Aram Chung

In cancer, activated T cells release abundant extracellular vesicles that transfer DNA to the nucleus of tumor and immune (dendritic) cells, turning tumors from cold to hot. An immunotherapy in the works. @Cancer_Cell sciencedirect.com/science/articl… sciencedirect.com/science/articl…

CAR-X cell engineering dlvr.it/TSG6WV

A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery go.nature.com/4ugPm9D

Macrophage senescence is a central driver of chronic inflammation in aging and metabolic liver disease, and a tractable therapeutic target.

In the latest issue! Hallmarks of cancer—Then and now, and beyond dlvr.it/TS4Plc

A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery #NBTNV go.nature.com/4s4X7P7 rdcu.be/fdfzQ

Steady progress towards engineering immune cells in the body now for refractory myeloma , with major implications for many autoimmune diseases and cancers nature.com/articles/s4159… nature.com/articles/s4159…

For readers interested in lipid nanoparticles for oligonucleotide delivery, here's an article covering 60 years of progress in the field rdcu.be/fb9xD nature.com/articles/s4157…

Cell senescence and how it predisposes to cancer, no less how we may be able to modulate it. An outstanding @CellCellPress review cell.com/cell/fulltext/…

Glad to share our new Nature Chemical Engineering article on new mechanisms for nanocarriers ! nature.com/articles/s4428…

Optimized mechanical stimulation provides a simple and effective strategy to counteract age-related bone deterioration and systemic inflammation nature.com/articles/s4146… @NatureComms 🇨🇳

Microfluidic Mechanical Reactivation of Aged Stem Cells biorxiv.org/content/10.648…

By hitching a ride on the body’s own red blood cells, a new delivery platform for in vivo CAR myeloid cells can bypass immune surveillance and efficiently deliver mRNAs to splenic immune cells for cancer #immunotherapy in mice. @Westlake_Uni scim.ag/48bzwV0

Studies of uterus transplant recipients reveal how immune cells shape pregnancy outcomes, an amino acid cocktail enhances nanoparticle delivery of therapeutic mRNAs in mice, and more this week in #ScienceTranslationalMedicine. scim.ag/3NgmFcX

"Safe and Efficient CRISPR Genome Editing of Primary Human T Cells Using a Droplet-Based Cell Mechanoporation Platform" Kim YJ, Bang S, Chung AJ. Small. 2026-02-05. doi.org/10.1002/smll.2… ... achieving up to a 2.35-fold higher efficiency than electroporation.

Now online! A post-assembly, reversible crosslinking strategy that enhances lipid nanoparticle-mediated mRNA delivery while preserving efficient intracellular release. Link ($): nature.com/articles/s4428… Free PDF: rdcu.be/e4elc

Eleven clinical trials that will shape medicine in 2026

Our editors pick their favorite research articles from 2025 go.nature.com/4oCK84L

CAR-T and NK cells engineered using a non-viral circular single-stranded DNA system show effective anti-tumor function go.nature.com/3ZLpoPb rdcu.be/eRy0K

Integrated epigenetic and genetic programming of primary human T cells go.nature.com/3WOJJAJ