Adam Tanguay

Happy to share our new publication in GeroScience: "Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging." link.springer.com/article/10.100…

New PRG4 paper on aging! The molecule that never ceases to surprise: Serum PRG4 down with age. Deficiency results in decreased survival in mice and accelerated skeletal aging in M mice. Great work by former PhD student @ATang029 and awesome collaborators. pubmed.ncbi.nlm.nih.gov/40537697/

Thank you to my previous advisor and corresponding author, @tanninschmidt , as well as the co-authors, reviewers, and editors for their contributions.

Happy to share our new publication in GeroScience: "Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging." link.springer.com/article/10.100…

@CraigABrill @Facts_R_Good @JohnStreicher1 Therefore, a lower indirect lowers the total award from 150k to 115k. Indirects are critical for research to happen and covers a huge range of costs. Again, this is a funding cut.

@CraigABrill @Facts_R_Good @JohnStreicher1 No, that's not how it works. The direct portion is the base amount and does not change regardless if the indirect award is 0% or 100%. The indirect is a percentage of the direct award paid on top of it. A 100k direct with a 50% indirect is 50k indirect. 15% is 15k indirect.

We have our answer, as expected. They’ll end every research program if it doesn’t make them money. Anyone thinking they can ride this arson into some kind of reform is gravely mistaken.

@CraigABrill @Facts_R_Good @JohnStreicher1 Indirect costs are not the same as admin costs. Indirect and direct funding cannot legally be spent on the same things. They did not increase research funding, and they did not shuffle the money from indirect to direct. A cut to indirects is a cut to research funding.

@Facts_R_Good @JohnStreicher1 There was no cuts to funding! Only requirement are to cut admin costs currently 26-40% of grant to 15% which if implemented means actually more $ for research

The role of govt in funding research is different from other entities. This is bc govt has a vested interest in the future of the people. Not just immediate, but our children and their children. Research is the long game. Breakthroughs now are built on investments 20+ yrs ago.

“Older people are more susceptible to infectious diseases & less responsive to vaccines,” @RuthMontgomery1 Learn more about why & the research on the effects of aging & age-associated diseases on innate immunity from Dr. Ruth Montgomery. medicine.yale.edu/internal-medic…

@agharrison6 @UConn @Lo_Zanzi @BostonChildrens @harvardmed Congratulations!

Thrilled to announce I successfully defended by PhD @UConn. Huge thanks to my mentor Penghua, committee, family&friends for their help & support! Excited to continue my passion for scientific research and join @Lo_Zanzi team as a postdoc @BostonChildrens @harvardmed this summer!

@matsci_mikayla @MSOE Congratulations Mikayla!

I have accepted an Assistant Professor position in the Mechanical Engineering department at @MSOE for Fall 2024! I am cutting it close with a July PhD defense😅, but I am excited to start a new chapter of my life soon! Thanks to everyone who helped me get to this point!

@AlixDeymier Congratulations!

The Deymier lab is expecting a new member in Aug 2024! This long standing science experiment has finally worked!

We are excited to share our work at @ORSsociety #ORS2024. We have several great collaborative studies with @FirooziSaman @mattbfish @RohanShirwaikar @defratelab @sophkim7 @Coppock_JA @DukeOrtho

The Tang lab crew is getting excited to get to Long Beach for the @ORSsociety #ORS2024 annual meeting. We have lots of exciting science to share - and looking forward to catching up with old friends. Safe travels everyone!

Can’t wait! Come stop by if you’re looking for a post-doc!

#PRG4 #lubricin AlphaLISA from @RevvityLifeSci! We developed it with @LubrisBio #rhPRG4, showed PRG4 down in Sjogrens tears, now great to have a kit made/optimized by Revvity CustomTeams. LLOQ ~5ng/ml, only 5ul of sample. Great for serum, tears, saliva - and we’ll see what else!

New lab paper, congrats to @ATang029 & thanks to coauthors! #PRG4 deficient mice have altered femur mechanical/structural/material properties, and more calvarial osteoclasts. AND, #rhPRG4 inhibits osteoclast-ogenesis & activity in vitro. In vivo is next?! onlinelibrary.wiley.com/doi/10.1002/jo…

@VanessaScanlon Congratulations!

I’m bursting from excitement; it’s been such a great day! Our lab was awarded the R03 we applied for last March! And even better than that, our postdoc was invited to interview with her first choice for residency programs!!! 🎉🤩🍾 #MentorFirst #NewPI #SiSePuede

@AlixDeymier Glad to hear it went well, wishing you a speedy recovery!

Survived my 7th surgery in just over 3 years. All is well! #endometriosis #WomenInSTEM #WomensHealth

@AlixDeymier 7!? Hopefully the last. Good luck!

Just booked my 7th surgery in 2 years. Endo and its complications are a beast! Wish me luck for Nov 7th. #endowarrior #chronicillness

Mark your calendars for Mikayla Moody's presentation at the BMES Annual Meeting @BMESociety on Saturday Oct. 14th. They'll be discussing Bicarbonate supplementation for murine bone, and you won't want to miss it! #LatinXinBME #BMES2023 #HHM