Alyson Fiorillo, PhD

Another scientist whose work initially didn't get the recognition that it deserved - Victor Ambros was denied tenure at Harvard, even after publishing the seminal work that resulted in him receiving the Nobel Prize today!

The Splice Index as a prognostic biomarker of strength and function in myotonic dystrophy type 1 biorxiv.org/content/10.110…

@YountLabOSU Corel Draw!

What software is everyone using for generating high res publication figures? We recently made the switch from Powerpoint to Illustrator, but the university is canceling our Adobe subscription and a monthly fee for everyone in the lab isn't gonna work. 🥲😡😩

The follow up work related to this manuscript was recently funded by @MDAorg and we are looking for talented post-docs and lab staff to join our team! You can email me at Alyson.Fiorillo@vcuhealth.org. (3/3)

Shout out to @TheHeierLab for another great collaboration. I also wanted to mention that my lab (@FiorilloLab) recently moved to @VCU to join the Center for Inherited Muscle Research led by @nickjohnson30. I am incredibly excited to be a part of this amazing group! (2/3)

Happy to share our latest article: Deletion of miR-146a enhances therapeutic protein restoration in model of dystrophin exon skipping: Molecular Therapy - Nucleic Acids cell.com/molecular-ther…. Congrats to first author and talented post-doc @nikkimmccormack! #DMD #microRNA (1/3)

@lvolpic We just got a quote from Leica to fix a cryostat that was no longer cooling. 25K.

Leica wants us to pay $10,000 to get our sliding microtome SM2010R serviced. Is there another company that can do it? Can I buy a cheaper microtome?

Our new paper is published! Learning more about how steroids work in #Duchenne. Congrats to Trinitee on her first 1st author paper! @DMM_Journal has a nice interview with her, link to follow. @MDAorg @ParentProjectMD @FiorilloLab @MYOTWlTTER #DMD journals.biologists.com/dmm/article-lo…

#MDA celebrates the @US_FDA approval of AGAMREE® (vamorolone) to treat children and adolescents living with #Duchenne #MuscularDystrophy (#DMD). Learn more about this novel therapy, supported in part by MDA Venture Philanthropy: mda.org/press-releases…

Positive news for boys with #Becker #MuscularDystrophy: Vamorolone improves disease progression with fewer side effects than current treatments. Read more from @TheHeierLab, @AlysonAFiorillo & the Center for Genetic Medicine Research. ⬇️ …ovationdistrict.childrensnational.org/new-becker-mus…

Congrats to @jyoti_k_jaiswal #JamesNovak & colleagues for their interesting new #CellDeathDiscovery paper: Altered muscle niche contributes to myogenic deficit in the D2-mdx model of severe DMD. tinyurl.com/y3za3cd2

Great team effort led by a very talented post-doc @nikkimmccormack. We find 1) vamorolone shows efficacy in our bmx mouse and 2) demonstrate that vamorolone reduces dystrophin-targeting miRNAs and increases dystrophin in skeletal muscle and heart!

Our new paper is out! Vamorolone improves disease and increases dystrophin in our Becker muscular dystrophy model. Now in clinical trials (NCT05166109) #MuscularDystrophy #Becker #dystrophin @FiorilloLab @MDAorg @ParentProjectMD @nih_nhlbi @iScience_CP #secsectitle0070" target="_blank" rel="nofollow noopener">cell.com/iscience/fullt…

Our co-founder Alex Johnson and her son Jack appeared on @BBCBreakfast this morning to talk about Jack's journey down to London for the King's Coronation! 👑 @alljoinjack

For male academics (who are 4x more likely to have a partner at home doing domestic care), the start of the COVID pandemic was a publishing boon. Of the 45 most prolific medical journal authors (60+ papers) during the 1st 18 months, just 5 were women. bmj.com/content/381/bm…

@theFourier2k @MatthiasLambert @HogarthMarshall @MDAorg And @James Novak - we need to get him on muscletwitter!

Great to see @MatthiasLambert @AlysonAFiorillo @HogarthMarshall and other next generation muscle disease research leaders feature in Genetic mechanisms session at #MDA2023 @MDAorg

Yass! Operation warp speed for rare diseases proposed by Peter Marks (CBER, FDA) #mda2023 @NIHFunding @NIHDirector take note rare disease community are sick of being patient .. your inefficient funding cycles and processes don’t cut it in the information age!

New Research: Editorial: Genome and transcriptome editing to understand and treat neuromuscular diseases frontiersin.org/articles/10.33… #GenomeEditing #CRISPR

It was a pleasure working with co-editors @RikaMaruyama_E, @AlysonAFiorillo, @MacGyver0282, and Dongsheng Duan. Looking forward to more breakthroughs in the field! #ScienceAdvances #NeuroMuscularDiseases