Australian Adventure

The 4 biomarkers to meaningfully assess a person's risk of coronary artery disease @rayshafarah @aklfahed @pnatarajanmd @JACCJournals @uk_biobank sciencedirect.com/science/articl…

SIRT6 Regulates Protein Synthesis and Folding Through Nucleolar Remodeling "Our data suggest that SIRT6 deficiency results in proteostasis loss through nucleolar dysfunction." onlinelibrary.wiley.com/doi/10.1111/ac…

A ketogenic diet may improve brain function in some — but in others, it can impair memory and cognition. neurology.org/doi/10.1212/WN… #ketodiet #memoryloss #diet

Check out the latest from our Citation Classics series.

Not all impactful science is obvious at the start. Some begins as risky, collaborative experiments. This is one of those stories 👇 citationclassics.com/stories/from-c… #INPST

🏆 We have a winner! Announcing the Highly Cited Paper Award 2025 in Exploration of Digital Health Technology (EDHT). explorationpub.com/Journals/edht/… 👏 Congratulations to the authors! #ExplorDHT #DigitalHealth #OpenAccess #HighlyCited

🔎 Chemical biology tools reveal which microbes are truly working behind the scenes 🔗 inpst.net/innovative-che… 🌐 #INPST #Biotech #CRBIOTECH

@fssaiindia @Amul_Coop @Verka_Coop #milk #pasteurisation

Inulin, a prebiotic fibre, modulates the gut microbiome: Effect of Inulin on Pain Sensitivity in People with Osteoarthritis mdpi.com/2072-6643/18/5… Inulin has an effect on pain perception as it acts as a prebiotic, meaning it feeds beneficial gut bacteria dailymail.co.uk/health/article…

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects—A Review ▶️ Ashwagandha root powder & extracts have long been used in Ayurvedic medicine to improve sleep & anxiety. Recent scientific investigations into its efficacy have shown promise for relief from anxiety, insomnia & stress & for improving the immune system. ▶️ In general, it should be noted that side effects with ashwagandha are rare. Indeed, the levels reported so far in clinical trials are comparable to what would be seen with a placebo. A few cases indicating liver injury have been reported during ashwagandha treatment, even when the dose is <600 mg daily. Symptoms like jaundice, pruritus, elevated liver enzymes and the elevation of bilirubin normalized after withdrawal of treatment in all the cases except one, who had been treated earlier for a cancer and had received glucocorticoids. mdpi.com/2072-6643/18/5… @HealthyFellow @tatiann69922625 Ashwagandha plant, including the root. As is the case for other plants of the Solanacea family, the roots of the ashwagandha plant are not poisonous.

Enhanced Bioavailability & Health Benefits of Blueberry Anthocyanins: An Updated Rev on Mechanisms & Approaches ▶️ This review consolidates recent progress in understanding the structural variety, biological roles, & key factors affecting the stability & bioavailability of blueberries, emphasizing their significance as strategic assets for the development of functional foods & nutraceuticals. A significant obstacle to the effectiveness of blueberry anthocyanins is their inherent chemical instability and low bioavailability. ▶️ Blueberries are highly valued for their nutritional content, primarily due to their high anthocyanin content, which is the principal bioactive compound contributing to their health-enhancing properties. ▶️ Extensive research has established that blueberry anthocyanins exhibit significant antioxidant activity & confer various health benefits, including anti-cardiovascular, anti-diabetic, anti-inflammatory, and anticancer effects, as well as enhancements in cognitive function & visual acuity. mdpi.com/1420-3049/31/5…

Role of flavonoids as anti-inflammatory agents in inflammatory diseases ▶️ Flavonoids, a diverse variety of plant-derived polyphenols, have shown promising anti-inflammatory effects. ▶️ Flavonoids modulate inflammation through several mechanisms, including antioxidant effects & enzyme inhibition. ▶️ Different classes of flavonoids, such as catechins (e.g., epigallocatechin gallate), flavonols (e.g., quercetin), flavones (e.g., baicalin), & isoflavones (e.g., genistein), act on inflammatory mediators like AP-1, TNF-α, NF-κB, IL-1β, & COX2 to reduce inflammation. sciencedirect.com/science/articl…

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature ▶️ Blood factors transfer the benefits of exercise to the aged brain independent of physical activity. ▶️ Liver-derived exercise factor (exerkine) glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1), a GPI-degrading enzyme, reverses aging- & Alzheimer’s-related memory loss by targeting the brain vasculature. cell.com/cell/fulltext/…

Agrin at the crossroads of aging: A pleiotropic regulator in age-related diseases sciencedirect.com/science/articl…

Healthcare is going digital 📲🧠 AI, wearables, telemedicine saved care during COVID-19 — but ethics, equity & privacy still lag. 💬 Progress or risk? #DigitalHealth #HealthTech #AIinHealthcare 🔗pmc.ncbi.nlm.nih.gov/articles/PMC12…

Gut microbiota-derived metabolites (GMDMs) as immune modulators in aging and age-related chronic inflammatory diseases ▶️GMDMs orchestrate gut-immune circuits across multiple organs. ▶️Age-related dysbiosis alters GMDM pools, driving systemic inflammation and age-related diseases (ARDs). ▶️GMDMs can act as biomarkers of organ-specific aging states. ▶️Changes in GMDMs may define personalized aging trajectories. ▶️Artificial intelligence powered multi-omic analysis can identify therapeutic strategies for precision geromedicine. sciencedirect.com/science/articl… GMDM classes, SCFAs, tryptophan-indole derivatives, bile acids, pro-inflammatory uremic/pro-atherogenic metabolites (TMA/TMAO, IS, PCS), & additional moieties (BCFAs, organic acids, vitamins, BCAA/AAA metabolites) reprogram immunometabolic circuits across liver, adipose, muscle, brain, lung, heart, pancreas, kidney, retina, & joints, thereby shaping organ-specific ARDs. Each organ shows cell-type-specific effects, yet dysbiotic GMDM profiles drive convergent pathology (barrier loss, chronic inflammation, fibrosis) & cross-organ propagation (e.g., renal-muscular & renal–cardiovascular axes). Collectively, this metabolite network synchronizes systemic aging trajectories & the progression of diverse ARDs.

Unusual, but true: lung tumours talk to the brain 🧠 They hijack nerve circuits to silence anti-tumour immunity—and breaking this loop slows cancer growth. Are nerves the next hidden target in oncology? 🔗nature.com/articles/s4158… 🌐#CancerResearch #Oncology

🧵 [1/6] Unlocking bacteria’s full biotech potential! Discover strategies to boost recombinant protein secretion: 🔗 inpst.net/advancing-reco… 🌐 #Biotechnology #SyntheticBiology #CRBIOTECH @DrSeeboth @DrSharadVats1 @HealthyFellow @MettaHealthUK @DrRPalmquist @ShraboniGhosal

Aging reshapes the adaptive immune system from healer to saboteur nature.com/articles/s4358…

@Math_files ▶️ "The first principle is that you must not fool yourself—and you are the easiest person to fool." – Richard Feynman, physicist 🌐 #Science #DHPSP #Mathematics