Dr. Yamil Matuk

Efficacy, safety and predictors of response to electroconvulsive therapy in Lewy body disease #ECT #Electroconvulsive #LBD #Lewybodydisease In the May 2026 PRD journal (In the Spotlight) prd-journal.com/article/S1353-…

Un orgullo publicar este artículo con mis compañeros clínicos e investigadores en @ParkinsonismD , concluimos: 1.- Antecedente de traumatismo craneoencefálico repetido (≥2 TCE) se asoció con mayor riesgo de desarrollar enfermedad de Parkinson, aumentando más del doble la probabilidad de padecerla. 2.- Los hombres con antecedente de TCE mostraron una asociación significativamente mayor con Parkinson comparado con mujeres, sugiriendo diferencias biológicas y ambientales relacionadas con el sexo. 3.- El estudio refuerza la hipótesis de que el TCE podría actuar como factor ambiental no genético en Parkinson, posiblemente mediante neuroinflamación crónica y acumulación de alfa-sinucleína, aunque se requieren estudios longitudinales para demostrar causalidad.

Frequency of dementia with lewy bodies in a large memory clinic in Colombia: Results from a 6-month cross-sectional study using the lewy body composite risk score @PRDAssociation In Apr 2026 In the Spotlight PRD Free full article prd-journal.com/article/S1353-…

Longitudinal MRI study of hippocampal subfields Morphometry in early Parkinson's disease #MRI #hippocampal #Parkinson #PRD #morphometry @PRDAssociation Log in to May 2026 PRD

@LuisOliverio En cuanto al avance, trístemente, me atrevo a decir prácticamente nada…

La revisión de hoy de Esclerosis Lateral Amiotrófica (ELA), una interesante y fatal enfermedad en la que hemos avanzado... casi nada. De JAMA (2026). Puntos clave: 🔴 La sospecha inicial debe enfocarse en la coexistencia progresiva e indolora de signos de motoneurona superior (espasticidad, hiperreflexia, reflejos patológicos) y motoneurona inferior (atrofia, debilidad, fasciculaciones, hiporreflexia). Primero suele ser focal, pero se disemina con el tiempo. 🔴El diagnóstico sigue siendo predominantemente clínico. La electromiografía es la herramienta de apoyo principal para demostrar denervación activa y reinervación crónica, pero sobre todo, es vital para excluir diagnósticos diferenciales (miopatías, neuropatías, miastenia). No existe ningún biomarcador diagnóstico definitivo. 🔴 Idealmente incluir paneles genéticos a todos los pacientes diagnosticados con ELA, no solo a los que tienen historia familiar. Aunque el 85% de los casos son esporádicos, identificar variantes genéticas es importante. El gen SOD1 tiene una diana terapéutica ya. 🔴 Hay +60 genes asociados a la ELA, pero el hallazgo neuropatológico en 97% es la mislocalización nuclear y la agregación citoplasmática de la proteína TDP-43 🔴 Sigue siendo fatal con una supervivencia de 3-5 años. Los fármacos orales aprobados (Riluzol y Edaravona) ofrecen un beneficio clínico apenas marginal. El manejo sintomático mediante equipos multidisciplinarios impacta más en la supervivencia. Tofersén es prometedor, una terapia antisentido intratecal que disminuye la progresión exclusivamente en el subgrupo de pacientes con mutación SOD1. Pueden leerlo completo en el canal (t.me/memodiappartic…).

Mozart: Piano Concerto No. 23: II. Adagio Composed in 1786 Hélène Grimaud youtu.be/j8e0fBlvEMQ?si… via @YouTube

Excellent viewpoint article on mitochondrial Parkinson's disease by Percetti and colleagues. loom.ly/sj3wYNs

May 2026 PRD… Directional functional influence of the locus coeruleus on the whole brain in tremor-dominant and akinetic-rigid Parkinson's disease #locuscoeruleus #Parkinson #PD prd-journal.com/article/S1353-…

From JAMA: Amyotrophic lateral sclerosis (#ALS) is an adult-onset neurodegenerative disorder characterized by progressive muscle weakness due to degeneration of upper motor neurons in the brain and lower motor neurons in the brainstem and spinal cord. ja.ma/4eEd8rM

Seizures are described as with or without observable manifestations (basic) or by the chronological sequence of semiology (expanded). READ THIS INFORMATIVE PAPER. Click the link doi.org/10.1002/epd2.7…

Bladder and sexual symptoms are frequently brain symptoms hiding in plain sight. The nervous system includes the brain, spinal cord and nerves that control how organs function, including urination and sexual response. Sakakibara and colleagues describe in a new paper in Nature Reviews Neurology how urogenital dysfunction is tightly linked to the brain and broader nervous system in neurological disease. Key Points: - The bladder and sexual organs are under both automatic and voluntary brain control, making them unique among body systems. - Brain circuits involving the prefrontal cortex, basal ganglia and brainstem actively regulate storage and voiding, and disruption leads to symptoms like urgency or retention. - Dopamine and other neurotransmitters that are central to disorders like Parkinson’s disease also directly influence bladder control and sexual function. My take: We too frequently think about bladder and sexual dysfunction as local organ problems, however this paper reinforces they can be brain/nervous system network problems. If we miss this connection, we miss early diagnosis, better treatments and a chance to improve quality of life in a meaningful way. Here are 5 points that resonated w/ me: 1- Bladder symptoms may be an early signal of brain disease and should trigger a neurological lens. 2- Sexual dysfunction is tightly linked to brain circuits for emotion, motivation and dopamine signaling. 3- Conditions like Parkinson’s disease, stroke and dementia frequently disrupt these networks leading to urogenital symptoms. 4- Treating the brain and not just the bladder or genital organs may lead to better outcomes for many folks. 5- Health care providers should routinely ask about these symptoms as they are common, underreported and highly treatable. nature.com/articles/s4158… #parkinson @ParkinsonDotOrg

Enjoy! iies.unam.mx/libros/Manual-…

Jake Sossamon, PGY-1 Stanford Neurology resident, has launched The History of Neurology Podcast to explore the human drama, wartime breakthroughs, and accidental discoveries that shaped our specialty. Episode 1: "The 'L' is Not Silent: The Secret History of Guillain-Barré" can be found on Spotify, Apple Podcasts, or Amazon Podcasts. podcasts.apple.com/us/podcast/his…

Mecanismo de acción de la neurotoxina botulínica en la unión neuromuscular: N Engl J Med 2026;394:1011-7.

Development and International Validation of a Novel Imaging-Based Risk Score (IsCHEMiA) for the Prediction of Poststroke Epilepsy | Neurology neurology.org/doi/10.1212/WN…

Parkinson’s disease has the fastest-growing prevalence of any neurodegenerative disorder worldwide go.nature.com/4r0zozh

Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson Disease jamanetwork.com/journals/jaman…

For people with Parkinson’s, quality of life is personal, adaptable, and shaped by what supports their well-being. Health can help or hinder it. Listening to these perspectives can improve care, interventions, and how we measure what truly matters. loom.ly/H4PJcTU

Restless legs syndrome (RLS), a sleep-related movement disorder, is present in approximately 3% of adults worldwide. 📌 This Review summarizes the pathophysiology, epidemiology, risk factors, diagnosis, treatment, and prognosis of RLS: ja.ma/4jXiPBv

💬 Viewpoint: FDA-cleared blood tests for #AlzheimerDisease improve diagnostic access but may lead to misdiagnosis, disparities, and legal or psychological harms without careful risk mitigation. ja.ma/4k1WnY2