Dr. Achille Nicoletti

👉 Some news. I'm closing the Kode Zero chapter. Two years in crypto gaming taught me a lot... but it wasn't what I wanted to build the next decade around. My dream was always to help people with their mental health and wellness - using tech and biofeedback to do it. So this account is pivoting. New focus: tech + wellness Crypto folks, no hard feelings if you unfollow. Wellness/AI/builder folks - welcome. New era starts now ❤️🚀

@bengreenfield Breaks beat bulk. 2021 PLOS One shows sitting interruptions raise HF-HRV more than single training sessions. The metabolic cost isn't volume, it's unbroken time.

Here’s the brutal truth: spending one hour in the gym doesn’t undo eight hours of sitting. Even for people who exercise regularly, prolonged sedentary behavior is still linked to metabolic dysfunction, obesity, type 2 diabetes, and cardiovascular disease, no matter how much you hit the gym. Watch the full breakdown on how to hack your environment for more daily movement: youtu.be/yo8MHAsmJ08?si…

@EricTopol Did they separate timing from duration? Circadian alignment matters more than hours.

Sleep health has substantial impact across the whole body, as nicely summarized in this new paper cell.com/cell-reports-m…

@bengreenfield Hourly movement, even three minutes, resets glucose regulation independent of gym intensity. The continuous stillness is a single metabolic stress or you can't exercise away.

@WHOOP @Cristiano Strain trajectory before the match tells more than recovery days. The readiness metric is sympathetic control under load.

How do the greatest stay ready for the biggest moments? @Cristiano’s recovery data leading into Al-Nassr’s title-clinching match tells the story. 👇

@daveasprey Sleep quality > quantity. Your vagal tone recovery during sleep (HRV) is what drives longevity, not duration.

IMO Sleep is the most important longevity tool, don't play around: open.substack.com/pub/asprey/p/i…

@EricTopol Meta-analyses show 17% lower cancer risk in GLP-1 users (HR 0.83). The mechanism question you flagged (weight loss mediation vs. drug effect) is exactly the bottleneck. Trials need arms with matched weight loss but different GLP-1 exposure to isolate it. That design answers it.

Whether there is a real impact of GLP-1 drugs on cancer is unresolved. If confirmed, it could simply reflect weight loss or, as seen for other conditions (e.g. heart, kidney), weight loss independent effects. We need dedicated trials to resolve this important question. git link wsj.com/health/pharma/…

@davidasinclair Gene expression drifts with age, yes. But autonomic tone is the readout you can reverse.

Aging is a drift away from optimal gene expression

@drmarkhyman You don't lower cortisol, you re-time it. The 7am spike drives immunity and energy. Gratitude helps the rhythm, not suppression. People chasing flat cortisol usually end up exhausted.

I used to roll my eyes at gratitude journals. Then I looked at the data. People who practice gratitude consistently have 23% lower cortisol levels — leading to reduced stress, improved sleep, and better immune function. Lower cortisol means less inflammation.. less inflammation means slower aging.

@jayshetty Lucky without trust is just sustained stress. The body feels the difference.

Don’t marry the person that makes you feel lucky, marry the person that makes you feel safe ❤️

The effect showed up in how anxious people felt, not in heart rate or cortisol. And the strongest trials used therapist-guided listening, not random playlists. Translation: structure beats skill. Intention beats volume. Source: de Witte et al., eClinicalMedicine (Lancet), 2025.

Everyone says "make music to heal." A 2025 Lancet meta-analysis says the opposite. They pooled 51 trials and 3,276 people on music + anxiety: → Medium effect on anxiety (g ≈ 0.4) → No publication bias → Worked in clinics, hospitals & workplaces alike → Session length didn't matter...short worked as well as long The kicker: listening beat playing instruments. You don't have to be musical. You have to be intentional.

@bryan_johnson 11.3% dropout on the top dose. The 28% loss assumes people can tolerate it for 80 weeks. 4mg hitting 19% with fewer dropouts than placebo is the dose that actually works. That's your frontier.

These numbers are shocking. It's like we got a new frontier AI model but for the body. Lilly's phase 3 results for retatrutide: > highest dose lost 28.3% of body weight in 80 wks > 70 lbs ave > 45% lost 30% or more of their body weight > 65% on the top dose no longer clinically obese Retatrutide is more dynamic than semaglutide and tirzepatide because it targets three receptors (GIP, GLP-1, and glucagon), versus one and two, respectively. Side effects, on the highest dose (12mg), were higher for retatrutide than tirzepatide (nausea and GI), with an 11.3% drop out rate. The lowest 4mg dose still delivered 19% loss with fewer dropouts than placebo.

@SahilBloom Your nervous system state filters before your personality does. Same person, dysregulated versus grounded, attracts different people entirely.

Life advice nobody told you: Be unapologetically yourself. When you edit your personality, you attract relationships that need constant maintenance. Something incredible happens when you stop filtering yourself to be liked. Right ones stick. Wrong ones walk. That’s a blessing.

@davidasinclair Static order kills. Longevity requires high-entropy variability within stable rhythms.

Longevity comes from maintaining order in complex systems

🎮 UE5 multiplayer tip: ➡️Use FRepMovement instead of replicating Location/Rotation/Velocity separately. ⭐️It bundles them efficiently with quantization + conditional logic, cutting bandwidth by ~60%. Already built into Character/Pawn #UnrealEngine #gamedev #gamedevs

🎮 UE5 Multiplayer Tip: Use Relevancy & Net Cull Distance Stop replicating every actor to every client. Set NetCullDistanceSquared on your actors (default is 225 million = 15,000 units). Actors beyond this distance won't replicate to clients. #gamedev #UnrealEngine #gamedevs

@Im_VheeJoe Merry Christmas! 🎄

@DevDisruptor Merry Christmas

🎄🧑‍🎄 Merry Christmas to all you cyberpunkers! Enjoy the holidays, and hope everyone has a great 2026!!!

@TheCatalystOG Merry Christmas guys! 🎄

Merry Christmas Everyone! 🎄🎁❄️ Roxy, Scorch, & Pyro - (Xmas 2025)

@TheCatalystOG Dude had it coming 😂

Hope your holiday is going better than Jake Paul's jaw. The Catalyst Effect - No Jaw Jake (ep.90)