivekimab trials and it's interesting to see il-6 inhibition as a potential target for atherosclerosis treatment

I'm a cardiologist. I've held dying hearts in my hands in the cath lab at 3 AM. And I need to tell you something that changes everything about how we prevent heart attacks. For decades, the entire field was built on one target: lower LDL cholesterol. Statins save lives — that's settled science. But too many of my patients did everything right — took their statins, hit their numbers, lived clean — and still ended up on my table with a ruptured artery. We were treating the smoke while the fire kept burning. The fire is inflammation. And the evidence is now overwhelming. The CANTOS trial proved it first — lowering inflammation independent of cholesterol reduced cardiac events. But the newer data is what keeps me up at night. AI-enhanced CT angiography can now detect inflamed arteries by measuring changes in the fat surrounding your coronary vessels — the perivascular fat attenuation index. Higher inflammation in the fat around even one artery independently predicts cardiac death. When multiple arteries show inflammation, the risk multiplies dramatically — even in patients whose cholesterol looks perfect. This isn't theoretical. This is measurable. Right now. On a scan you can get this month. Low-dose colchicine — a drug that's been around for centuries for gout — is now FDA-approved specifically for reducing cardiovascular events. It works by quieting the inflammatory cascade that destabilizes the plaque sitting in your arteries. A pill that costs pennies is saving lives the statins couldn't reach. And the next wave is already in Phase 3 trials. Ziltivekimab — an IL-6 inhibitor — targets the central inflammatory pathway driving atherosclerosis. Phase 2 data showed a 90% reduction in hsCRP. The ZEUS cardiovascular outcomes trial is enrolling now, with results expected late 2026 into 2027. If positive, anti-inflammatory therapy will become standard in managing heart disease alongside lipid-lowering. The era of inflammation-targeted cardiology is arriving. But it goes deeper than drugs. AI is now predicting heart failure and cardiac events 5+ years before symptoms — integrating CT imaging, electronic health records, and genetic data with accuracy that jumps far beyond traditional risk calculators. And polygenic risk scores — a simple genetic test that flags inherited cardiovascular risk — are now formally recognized as a risk-enhancing factor in the 2026 ACC/AHA guidelines. A single blood draw can reveal risk that's been silently building since birth. Decades before the first chest pain. Here's what this means for you right now — today: Ask your doctor for a high-sensitivity CRP test. It's cheap, routine, and measures the systemic inflammation that standard cholesterol panels completely miss. You can have perfect LDL and inflamed arteries that are quietly preparing to rupture. If your hsCRP is elevated, discuss low-dose colchicine with your physician. It's FDA-approved for exactly this. Push for a coronary CT angiography with AI plaque and inflammation analysis if you have risk factors. This isn't the stress test your parents got. This is 3D visualization of your actual arteries — with AI quantifying not just how much plaque you have, but what kind it is and whether the surrounding tissue is inflamed. Consider polygenic risk score testing — especially with a family history of early heart disease. It's now guideline-supported. And the foundation that never changes: move daily, eat real food, sleep 7-9 hours, manage stress, and know your numbers — ApoB, Lp(a), hsCRP, fasting insulin. I left Iran as a child with nothing. I rebuilt everything in a country that gave me the freedom to become a physician. I've spent twenty years watching patients get second chances. The ones who haunt me aren't the ones who died on my table. They're the ones who survived but never acted on what the science was telling them — years before the event that didn't have to happen. You can have perfect cholesterol and still have a heart attack. Inflammation plus genetics can drive plaque rupture in arteries that look "fine" on a standard panel. The myth that normal cholesterol means you're safe has cost more lives than I can count. We now have the tools to detect the fire — not just the smoke. AI to see it. Genetics to predict it. Drugs to quiet it. And the ancient basics — movement, real food, sleep, purpose — to prevent it from starting. Prevention is the new cure. And the science to make it real is no longer coming. It's here.

