Carl Mitchell

Online Now! Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells dlvr.it/T6xPmG #stemcells

@DPoscablo @CellCellPress @Forsberg_Lab Congrats!!!

Beyond proud to share my thesis work, out today in @CellCellPress! My deepest gratitude to my amazing co-authors, those who come before me whose beautiful work this is built upon, and my extraordinary advisor, Camilla Forsberg. @Forsberg_Lab cell.com/cell/fulltext/…

When I started this project, my baby was a baby and most people hadn’t heard of an N95. Today, I have a second grader, the world is a different place, and this labor of love is finally out in the world!! sciencedirect.com/science/articl…

Help save the Dog Aging Project. Despite being one of the most influential, productive and impactful NIH supported projects over the past 5 years, the National Institute on Aging has inexplicably chosen to withdraw support for the Dog Aging Project. For now, I’m won't get into the details of the process or my personal feelings about it, as the important thing is to ensure the Dog Aging Project doesn’t end. If you believe that the Dog Aging Project has value and should continue, I have three requests of you: (1) Please consider signing the petition to the NIH Director here: actionnetwork.org/petitions/supp… (2) Please consider sending an email to your elected representatives here: actionnetwork.org/letters/suppor… (3) Please share this message with your network as broadly as you can Thank you!!!

Excited, relieved, and yes, proud to put this work out into the world. Short 🧵 below…

Kang @YKang_Lab, Paik @hyojungpaik, Passegué et al. identify a novel secretory subset of myeloid-biased multipotent progenitors, MPP3, that serves an essential regulatory function to amplify #myeloid cell production in stress and disease conditions. bit.ly/3n8Cllu

For you deliberate cold exposure skeptics and devotees alike, this is an interesting new study on 1X per week cold immersion & 5X per week cold showers on fat loss and various mood related parameters. Still, avoid it after hypertrophy training. pubmed.ncbi.nlm.nih.gov/36599485/

Layperson write-up of our recent study on the effects of localized inflammation on blood production

📢Latest @NatureCellBio:"Stromal niche #inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic #ageing" by @Carl_A_Mitchell, Passegue and Co. from @CSCIColumbia 👉Read N&Vs by Ambrosi and Chan: rdcu.be/c3FmO nature.com/articles/s4155…

@amieramadani @NatureCellBio @CSCIColumbia Thanks Amiera!!

@Carl_A_Mitchell @NatureCellBio @CSCIColumbia Congrats 👏🏾

All the evidence from human studies seems to indicate that TRE is no better than other forms of caloric restriction for weight control or other metabolic benefits (insulin resensitization), and may actually be worse in some respects

Learned today that a nicotinamide riboside supplement maker (not Chromadex) is targeting authors of a recent paper suggesting possible increased cancer risk from NR. This is bad news for science 1/6

@DrJaneXu @TheDoctorIsVin Congrats!!!

Excited to have the opportunity to present my work at #ASH22. Very grateful to receive the achievement award and all the support from the amazing @TheDoctorIsVin

@Hemasphere_EHA @EHA_Hematology Great meeting you guys and hope to see you again at the next one!

@Carl_A_Mitchell @EHA_Hematology It's been so great having you three here! Don't be strangers, and meantime, keep up the excellent work. #LabDreamTeam

Simply overjoyed to be in Palermo for #ehaRecon22 presenting our work on hematopoietic stem cell aging @EHA_Hematology

In a new paper in Nature, scientists looked at candidates for reversing dysregulated gene expression in Alzheimer's disease and guess what outperformed all tested drugs? Exercise. Why isn't this front page news?

Rather than saying I study “aging”, I think I’ll start saying I study “system integrity” of the organism/cell. In my mind, it’s what aging undermines. It also makes more sense to talk about restoring system integrity vs. reversing aging.

In new @ScienceMagazine, there are papers from 4 groups describing (super cool) nuclear pore structures. I'd like to use this opportunity to state the obvious - that science is a rich get richer sport. 1/4