Benjamin K.J. Tan

1) In our meta-analysis with parametric cure modelling, involving 3,699 participants in 18 studies worldwide, an estimated 15 mil and 12 mil adults may have persistent smell👃and taste👅dysfunction after COVID-19. Here's a quick summary and guide on what to do if you're affected:

In meta-analysis, moderate-certainty that 47% of wet AMD pts had retinal fluid after 2y of anti-VEGF treatment. Cure-models predict that up to 18% of patients may never achieve fluid resolution @dominicyap_ @BenjaminKJTan @snec_seri @NUSMedicine @mysgh ow.ly/cCFo50USqRb

Dual sensory impairment: Global prevalence, future projections, and its association with cognitive decline #dualsensoryimpairment alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

In a real-world meta-analysis, N=1.6 mil. Isotretinoin users don't have higher risks of suicide or psychiatric disorders, compared to non-users. They have lower risk of attempted suicide at 2-5 years post-treatment. @NicoleTanKW @BenjaminKJTan ja.ma/411GOWP

People who used devices for #HearingLoss saw a reduced risk of long-term cognitive decline and an improvement in short-term general cognition: bit.ly/3D0l17f #dementia #neurotwitter @BenjaminKJTan @jsgolub @BarrowNeuro @PittSHRS @AANMember

@NicholasRowanMD @JAMANeuro @jsgolub @agingdoc1 @davidasinclair Thanks for your interest in our study! Another great reason for people to get their hearing checked and treated! @brianyeosy @Harris_Song_JJ @emmamstoh @reshmaamerchant

now this is a COOL study! Lower cognitive decline & dementia in hearing aids and cochlear implant users. ja.ma/3W4AoT2 @JAMANeuro @jsgolub great editorial to boot! @agingdoc1 @davidasinclair you should check this out.

The controversy continues. We just published in @JAMAOnc an analysis showing minimum benefit of immunotherapy for low PD-L1 expressing esophageal tumors jamanetwork.com/journals/jamao…, @FengWan25720657 shows the opposite ascopubs.org/doi/10.1200/JC…. are we none the wiser? @FilippoPietran4

Efficacy of ICI in ESCC patients with low PDL1 expression: Our pooled analysis shows there may not be OS benefit in TPS<1% pts. Harmonised biomarkers needed for better pt selection @FilippoPietran4 @sundar__raghav @NickyWongZH @josephjzhao ja.ma/3UIM5xB @JAMAOnc

Another important paper on ICI efficacy in low PDL1 ESCC utilizing KMSubtraction - congrats @dominicyap_ 🎉🎉 @JAMAOnc

Very interesting: Hearing aids and cochlear implants seem to reduce cognitive decline and dementia in older adults with hearing loss. (N = 137,484) doi.org/10.1001/jamane…

Thank you also to @jsgolub for the valuable commentary! With the recent creation of over-the-counter hearing aids led by @DrFrankRLin, access to hearing loss treatment will continue to improve.

@NEJM The same magnitude of benefit was seen for patients who started with normal cognition and those with mild cognitive impairment. So it's never too late to treat hearing loss—the benefits accrue over time. Many thanks to @brianyeosy @Harris_Song_JJ @reshmaamerchant and all authors!

#lecanemab in @NEJM has gained fame last week for #Alzheimer's disease. But you could get a similar 20% benefit by treating your #hearingloss with #hearingaids, without the 20% risk of brain swelling/micro-bleeds. Our analysis of 31 studies with >130k patients over 2-25 yrs below

Our commentary @JAMANeuro on a meta-analysis by Yeo et al of hearing aids & cochlear implants for prevention of dementia is now published. Congrats to co-authors @MichaelWDenham and Rachel Weitzman @ColumbiaOto. 🦻🧠 jamanetwork.com/journals/jaman…

Great meta-analysis. Thank you for allowing me to write a Commentary @JAMANeuro

In this meta-analysis, #HearingAid and #CochlearImplant use was associated with a decreased risk of subsequent #CognitiveDecline. @BenjaminKJTan @brianyeosy @Harris_Song_JJ @reshmaamerchant ja.ma/3FrsmOv

Our recently published meta-analysis found that the use of acid suppressants in early life increases the risk of allergic disorders in childhood. We urge judicious use of acid suppressants, only according to established guidelines and indications, to mitigate this risk.

📢🔥SRMA: Childhood acid-suppressant use was associated with a 🔼 hazards incident of Asthma 44% AD 12% AR 40% Risk may be more significant with a younger age at first exposure, particularly the first 2⃣ years of life. #relatedArticles" target="_blank" rel="nofollow noopener">jaci-inpractice.org/article/S2213-… #GITwitter #paed #allergy

In Press! #Childhood #acid #suppressants may increase #allergy #risk -a systematic review and meta-analysis buff.ly/3Delsew

No nurses, now she’s finishing off years of effort in reducing antibiotic overuse by handing them out like sweets #nhs

It’s sad that @HelenRSalisbury needed to write this in the @bmj_latest, but she’s right, it has to be repeated. On fining people for missed appointments. “This is a way to bake in inequalities: punching down, rather than levelling up” Link if preferred: bmj.com/content/378/bm…