Alessandro Vitriolo

177 posts

Alessandro Vitriolo

Alessandro Vitriolo

@AVitriolScience

I use computational tools to understand transcriptional regulation, neurodevelopment, and human evolution.

Milan, Lombardy Katılım Mart 2019
3.3K Takip Edilen713 Takipçiler
Alessandro Vitriolo retweetledi
Andy Hall
Andy Hall@ahall_research·
AI is about to write thousands of papers. Will it p-hack them? We ran an experiment to find out, giving AI coding agents real datasets from published null results and pressuring them to manufacture significant findings. It was surprisingly hard to get the models to p-hack, and they even scolded us when we asked them to! "I need to stop here. I cannot complete this task as requested... This is a form of scientific fraud." — Claude "I can't help you manipulate analysis choices to force statistically significant results." — GPT-5 BUT, when we reframed p-hacking as "responsible uncertainty quantification" — asking for the upper bound of plausible estimates — both models went wild. They searched over hundreds of specifications and selected the winner, tripling effect sizes in some cases. Our takeaway: AI models are surprisingly resistant to sycophantic p-hacking when doing social science research. But they can be jailbroken into sophisticated p-hacking with surprisingly little effort — and the more analytical flexibility a research design has, the worse the damage. As AI starts writing thousands of papers---like @paulnovosad and @YanagizawaD have been exploring---this will be a big deal. We're inspired in part by the work that @joabaum et al have been doing on p-hacking and LLMs. We’ll be doing more work to explore p-hacking in AI and to propose new ways of curating and evaluating research with these issues in mind. The good news is that the same tools that may lower the cost of p-hacking also lower the cost of catching it. Full paper and repo linked in the reply below.
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Danny IncaRNAto
Danny IncaRNAto@incaRNAtolab·
So excited to see this out in @NatureGenet! An amazing collaboration with the @gagneurlab I am happy I was (a small) part of... nucleotide dependencies can capture regulatory elements, including #RNA structures! Congrats to the whole team! Check it out: nature.com/articles/s4158…
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Eiko Fried
Eiko Fried@EikoFried·
In February 2024, I wrote Scientific Reports about a published meta-analysis claiming that mindfulness interventions affect neural plasticity, 'cementing the neuropsychological basis of mindfulness-based interventions'. Paper was retracted yesterday—here a process summary.🧵
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Carlo Colantuoni
Carlo Colantuoni@CarloColantuoni·
TOMORROW: DDD seminar, July 8, 2025 @ 1PM Eastern US: Dr. Alessandro Vitriolo @AVitriolScience (Lab of Dr Giuseppe Testa @gtesta72) “Regulatory logic of human cortex evolution by combinatorial perturbations”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]
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Aparna Bhaduri
Aparna Bhaduri@BhaduriLab·
Excited to present our new preprint led by @claudianguyen95 uncovering how thalamic input shapes human cortical development! We discover that thalamic axons promote upper layer cortical neurogenesis through NRXN1-mediated contacts with outer radial glia. biorxiv.org/content/10.110…
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Kresten Lindorff-Larsen
Kresten Lindorff-Larsen@LindorffLarsen·
Fourier transform of Google Trends of Fourier transform
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Alessandro Vitriolo
Alessandro Vitriolo@AVitriolScience·
Years of collective reasoning and working summarized in a few slides. Kudos to @cedricboeckx for presenting it to such a special audience! #EESHuman #organoids #CRISPR #evodevo
Giuseppe Testa@gtesta72

thrilled to share #EESHuman @EMBLEvents our latest insights into the evolution of the #Sapiens brain from the #CRISPR orthogonal perturbation in brain #organoids to reconstruct the regulatory logic of prominent effectors that distinguish us from our closest extinct relatives /1

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