Captain G.@ero
225 posts

Captain G.@ero
@CaptainGaero
Former Airline Captain Lost career & more to Lyme disease. Fighting my way out, slowly winning toughest game ever.

Days after bee venom was found to kill cancer…


NEW: CDC official says the U.S. is actively searching for therapies for the new Ebola strain.


















$IBRX Expanding into infectious disease and sepsis, which have a much larger TAM than cancer, involves combining Anktiva (IL-15) with T-797 (an invariant natural killer T cell), which could be produced on the NANT Leonardo platform. The company’s move into the infectious disease space will begin with a Phase 3 trial (NCT07492875) for Severe Community-Acquired Pneumonia, alongside a Phase 2 trial (NCT07492888) for the same condition, with or without Sepsis/ARDS. More details about the sepsis market and the opportunities offered by the NANT Leonardo platform are available in my March post. huggenberg.substack.com/p/the-leonardo…



The more we learn about the power of IL-15 and the literature that exists decades ago (since 2010!) and never exploited is so exciting. Sepsis is responsible for over 200,000 deaths annually in the United States. We are planning a trial in community acquired pneumonia and sepsis. What is remarkable is the finding that Pseudomonas, a bacterial infection induces apoptosis (cell death) of NK cells, dendritic cells and CD8+ T cells contributing to mortality. More remarkable is the finding that IL-15 blocks this killing of these protective NK and CD8 T cells and improves survival. In this paper the final conclusion: "IL-15 prevents two immunopathologic hallmarks of sepsis, namely, apoptosis and immunosuppression, and improves survival in two different models of sepsis. IL-15 represents a potentially novel therapy of this highly lethal disorder." The more we learn, the more wondrous is this IL-15 cytokine molecule in our body! Our Sepsis Trial: ResQ218B-CAP clinicaltrials.gov/study/NCT07492… pubmed.ncbi.nlm.nih.gov/20026737/




Dr. Amy Proal on the Tick Bootcamp podcast last week: “If you’re a pathogen and you’re going to infect someone, and persist in their body, the blood is not a smart place to be... A lot of pathogens over time will hide in a person’s tissue… Where they’re somewhat able to evade immune recognition.”