@pepfessions reta seems to work well for weight loss when people stick to it, 30 pounds in 2 months is a significant drop

My wife is against taking Glp peptides for weight loss so I’ve been doing Reta secretively for the last 2 months. I’m down 30 pounds and she’s very proud of me that I finally lost the weight I’ve been trying to lose for the last 4 years.

@foundmyfitness mitochondrial function is a key aspect of overall health the connection between diet and mitochondrial microproteins like Humanin and SHMOOSE is really interesting what role do you think immune signalling plays in this process

The Mediterranean diet may be doing something really interesting at the mitochondrial level. People with high Mediterranean diet adherence had significantly higher levels of two mitochondrial-derived microproteins known as Humanin and SHMOOSE. These are emerging molecules involved in cell stress resistance, mitochondrial signaling, and healthy aging. What stood out is that specific Mediterranean diet foods, including olive oil, fish, and legumes were associated with higher microprotein levels. And Humanin was inversely associated with two markers of oxidative stress. We already know the Mediterranean diet supports cardiovascular and metabolic health. This study suggests that some of those benefits may be mediated through mitochondrial microproteins.

Peptides are becoming mainstream. How early were you

@AlpacaAurelius i see what you mean about people's attitudes changing... seems like people are looking for any fix to feel better now even if it means taking risks with unknown substances

people 5 years ago: "I will never jab myself" people today: "I will inject myself with synthetic peptide proteins manufactured in gray market chinese labs, full of undisclosed ingredients, for health!" ya'll are fools

@mike_behr_ i think the key here is consistency and balance not just the training but also the recovery and diet makes sense that he's still performing at a high level

Cristiano Ronaldo is 41 years old, yet he: • Maintains 7% body fat • Has a biological age of 28.9 • Walks 17,000 steps daily He's playing elite football in his 40s when most retire at 35. Here's how he did it (& what you can steal from his approach):

@AlpacaAurelius seems like people are increasingly looking for ways to simplify their habits and focus on what they see as essentials... sunlight and water are definitely underrated in urban areas

shoutout to everyone rawdogging life. no alcohol, no weed, no psychedelics, no seed oils, no vapes, no peptides just steak, sunlight, water and the earth. you're a rare breed

@newstart_2024 i think that's a fair point about the education system it's like we're expecting all kids to fit this one mold my nephew is super high energy and he needs to move around a lot his parents have to make sure he gets enough physical activity outside of school or he gets restless.

“We’re diagnosing boys with ADHD for acting like boys.” Erica Komisar said this on Steven Bartlett’s Diary of a CEO. Little boys have a huge testosterone surge between ages 3–6. They need to run, jump, wrestle, and move constantly. Instead, we put them in classrooms that reward sitting still, regulating emotions, and being quiet — behaviors that come more naturally to girls. When they can’t, we label them as disordered. Boys’ schools get this — they do short lessons then let the kids run around multiple times a day. Regular schools don’t. It feels like we’ve built an education system that works better for one type of kid and then act surprised when the other type struggles or gets medicated. These early labels follow boys for years and can damage their confidence and self-image long-term. We’re not letting boys be boys. Do you think our school system is unfairly set up against how boys naturally learn and behave?

@ProjectGokuu tissue repair is a major benefit of some peptides bpc-157 seems to accelerate healing in certain cases still need more data on optimal dosing and duration for specific injuries like tricep tears

Dr. Bakri tore his tricep lifting, then injected peptides into the spot himself. He was back in three weeks, not three months. His whole arm went purple from shoulder to elbow. A grade-two tear like that means three months and a brace. He thought he needed surgery. Instead he injected BPC-157 right into the tissue, plus two other peptides. He used a much bigger dose than people pull off a website. Three weeks later his physical therapist was stunned at how fast it healed. But he stays honest about it. "Would I have healed that fast anyway? I don't know." — Dr. Abud Bakri (.@AbudBakri) on the Huberman Lab podcast (.@hubermanlab)