Delphine Le Grand

@hubermanlab Definitely not AI, local Brooklyn bodega right next to where I live 😅😅

If this isn’t AI then very concerning. GH? Reta? At the corner mart?! With your energy drink? I saw GLPs advertised for sale by sidewalk sign on the Upper East Side of NYC a few years back but this is different. Third party independent testing is needed for all peptides IMO.

For the first time in 3 years I had a 4 day stretch where I didn’t get my usual sun exposure I felt absolutely terrible. Then I remembered this was my “normal” before I took the circadian and sun pill Imagine a patient locked inside the hospital for days or weeks…

@chrissyfarr Would love to chat @chrissyfarr ! Building Protocole (theprotocole.com) - many women also on our platform, current demo about 50/50

I typed in 'peptides' into X search for ideas on who I should interview for my podcast on the topic and I'm so far 96 tweets deep of only men talking about it. Are there any women who know about peptides? Or is it true this is astrology for men?

The last generation of tech founders ran on Adderall and caffeine. The next generation will run on Semax and Selank and Pinealon

Since being in Costa Rica my sleep and energy has improved 10x. In New York (where I live) no matter how many supplements/lifestyle changes I made, never achieved the same results

Ive seen many people successfully recover from injuries with regenerative peptides like BPC / TB / KPV. My dad had a knee injury, tried PT, acupuncture, offered only temporarily relief. One cycle of BPC decreased pain significantly. He still continued doing PT, but results would not have been the same without bpc.

@jms_tny Creatine brand doesn’t matter and aside from GLP-1s I can’t tell if any other peptides like BPC/TB/Gk/GHRPs do much of anything. Not feeding u tho sorry.

who wants to tell me about peptides? who wants to tell me if the brand of creatine i take matters? who wants to put 3 day old rice and ground beef on a spoon and say “here comes the airplane” and feed me

@mc_khristina This link should work! members.theprotocole.com/account/regist…

@DelphineLG I was only able to join the waitlist and just checked now and I still only see a waitlist option ...

Peptides- I have seen several X posts recently about peptides and have been inundated on other social media with claims of the various benefits of peptides ... so I am intrigued. In a reply post the other day @DelphineLG mentioned Building Protocole. This is apparently a new, physician guided membership platform providing access to medical-grade peptides from trusted U.S. pharmacies. SO, I am even more intrigued ("physician oversight, premium-grade compounds, and clear guidance") ... I was just on their website and joined a 'waitlist'... they said if I share this URL I move up the waitlist ... so here is to sharing! 🫶☺️ theprotocole.com/?referralCode=…

@nothoontz @DrJesseMorse BPC + TB500 + GHK + KPV

@DrJesseMorse What kind of peptides would you recommend for someone with a torn disc in the low back

Life is short. Don’t take it for granted. Here one day, gone the next. Live life to the fullest!

@CoachDanGo Disagree. It’s an incredibly effective tool when paired with good habits. Lifestyle interventions remain the foundation, but when GLPs are used to support behavior change, they don’t have to be lifelong. I’ve worked with many people who’ve tapered off and maintained results.

For most people, taking a GLP-1 is a lifetime subscription. It's the same as someone who changes their diet, exercise, cardio, etc. The tools you use to lose weight are the ones you'll need to keep it off.

@mc_khristina @jflood215 @alc2022 Khristina - Building Protocole (theprotocole.com) physician guided peptide protocols. Just opened up membership applications. Happy to share more info!

@jflood215 @alc2022 thank you. I’ve seen a lot of social media marketing for peptides and various companies, but definitely hesitant to order anything if I don’t know how pure and where it is coming from. 🙏🏻

@MitoPsychoBio Look forward to listening! @MitoPsychoBio

Energy flow is the essence of what we are. Even in the absence of any molecular defect, abnormal energy flow can cause disease. It is time to understand health from first principles.

@ChrisStelzer_ @AbudBakri DM me! Building Protocole (theprotocole.com) physician guided peptide protocols. Just opened up membership applications

@AbudBakri Abud, where can I get legit peptides? I'm assuming talking w/ my doc? The restoration of melatonin production is very interesting...

This is restoration not hacking

@anothercohen @ShawnIsakson Such a kind gesture!

@ShawnIsakson Yes one dumbbell per box and I tipped the UPS driver with a Celsius

Home gym dumbbell set complete ✔️

@hubermanlab @Brady_H @Michael_Easter Most top athletes work with doctors who manage peptide use deliberately. It’s one of those things where everyone knows about it, but rarely talks about

@Brady_H @Michael_Easter Careful about peptide stance. Most of the guys you will run against this year are already taking peptides. Legally. TRT is another matter. But peptides are rampant in all sports now. It’s “supplements plus”… and they won’t be banned (most anyway)’

Holy sh*t. The New Food Pyramid is out, and it’s insane.

@GCH6888 @doctormorphh At protocole we work with many members on reta - no one has reported this yet

@doctormorphh Does retatrutide diminish/attenuate libido too? I have heard that people have less sexual desire when on.

Lots of people also talk about having blunted motivation and feeling flat on Retatrutide Why is that? GLP-1 its inhibition is ligand selective, so for example it would attenuate alcohol or cocaine reward/addiction signaling while having no effects per se at normal drug free activity. Baseline GLP-1 receptor activation doenst blunt dopamine it only blunts the supraphysiological spikes. This prevents pathological reinforcement, avoiding the side effect of global anhedonia or emotional blunting. Blunted neurochemical reward in the presence of substances like cocaine, nicotine, or alcohol is due to GLP-1 directly suppressing the magnitude of extracellular dopamine spikes, resulting in diminished efficacy of addictive substances by essentially capping their intensity. GLP-1 also upregulates dopamine transporters (DAT) which enhances surface expression and uptake capacity of DATs. This accelerates the reuptake of dopamine from the synaptic cleft resulting in more precise dopamine signaling via clearing dopamine more rapidly GLP-1 receptor activation accelerates dopamine metabolite turnover within the amygdala, where dopamine excites it otherwise resulting in anxiety, so blunting dopamine here is good. It also maintains the structural integrity of dopamine neurons, via preserving things like TH and VMAT2 meaning neuroprotective benefits, protecting the motor and motivational circuitry against degeneration and maintaining the functional viability of the nigrostriatal pathway. This is exceptionally good in cases like Parkinons where its also exceptionally good for insulin signaling in the brain. Bottom line -> If you have blunted motivation from GLP-1 you were getting your dopamine from the wrong sources.

@Floridagirl0850 Right answer!

I don't care about expensive bags or clothes in 2026; all my money is going to skin lasers, peptides, and protein.

@drmikehart Whats the main goal?

Gave some BPC-157 to my dog 🐶 Will let you know how it goes

@AbudBakri Nothing sunshine, good friends and purpose can’t fix :)

@DelphineLG Changing latitude based on seasons is priceless! Geographic circadian time travel

I can't believe sunlight is free Such a powerful health tool The expensive part is designing life in a way that allows you to access it during critical periods during the day, such as daybreak, UVA rise, skin-color appropriate UVB sessions, and sunset.