Salman Banani

53 posts

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Salman Banani

Salman Banani

@BananiSF

Assistant Professor @UChicago | Previously @WhiteheadInst @BrighamWomens @UTSWNews. Condensate biology and disease.

Chicago, IL Katılım Ocak 2015
1K Takip Edilen215 Takipçiler
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Raghu Chivukula, MD PhD 🫁🧬🧠
Raghu Chivukula, MD PhD 🫁🧬🧠@chivukula_raghu·
Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…
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Ben Sabari
Ben Sabari@bsabari·
I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. cell.com/cell/fulltext/….
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Whitehead Institute
Whitehead Institute@WhiteheadInst·
Many chronic diseases have a common denominator that could be driving their dysfunction: reduced protein mobility, which in turn reduces protein function. A new paper from @youngricka's lab describes this pervasive mobility defect: wi.mit.edu/news/cellular-…
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Ben Sabari
Ben Sabari@bsabari·
I am excited to share our review, published online today @NatRevMCB. Pilong Li, Gaofeng Pei, @Heankel_, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1). nature.com/articles/s4158…
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Pradeep Natarajan
Pradeep Natarajan@npradeep96·
Pre-print alert! With experimental collaborators at the Young lab (MIT), we investigate how (i)active rRNA transcription maintains the size, spacing, and number of nucleolar fibrillar centers, (ii) the consequence of this arrangement on rRNA processing. biorxiv.org/content/10.110…
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UT Southwestern Medical Center
UT Southwestern Medical Center@UTSWMedCenter·
#UTSW biochemist Zhijian "James" Chen, Ph.D., wins the Albert Lasker Basic Medical Research Award, sometimes called “America’s Nobel,” for his discovery of the cGAS enzyme, which senses invading pathogens and triggers immune response. bit.ly/3MQjHIr @LaskerFDN
UT Southwestern Medical Center tweet mediaUT Southwestern Medical Center tweet media
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Prashant Bhat
Prashant Bhat@_prashantbhat·
A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread! nature.com/articles/s4158…
Mitch Guttman@mitchguttman

What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez

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Ben Sabari
Ben Sabari@bsabari·
Excited to share a new collaborative paper from my lab and the @transactivators lab where we find that condensate formation of the cell type specific coactivator Myocardin drives gene activation during cardiovascular differentiation. science.org/doi/10.1126/sc…
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Whitehead Institute
Whitehead Institute@WhiteheadInst·
An 11th grade student from Westford MA asks: what are condensates? Thank you postdoc Alessandra Dall'Agnese for answering their question! Our latest #AskaScientist video is published on BioNook, Whitehead Institute's online biology resource: wi.mit.edu/bionook/ask-a-…
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Keşfet

@RyanLCollins13 @VanAllenLab @DanaFarber @ScienceMagazine @BiophysJ @HarvardCCB @ShakhnovichLab @youngricka