Aram Chung

Studies of uterus transplant recipients reveal how immune cells shape pregnancy outcomes, an amino acid cocktail enhances nanoparticle delivery of therapeutic mRNAs in mice, and more this week in #ScienceTranslationalMedicine. scim.ag/3NgmFcX

"Safe and Efficient CRISPR Genome Editing of Primary Human T Cells Using a Droplet-Based Cell Mechanoporation Platform" Kim YJ, Bang S, Chung AJ. Small. 2026-02-05. doi.org/10.1002/smll.2… ... achieving up to a 2.35-fold higher efficiency than electroporation.

Now online! A post-assembly, reversible crosslinking strategy that enhances lipid nanoparticle-mediated mRNA delivery while preserving efficient intracellular release. Link ($): nature.com/articles/s4428… Free PDF: rdcu.be/e4elc

Eleven clinical trials that will shape medicine in 2026

Our editors pick their favorite research articles from 2025 go.nature.com/4oCK84L

CAR-T and NK cells engineered using a non-viral circular single-stranded DNA system show effective anti-tumor function go.nature.com/3ZLpoPb rdcu.be/eRy0K

Integrated epigenetic and genetic programming of primary human T cells go.nature.com/3WOJJAJ

Engineering and biofabrication of early cancer models bit.ly/4oKrMiM

How do you change a cold, immune evasive tumor into a hot one? erictopol.substack.com/p/how-mrna-vac…

Elucidating lipid nanoparticle properties and structure through biophysical analyses go.nature.com/4oTt639

Published today in @NatureBiotech, @LaineGoudy. @LukeGilbertSF, Alex Marson, and colleagues report a new epigenetic editing platform that safely reprograms multiple genes in human T cells without many of the challenges & risks associated with traditional gene editing approaches.

A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors go.nature.com/3Jc62gv

Microenvironmental regulation of solid tumour resistance to CAR T cell therapy bit.ly/47bokGU

We're excited to announce the 18 startups selected for #SLAS2026 Innovation AveNEW! Make a plan to visit these exceptional emerging companies located near the SLAS Booth to learn about their life sciences and lab automation advances: slas.org/events-calenda…. #momentumMonday

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Spatial-DMT is now published in @Nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with @zhouwanding lab. Big congrats to Chin @Chin72155594 , Hongxiang @HongxiangFu and team! nature.com/articles/s4158…

@DengYanxiang @Nature @zhouwanding @Chin72155594 @HongxiangFu Congrats! 🎉🎈🍾

Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency cell.com/cancer-cell/fu…

An experimental #BaseEditing strategy for #SickleCellDisease achieves high editing efficiency in hematopoietic stem cells from healthy macaques and persists over time after autologous HSC transplant, according to a recent study. @HPKiem @fredhutch scim.ag/45hCAOx

"For half an hour, I vented everything I had been holding in for months … my supervisor listened patiently, then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." #ScienceWorkingLife scim.ag/47vf7L6