Danny Arends

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Danny Arends

Danny Arends

@DannyArends

Associate Professor at Northumbria University & Lecturencer @ https://t.co/YzuS0whXat

Newcastle upon Tyne, UK Katılım Haziran 2010
121 Takip Edilen569 Takipçiler
Danny Arends
Danny Arends@DannyArends·
@FengYungWang1 @Aging_CEU @Nature That's a really good question, and one that we will hopefully be able to answer in the future. Our initial work on a limited number of Rapamycin treated mice shows that yes there might be a best time window for intervention. But GxDrug is the next step.
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Feng-Yung Wang
Feng-Yung Wang@FengYungWang1·
@DannyArends @Aging_CEU @Nature That's super big work and fantastic findings! One quick question i am curious is whether those "aging intervention" drugs (repaying, metformin) also have an optimal window for the intervention? may be beneficial in young but harmful in elders, or otherway around?
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Danny Arends
Danny Arends@DannyArends·
@DoloffLab @pgonzrodriguez @Nature Vita17a overlaps the MHC, linked to lifespan since the 1970s. Candidate genes at other loci point to lysosomal function, autophagy, fatty acid oxidation as well as mTOR signalling. So immune function does feature, alongside broader metabolic and cellular maintenance pathways.
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Danny Arends
Danny Arends@DannyArends·
@TheBrunoCortex Yep, someone will build a Polygenic Risk Score to predict genetic risk of death at a given age (in mouse).
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Danny Arends
Danny Arends@DannyArends·
@zhaoweiasu @Nature Great question! The honest answer is we don't fully know why. The leading idea is that males and females face fundamentally different reproductive trade-offs that get wired into separate genetic networks over time. A steep price: for some loci yes, they help early and hurt late.
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Wei Zhao
Wei Zhao@zhaoweiasu·
@DannyArends @Nature Congrats! Very interesting study! Any clue why epistatic links are non-overlapping between male and female? Does that mean we have paid a steep price for reproduction, but in totally different way for different sex?
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Danny Arends
Danny Arends@DannyArends·
@hhlee Yes and available for anyone to dig into. Some more discoveries are bound to be hiding in there.
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长青新境（Longevity Foresight）
长青新境（Longevity Foresight）@kksksakana48517·
非常棒的研究！ 我们为大家用最新的Chat GPT Image-2 模型制作了解读图👀 总之：性别、年龄、体重，都对衰老有很大的影响
长青新境（Longevity Foresight） tweet media
Danny Arends@DannyArends

Our paper in @Nature today 🥳 We tracked 6,438 mice from puberty to death and mapped the genetics of *when* you die, not just whether a gene associates with lifespan. nature.com/articles/s4158… 59 loci. Two decades of data. Thread 👇 #Longevity #Aging #Genetics #Healthspan

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Curtis
Curtis@curtinity·
@DannyArends @AllThingsApx Wow this is incredible! Very interesting! Note on the sex differences: Looking at exercise in rats, we were surprised that the *vast majority* of significant active chromatin and transcriptional changes were in only one sex. The common changes were only ~5%!
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Danny Arends
Danny Arends@DannyArends·
4/5 The result that surprised me most: The genetic interaction networks in males and females are almost completely separate 🤯. 78 epistatic links in males, 72 in females. Only 2 overlap. If you ignore sex in aging genetics, you get the wrong answer. Full stop.
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Danny Arends
Danny Arends@DannyArends·
@Aayush13138763 I really enjoy seeing code grow and adapt more features over time. The basic web server grew out of serving unsecure https 1.0 in a request response loop. Its current form does multiple HTTPS domains on 1 ip using SNI and ACME renewal, supports keep alive and streaming video.
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Keşfet

@FengYungWang1 @Aging_CEU @Nature @DoloffLab @pgonzrodriguez @TheBrunoCortex @rbrennan12 @Supergecko