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JCBeltra@BeltraJc·13 Ara

Our latest story is out in @CellPressImmunity today!! We show that Stat5 opposes Tox and rewires exhausted CD8s towards more durably protective effector-like states. Shout out to my co-authors, @parkerici and @EJohnWherry Key take-home messages in the 🧵⬇️ cell.com/immunity/ppt/S…

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JCBeltra@BeltraJc·5 Eyl

🚀 Thrilled to share that our group has been awarded an ERC Starting Grant! 🎉💪 Many thanks to the @ERC_Research, the @DepBiomedicine and the entire team for their dedication. Stay tuned for exciting new science on T cell exhaustion 🔬💡

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JCBeltra retweetledi

Department of Biomedicine@DepBiomedicine·4 Eyl

Big news 🎉: Four DBM researchers win ERC Starting Grants! Their projects span cancer immunotherapy, immune ageing, breast cancer metastasis & neuro-oncology. Congrats Jean-Christophe Beltra, Mariana Borsa @nanaborsa, Magdalena Sznurkowska @m_sznurkowska & Tobias Weiss! 🔗biomedizin.unibas.ch/en/communicati… @ERC_Research @DepBiomedicine #ERCStG #ResearchExcellence #Biomedicine

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JCBeltra@BeltraJc·15 Oca

@HakeemLab_Emory @UniBasel_en Had a great time with a good friend! Thanks for the visit, @M_S_Hakeem , and for the insightful presentation. Excited to see the amazing stories coming out of the @HakeemLab_Emory soon!

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HakeemLab@HakeemLab_Emory·15 Oca

Had a blast catching up with postdoc sci partner @BeltraJc! Stay tuned for great science from BeltraLab! Thanks to the amazing @UniBasel_en Immunology community for insightful discussions on @HakeemLab_Emory projects!! Visiting beautiful Switzerland was a plus!

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JCBeltra@BeltraJc·4 Eki

@HakeemLab_Emory @EmoryPathology @DecaluweHelene @UMontreal @EmoryUniversity Awesome!!! Wish I’d been there!!

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HakeemLab@HakeemLab_Emory·4 Eki

Great @EmoryPathology Seminar by @DecaluweHelene today on manipulating IL-2/IL-15 pathways in Tex for immunotherapy! Awesome to have one of @UMontreal Superstars visiting @EmoryUniversity ... and one name (@BeltraJc) kept getting mentioned all the time!!!😃

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JCBeltra@BeltraJc·6 Eyl

Had an amazing time at the C3T workshop @karolinskainst 🇸🇪Exciting science pushing ACT for cancer- terrific talks including by A. Schietinger @SchietingerLab on immune triads! Thanks for the kind invite @CGerlach_lab & Yenan Bryceson!

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JCBeltra@BeltraJc·2 Eyl

Ready for 3 days of exciting science at #ECI2024 in the lovely city of Dublin 🇮🇪🍀 Can’t wait to see new developments in Cancer Immunotherapy!!

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JCBeltra@BeltraJc·21 Haz

@divijmathew Congrats Divij!! So cool its finally out!

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Divij@divijmathew·21 Haz

extremely excited to share our new story on the impact of JAK inhibition on responses to immune checkpoint blockade in lung cancer patients! 🧬🧑‍🔬 thread on our main findings 🧵 1/n science.org/doi/10.1126/sc…

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JCBeltra@BeltraJc·30 Nis

🚨 COME JOIN OUR TEAM!!! My lab is looking for a talented postdoc to join our ranks at the @DepBiomedicine of the @UniBasel_en 🇨🇭! If you are a T-cell enthusiast fascinated by exhaustion and cancer immunotherapy - Apply here 👇 👇 👇 jobs.unibas.ch/offene-stellen…

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JCBeltra@BeltraJc·10 Nis

@EvanWeberPhD @Nature @alexdoan96 @kpmueller1 @andy_yhchen Fantastic! Congrats Evan!!👏

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Evan Weber@EvanWeberPhD·10 Nis

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs? We answer this in our lab’s first paper in @Nature led by @alexdoan96 @kpmueller1 @andy_yhchen. 1/ nature.com/articles/s4158…

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JCBeltra@BeltraJc·12 Oca

@C_Alanio @institut_curie @NatureCancer @StephenBagleyMD @PennMedicine @parkerici Congrats Cecile !!! 💪💪💪

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JCBeltra@BeltraJc·8 Oca

@MFMich1 @JExpMed Woot woot 🤘🤘Congrats @MFMich1

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MF Michieletto@MFMich1·8 Oca

1/ Today is a big day: I'm proud to announce that our latest study on the role of Eomes in CD4 T cell biology has been published today in @JExpMed. (rupress.org/jem/article/22…).

