Pascal Martin
2.7K posts
@PgpMartin
Senior Research Specialist (IR) @INRAE_France Gene Expression #genomics #transcription #chromatin #bioinformatics #rstats @pgpmartin.fr on bluesky Tweets my own
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
Happy to introduce AlphaGenome, @GoogleDeepMind's new AI model for genomics. AlphaGenome offers a comprehensive view of the human non-coding genome by predicting the impact of DNA variations. It will deepen our understanding of disease biology and open new avenues of research.
Genome annotation is falling behind how fast genomes can be assembled—but Johns Hopkins researchers @KuanHaoChao, @StevenSalzberg1, @elapertea, @alaina_shumate, @celinehohzm, & @alan_mayonnaise (+ @JakobHeinz9) have created a tool that can change that: cs.jhu.edu/news/solving-t…
📢 Introducing Biomni - the first general-purpose biomedical AI agent. Biomni is built on the first unified environment for biomedical agent with 150 tools, 59 databases, and 106 software packages and a generalist agent design with retrieval, planning, and code as action. This enables Biomni to perform a wide range of research tasks - from literature review, hypothesis generation, protocol design, data analysis, clinical reasoning, and much more - across subfields like genomics, microbiome, physiology, and beyond. Some key results: 🔬 Designed a molecular cloning experiment validated in wet lab, matching the performance of a >5-year expert in a blinded test 📊 Completed a wearable bioinformatics analysis across 458 messy files in 35 min vs. 3 weeks by a human 🧠 Uncovered novel transcription factor hypotheses driving skeletal lineage regulation We built a web platform where biomedical scientists can immediately delegate their tasks to the agent today, completely free! 🧪 Try it now: biomni.stanford.edu 📄 Paper: biomni.stanford.edu/paper.pdf 💻 Code: github.com/snap-stanford/… (will be fully open-sourced very soon!) 💬Join the community: tinyurl.com/biomni-slack Biomni is an open-source initiative: we invite the community to build on it and advance biomedical research at scale. With amazing collaborators @StanfordAILab @StanfordMed @StanfordCancer @genentech @arcinstitute @UCSF @UW @PrincetonAInews @serena2z @hcwww_ @YuanhaoQ @mintaylu @yusufroohani @RyanLi0802 @LinQiu0128 Gavin Junze Di Shruti Jennefer Xin Zhou @MWheelerMD Jon Bernstein @MengdiWang10 @PengHeAtlas @SnyderShot @lecong Aviv Regev @jure
