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Sleep regularity may matter more than sleep duration. Using wearable data from >60,000 adults, sleep regularity was a stronger predictor of mortality risk than sleep duration. Pick a consistent bedtime and protect it as much as possible.

Visual for kids to make better understand delayed gratification.

Is coffee helping or harming our patients’ hearts? In the latest episode of the Beyond Journal Club podcast from @COREIMpodcast and NEJM Group, the hosts unpack the CRAVE trial and use it as a lens to answer a bigger question: How should clinicians interpret nutrition research, especially when it feels inconsistent or hard to trust? Listen to the full episode for a concise, practical framework you can use the next time a patient asks about coffee, diet, or lifestyle: coreimpodcast.com/2026/04/15/nut… 📖 Further reading Original Article by G.M. Marcus et al.: Acute Effects of Coffee Consumption on Health among Ambulatory Adults (CRAVE trial) nejm.org/doi/full/10.10…

It appears that a historic deal is within reach, and it will hold if President Trump is willing to enforce the restrictions he’s placed on Israel. This post indicates a good start—but it must be followed by actually limiting U.S. military aide to Israel.

Agentic commerce isn’t priced in yet. Machine-to-machine payments will increase demand for the digital dollar beyond current estimates. The agentic economy could be larger than the human economy. We're building the infrastructure for both at Coinbase.

Getting in shape is like investing. The more you do it when you're younger the better off you'll be when you're older.

JUST IN: Catholic Pope Leo XIV says "the world is being ravaged by a handful of tyrants."

Pete Hegseth quoted a fake Bible verse from Pulp Fiction during a Pentagon sermon.

Creatine is not just for muscle. At the right dose, it may meaningfully support brain energy too. About 5 g/day is enough to keep muscle stores saturated, but research suggests around 10 g/day may be needed to meaningfully increase brain creatine. Doses used during sleep deprivation (around 0.35 g/kg body weight, often landing near 20–30+ g) have been shown to blunt or even reverse cognitive deficits under extreme stress. If you supplement, creatine monohydrate is the most studied form, and choosing an NSF Certified for Sport product adds an extra layer of quality assurance.

Best advice I got in my 20s: Nobody cares. When you’re winning, nobody cares. When you’re losing, nobody cares. Stop fearing the judgement of people who were never even thinking about you. Nobody is thinking about you. They’re too busy thinking about themselves. Go do the thing.

Woe to those who manipulate religion and the very name of God for their own military, economic, and political gain, dragging that which is sacred into darkness and filth. #ApostolicJourney #Cameroon vatican.va/content/leo-xi…

Your current struggle is just one chapter, not the whole story. Keep showing up!

Tennis players live 9.7 years longer than sedentary people. Not 9.7 months. 9.7 years. Nearly a decade. The Copenhagen City Heart Study tracked 8,577 people for 25 years and ranked every sport by how much life it adds. Badminton: 6.2 years. Soccer: 4.7. Cycling: 3.7. Swimming: 3.4. Jogging: 3.2. Tennis almost triples jogging. A separate study of 80,000 adults found racket sports cut all-cause mortality by 47% and cardiovascular death by 56%. Swimming hit 41%. Aerobics hit 36%. The question is why racket sports destroy everything else. Three mechanisms stack on top of each other. First, the physical demands. A tennis rally requires explosive sprints, lateral cuts, and sustained aerobic output. You're training fast-twitch and slow-twitch muscle fibers simultaneously. Most cardio only trains one system. Second, the cognitive load. You're reading spin, predicting angles, adjusting position, and executing motor patterns in real-time. Your brain is solving spatial puzzles at 80+ mph. That hand-eye coordination and strategic processing builds neural connections that protect against cognitive decline. Third, and this is the one researchers keep coming back to: you literally cannot play alone. Every racket sport requires another person on the other side of the net. That forced social interaction triggers neurochemical benefits that solitary exercise cannot replicate. Strong social connection alone increases your chance of longevity by 50%. Jogging is you and your thoughts. Tennis is you, a strategic opponent, and a community. Dr. Daniel Amen is right. The data is overwhelming. If you want the single highest-ROI activity for a longer life, pick up a racket.

A brief bout of physical exercise can create "ripples" of activity in your brain that help you store and retrieve memories. ow.ly/KFQk50YEsg6

Issues recognized with medical AI models —Problematic responses to 5 chatbots bmjopen.bmj.com/content/16/4/e… —Prediction based on unreliable, open-access datasets nature.com/articles/d4158…

The 10 AM "brain fog" isn't a caffeine deficiency. It’s a breakfast mistake. 🍳 Here is the metabolic chain reaction most people miss: 1️⃣ The Trigger: Skipping protein at breakfast. 2️⃣ The Spike: A carb-heavy start (or nothing at all) leads to a rapid glucose drop. 3️⃣ The Crash: Your brain loses its steady fuel source. The Result: Irritability, "false hunger," and a loss of focus. The Fix: Swap the cereal for a protein-rich beakfast. Aim for 30g of protein to "level the hills" of your glucose curve for the rest of the day. #MetabolicHealth #NutritionTips #PhysicianInsights

On the path to neurodegenerative diseases, the pivotal role of immune system activation. A new and excellent review @jclinicalinvest jci.org/articles/view/…

For years, the gold standard for spotting early Alzheimer’s was the amyloid PET scan, which could detect brain plaques 10 to 20 years before symptoms appeared. However, a groundbreaking study has identified a “pre-early” warning sign. Researchers found that a blood test for pTau217 (phosphorylated tau 217) can predict amyloid buildup and cognitive decline even when initial brain scans appear perfectly normal. This discovery could shift Alzheimer’s screening from expensive, invasive scans to a simple, scalable blood test during routine checkups. neurosciencenews.com/ptau217-blood-… #Alzheimers #neuroscience #health (1/3)

🚩🚩 DORMIR 6 HORAS AL DÍA NO ES SUFICIENTE Tras 14 días durmiendo 6h/noche, tu rendimiento cognitivo cae igual que tras 24h sin dormir 📉 Lo peor: – El deterioro es progresivo y acumulativo – Es lineal (cada día rindes peor) – Y no te das cuenta: la somnolencia subjetiva apenas sube. 💣 Dormir poco no te adapta… te deteriora.

Celiac disease is a chronic, small-intestinal, immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed persons. It is increasingly common, affecting persons of all ages, and has a wide geographic distribution. Learn more: nejm.org/doi/full/10.10…