Journal of Experimental Medicine@JExpMed

.@EmelineJ66, @asdejean et al. @InfinityTLS reveal a new mechanism whereby the transcription factor Eomes promotes CD4+ T cell accumulation in inflamed tissue thru. increased mitochondrial functions & resistance to cell death hubs.la/Q02fC_Xx0 @MFMich1 @jeansarry @lyacts

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JCBeltra@BeltraJc·3 Oca

@CD_AACR @EJohnWherry @WherryLab @parkerici Thank you @CD_AACR for highlighting our work.!

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Cancer Discovery@CD_AACR·3 Oca

Read Cancer Discovery's #ResearchWatch: IL-2-STAT5 Activity Antagonizes TOX and Reverses CD8+ #TCell Exhaustion, summarizing the work of @BeltraJc, @EJohnWherry et al. bit.ly/48EDmnz @WherryLab @parkerici

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JCBeltra@BeltraJc·18 Ara

Very nice meeting for cytokine enthusiasts! Can't wait for the 2024 session in Seoul!

ICIS 🦋 @cytokinesociety.bsky.social@CytokineSociety

Save-the-Dates Cytokines 2024: 12th Annual Meeting of the ICIS Joint with Korean Association of Immunologists International Meeting 2024, October 20 to 23, 2024 at COEX, Seoul, Korea. Please R/T cytokinesociety.org/save-the-date-… via @httpstwittercomCytokineSociety

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JCBeltra@BeltraJc·13 Ara

@MFMich1 Thanks @MFMich1 !!! 🍻

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MF Michieletto@MFMich1·13 Ara

Terrific study, congrats JC !

JCBeltra@BeltraJc

Our latest story is out in @CellPressImmunity today!! We show that Stat5 opposes Tox and rewires exhausted CD8s towards more durably protective effector-like states. Shout out to my co-authors, @parkerici and @EJohnWherry Key take-home messages in the 🧵⬇️ cell.com/immunity/ppt/S…

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JCBeltra@BeltraJc·13 Ara

@PCHo_Lab @EJohnWherry Thank you!!

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HoLab@PCHo_Lab·13 Ara

Waiting for so long! This is a very cool story. Congrats to @BeltraJc and @EJohnWherry !

JCBeltra@BeltraJc

Our latest story is out in @CellPressImmunity today!! We show that Stat5 opposes Tox and rewires exhausted CD8s towards more durably protective effector-like states. Shout out to my co-authors, @parkerici and @EJohnWherry Key take-home messages in the 🧵⬇️ cell.com/immunity/ppt/S…

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JCBeltra@BeltraJc·13 Ara

@golnaz_v Thank you Golnaz!!

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Golnaz Vahedi@golnaz_v·13 Ara

@BeltraJc @parkerici @EJohnWherry Excellent news. Congrats JC and team.

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JCBeltra@BeltraJc·13 Ara

Our latest story is out in @CellPressImmunity today!! We show that Stat5 opposes Tox and rewires exhausted CD8s towards more durably protective effector-like states. Shout out to my co-authors, @parkerici and @EJohnWherry Key take-home messages in the 🧵⬇️ cell.com/immunity/ppt/S…

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JCBeltra@BeltraJc·13 Ara

Temporal increase of Stat5 activity in TEX progenitors removes some epigenetic “scars” of exhaustion and restores polyfunctionality.

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JCBeltra@BeltraJc·13 Ara

Temporal increase of Stat5 activity in TEX amplifies the “effector-like” intermediate subset of TEX and synergizes with PD-L1 blockade in the process.

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JCBeltra@BeltraJc·13 Ara

- Enforcing Stat5 activity opposes Tox expression and redirects CD8 T cells away from exhaustion towards a transcriptionally and epigenetically distinct effector/NK-like state with features of increased durability and superior anti-tumor potential.

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