Andrew Octavian Sasmita

Where does Aβ come from in Alzheimer’s disease? 🔍 In this review, we explore non-neuronal Aβ production, functions of APP processing, and how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting. With @ConstanzeDepp link.springer.com/article/10.100…

Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation nature.com/articles/s4159…

How to get bacteria to move from the gut into the brain? —eat a high-fat diet —vagus nerve is the conduit —in the mouse model journals.plos.org/plosbiology/ar…

Optical clearing & time-lapse fluorescent imaging of Live mouse Brain (up to 800 μm of depth)🤯 SeeDB-Live is finally in peer-reviewed print (1.5 yr from Preprint)🥸 An acute olfactory bulb slice(P11) loaded with GCaMP6f (Ca2+ sensor) was imaged with #2PM at a depth of 150 μm during clearing with SeeDB-Live👹 @Shigenori774 @TakeshiImaiLab @naturemethods 2026 nature.com/articles/s4159…

Microglia protein profiles in CSF across Alzheimer’s disease clinical stages idp.nature.com/authorize?resp…

@DuSiling @NeuroCellPress @kipnislab @TheColonnaLab Congratulations!!

🧵Excited to share my thesis work out today in @NeuroCellPress from @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Properties." 🧠🦴 sciencedirect.com/science/articl…

Very excited to share our new work by the one and only ⁦@DuSiling⁩ on blood & skull BM derived cells replacing microglia || Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties - ScienceDirect sciencedirect.com/science/articl…

Multiple molecular mimics in Epstein Barr Nuclear Antigen-1, and the pathogenesis of multiple sclerosis pnas.org/doi/full/10.10…

Genetically altered astrocytes that express chimeric antigen receptors offer a promising immunotherapy system capable of clearing accumulations of amyloid-β in the brains of mice—a hallmark pathological feature of #AlzheimersDisease, according to a new study in Science. 📄: scim.ag/3NjPIfP #SciencePerspective: scim.ag/4rgI1oL

The short-chain fatty acid butyrate prevents gut-brain amyloid-β pathology and neuroinflammation in an Alzheimer mouse model idp.nature.com/authorize?resp…

Using knock-in mouse models of Alzheimer’s disease, Liu et al. show that Aβ-induced loss of parenchymal border macrophages disrupts glymphatic function even before amyloid plaques form. Plaque-reducing immunotherapy fails to restore glymphatic clearance. shorturl.at/zfDg6

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity pnas.org/doi/10.1073/pn…

New @Nature The brains of Super Agers produce more neurons than people some 40 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills nature.com/articles/s4158…

I can personally say that Pokémon really got me into science so this coverage is a pleasant surprise ◓

Selective Cortical Myelination Reflects Axon-Driven Progression of the BCAS1-positive #Oligodendrocyte Lineage. #myelin biorxiv.org/content/10.648…

Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury: Cell cell.com/cell/fulltext/…

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature cell.com/cell/fulltext/…

Thrilled to share that our new paper is now published. It’s been a real privilege to work on this project together with co-first author @don_arafa, under the supervision of David Lyons, and with such an outstanding team in Edinburgh and internationally! science.org/doi/10.1126/sc…

Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage onlinelibrary.wiley.com/doi/full/10.11…

A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain and multiple organs at cellular resolution. Adriano Aguzzi and Fritjof Helmchen teams. biorxiv.org/content/10.110… #DISCO #clearing #3Dimaging #lightsheet #HumanTissue #FFPE #Histology