Christian van der Werf

@TrackYourHeart I have seen this ECG before...:-) en.m.wikipedia.org/wiki/Catechola…

Teen collapses during exercise. Family hx of sudden death. What’s the diagnosis? #ECG

Defibrillation and refractory ventricular fibrillation academic.oup.com/eurheartj/arti…

Reducing the time interval from emergency call to first shock to six minutes or less could be a key performance indicator of the chain of survival in patients with witnessed out-of-hospital cardiac arrest @HansvanSchuppen @chrisvanderwerf ahajournals.org/doi/abs/10.116…

Association Between Delay to First Shock and Successful First-Shock Ventricular Fibrillation Termination in Patients With Witnessed Out-of-Hospital Cardiac Arrest | Circulation ahajournals.org/doi/abs/10.116…

Top stories in catecholaminergic polymorphic ventricular tachycardia (2022-2024) #OpenAccess heartrhythmjournal.com/article/S1547-…

Risk scores in congenital long QT syndrome: friend or foe? academic.oup.com/eurheartj/adva… #LQTS #risk #score @escardio @ESC_Journals

A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome jamanetwork.com/journals/jama/… @JAMA_current @LHSCCanada Wonderful collaboration on CRDS!

From @JAMA_current: Preliminary results suggest that the repolarization response on an electrocardiogram to brief tachycardia followed by a pause may effectively diagnose calcium release deficiency syndrome (CRDS), a newly described cause of sudden death. ja.ma/3Vwy6h0

@V_Mardigyan @Mo_PedsEP @jodieingles27 @jpkaski @jeffrey_vinocur I don't know, but I think it's low. AV block is not a typical feature of CPVT. Sinus bradycardia is a typical feature, but of course the initiation and dosing of beta blockers will impact incidence of pacing indication and probably has dropped since we have flecainide.

@ChrisvanderWerf @Mo_PedsEP @jodieingles27 @jpkaski @jeffrey_vinocur In your registry, what was the incidence of requiring pacing (either for AV block or symptomatic sinus node dysfunction) among RYR2 gene mutation patients? ahajournals.org/doi/10.1161/ci…

Can RYR2 cause DCM, how strong is the evidence? I have an infant with this mutation and DCM (however was transient and likely viral?). No FH of note. Will do segregation analysis and holter, etc. i did not see the ecg yet. @ChrisvanderWerf @jodieingles27 @jpkaski @jeffrey_vinocur

#OriginalResearch: In patients with CPVT, the addition of flecainide to beta-blocker therapy is associated with a lower incidence of arrhythmic events ahajournals.org/doi/10.1161/CI…

@Mo_PedsEP @jeffrey_vinocur @jodieingles27 @jpkaski @MJAckermanMDPhD @PKannankeril @BehrElijah To my knowledge there is no data on risk stratification. We think that the SCD risk is low and therefore tend to do as much nothing as possible. Only patients with complex VAs at EST (another typical feature) get BBs, sometimes as the cost of a pacemaker.

@jeffrey_vinocur @ChrisvanderWerf @jodieingles27 @jpkaski @MJAckermanMDPhD @PKannankeril @BehrElijah Is there SCA/SCD risk?

Anyone with HCN4 related sinus node dysfunction? My specific family mutation is c.2036 G>A p.(Cys679Tyr) @ChrisvanderWerf @jodieingles27 @jpkaski @MJAckermanMDPhD @jeffrey_vinocur @PKannankeril @BehrElijah

@Mo_PedsEP @seshadribalaji6 Not sure about the additional value of an ILR in an asymptomatic patient, but fully agree with very close noninvasive monitoring and considering LCSD before ICD in case of ventricular ectopy or possible nonadherence

@seshadribalaji6 @ChrisvanderWerf I would at least do loop implant, consider sympathectomy (if that is easy enough) and repeat EST frequently and make sure of compliance

Lost one of my TECRL CPVT pts despite being dx at 14 yrs old bcz of cascade screening (asymptomatic) but with a +ve EST that normalized on nadolol/flecainide (compliant). While my practice is no ICD in asymp & have no breakthrough with tx. Not sure now with atypical CPVT forms?

Celebrating the end of a great #ESCCongress (@escardio) and the success of our @TheLancet Commission on Sudden Cardiac Death with an incredible team. Full commission: authors.elsevier.com/a/1hfK3V-4XL2Nt #CardioTwitter

After 2 years, it is with great pleasure to share the work of our official @thelancet Commission on Sudden Cardiac Death. Thank you to an incredible commission team - it has been an honor to work with you !  authors.elsevier.com/a/1hfK3V-4XL2Nt @ESCardio #ESCCongress #esc2023

Sudden cardiac death (SCD) claims millions of lives each year. A new Lancet Commission calls for bolder strategies to reduce the SCD burden, including improving people’s ability to perform CPR. 📌 hubs.li/Q01_8wDw0 #ESCCongress

Sudden cardiac death causes 4-5 million deaths each year worldwide, demonstrating a more aggressive and target approach to tackling SCD is needed. View our official launch of @thelancet Commission on Sudden Cardiac Death. hubs.li/Q01_8wDw0 @ESCardio #ESCCongress

Sunday is official launch date of @TheLancet commission paper on #SCD. Immensely proud to be part of the commission‼️ And to present major gaps in evidence in CA survivors. Join us #ESCCongress to get unique insights on future research ➡️ (Sunday, Hub Mondrian 8.30AM) #dcs_esc23

Cardioloog en hoogleraar Arthur Wilde ontving een koninklijke #onderscheiding en een Gold Medal van de Europese cardiologievereniging. 🏅 Hij ontdekte de #genafwijking die leidt tot idiopathisch #ventrikelfibrilleren. Meer lezen? ⬇️ bit.ly/47MZhJC