Alex C.Y. Chen

Online now: Distinct tissue niches contribute to prostate tissue-resident memory CD8+ T cell differentiation and heterogeneity dlvr.it/TRq8ms

uPAR CAR T cells eradicate primary and metastatic solid tumors with minimal myelodepletion by targeting both tumor cells and the stroma in preclinical models @CellCellPress @LoweLabMSKCC @Columbia cell.com/cell/fulltext/…

For decades, we taught a simple rule: MHC I → CD8 T cells, MHC II → CD4 T cells. Turns out, that’s incomplete. MHC I doesn’t just help CD8s “see” cells — it also protects cells from CD4 T cell–driven killing.nature.com/articles/s4159…

New Online! Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target dlvr.it/TRknlS

A reciprocal KLF2-KLF3 transcriptional circuit that controls cellular localization reveals that enforcing T cell migration limits terminal exhaustion and promotes effector-like differentiation @ImmunityCP @CuiWeiguo @NorthwesternU cell.com/immunity/fullt…

Age-related NF-κB activation in fibroblasts remodels the lung resident immune system and promotes the emergence of pro-inflammatory Gzmk+ T cells @ImmunityCP @UCSF cell.com/immunity/fullt…

@biorxivpreprint A genome-wide CRISPR Screening identifies targets that drive Tolerogenic Dendritic Cells biorxiv.org/content/10.648… @abbvie

Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion @Nature @EmoryUniversity @rafiahmed_lab nature.com/articles/s4158…

Review @NatureRevCancer @parkerlabPMCC Striking the right balance with type I interferon signalling in cancer nature.com/articles/s4156…

KLF3 opposes KLF2 in differentiation of some memory T cell subsets, while KLF2 and KLF3 cooperate for differentiation of others @PNASNews @Jamequistlab @chwpeng @cfi_umn pnas.org/doi/10.1073/pn…

Excited to share- Building on our work defining TRMacs heterogeneity, we show that distinct chemokine+ IM subsets and recruited TAM niches shape pro- and anti-tumor immunity within to the TME, while Ag+ moDCs trafficking to LNs dampen DC-based neoAg vac nature.com/articles/s4159…

Macrophage lineage and spatial compartmentalization govern tumor immunity @NatImmunol @claudjak @soubhik1992 @RawatKSM @XinLi0419 @AishwaryaDighal @dartmouth nature.com/articles/s4159…

@biorxivpreprint A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging biorxiv.org/content/10.648…

Weaning drives microbiome-mediated epigenetic regulation to shape immune memory in mice @NatureMicrobiol @shen_lanlan @BCMFromtheLabs nature.com/articles/s4156…

DGAT1 mediates sex-specific CD8+ T cell antitumour responses dlvr.it/TRcNs3

@biorxivpreprint Aging-associated endo-lysosomal dysfunction drives inflammaging and neurodegeneration through the STING-IFN-I axis biorxiv.org/content/10.648…

Hyperinnervation inhibits organ-level regeneration in mammalian skin @CellCellPress @Harvard cell.com/cell/fulltext/…

Nature research paper: Proteasome-guided haem signalling axis contributes to T cell exhaustion go.nature.com/474nw7t

@biorxivpreprint Memory NK cell generation to cytomegalovirus infection is regulated by age and T cell immunity @DonnaFarber3 @Columbia biorxiv.org/content/10.648…

@biorxivpreprint Diverse lung challenges elicit a conserved monocyte-to-macrophage differentiation blueprint @CIliakis @bainlab @TheCrick @EdinburghUni 🏴󠁧󠁢󠁳󠁣󠁴󠁿🇬🇧 biorxiv.org/content/10.648…