Jacob M. Dundee, PhD

Connect with me on bluesky! Not leaving X but always looking for new places to learn about #microglia and #neurodegeneration!

I’m happy to be formally selected as the category winner in neuroscience for the 2026 𝗧𝗮𝗸𝗲𝗱𝗮 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗼𝗿𝘀 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝘄𝗮𝗿𝗱 𝘄𝗶𝘁𝗵 𝗡𝗮𝘁𝘂𝗿𝗲 @TakedaPharma @Nature, in recognition of my pioneering contributions to 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗿𝗲𝗽𝗹𝗮𝗰𝗲𝗺𝗲𝗻𝘁. nature.com/immersive/inno…

Neuronal subtype governs #amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models Gabriella A. Perez, Zoe Lai...Joanna L. Jankowsky @bcmhouston @washumedicine #AlzheimersDisease #GABAergic link.springer.com/article/10.118…

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

I’m thrilled to announce that I have been awarded an @alzassociation grant for my research into the "Functional and transcriptional characterization of TMEM106B in tauopathy". With this funding, I aim to uncover potential roles of TMEM106B in AD and beyond! 👨‍🔬🔬🧠 #ALZFunded

My recent @NIH Director’s series lecture summarizing 10 years of the lab’s work related to brain drainage and CNS immune surveillance || Navigating Unchartered (Neuroimmune) Waters youtu.be/YWFOhhw-jxA?si… via @YouTube

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @UKDRI @ucl - pls help circulate among networks who’d be of interest, thank you!

@eyolab Never gets old looking at some pretty microglia 🤩

20 years ago, the 1st in vivo imaging studies of MG led by Axel Nimmerjahn and Dimitrios Davalos were published. They contradicted the then-prevailing idea that MG as “quiescent” cells in the brain and showed MG basal and chemotactic surveillant dynamics.🤩#20YearsInVivoMGImaging

@dolanmjg Great to see you are doing well!

Our lab website is up! We are hiring at all levels. dolanlab-tcd.com

‼️BIG news ‼️ #ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing! Hurry up to register while prices are low! See you in Boston in October! @kipnislab @IdoAmitLab @QuintanaLabHMS @stevens1lab @RejaneRua genelayinstitute.org/rtn/

Thrilled to share my latest paper in @MolNeuro where we demonstrate that the knock-down of GPNMB via ASOs in myeloid cells from preclinical models and FTD-GRN patients perturbs lysosomal function and increases immune responses 1/5 🧵 bit.ly/3Ed5ULn

📢 New webinar coming soon 📢  Prof. Steffen Jung from @WeizmannScience will be our next speaker on April 1st. Check all the information in the flyer and add it to your calendar!

The program is now finalized for the 2nd annual Hans J. Müller-Eberhard Symposium on Neuroimmunology and Glial Biology! The event will be held @CNG_UTHealth at Institute of Molecular Medicine @McGovernMed @UTHealthHouston. Thanks all committed speakers and sponsors! Stay tuned!

Our new paper is in print form: Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks 1/ academic.oup.com/brain/article/…

'#APOE Christchurch enhances a disease-associated #microglial response to #plaque but suppresses response to tau pathology' Kristine M. Tran, Nellie E. Kwang...Grant R. MacGregor & Kim N. Green @UCIrvine @UCIBioSci #AlzheimersDisease bit.ly/4h7SUoG

Amyloid strengthens synaptic connections between regions loaded with neurofibrillary tangles, fueling the propagation of tauopathy in AD. @LMU_Muenchen ow.ly/Ynzo50UMfg7

The #SynpaticPruningDebate rages on with an impressive level of LIVE IMAGING support from this work (albeit in co-culture). An unique documentation of microglial surveillance in culture (the best to date?!) What a beautiful study @ryuta_koyama!!!!! 🤯🤩👏🏾nature.com/articles/s4146…

Are you using 5xFAD mice to study Alzheimer’s disease? Our work @NeuroCellPress may be relevant to you 🐁 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. (1/11) cell.com/neuron/fulltex…

Microglia lovers listen.... nature.com/articles/s4146…

Inhaled xenon shifts microglia into a phagocytic state, suppressing amyloidosis in mouse models. A Phase 1 trial has started. #alzheimersdisease @BrighamWomens @wustl ow.ly/s1xO50UIEvj