Congrats to Andreas and Yue for the best paper award! #eau24 sciencedirect.com/science/articl…
English
Günter Niegisch
117 posts
Günter Niegisch retweetledi
JUST IN: @US_FDA alert: FDA approves nivolumab in combination with cisplatin and gemcitabine for unresectable or metastatic urothelial carcinoma! Via @ASCO @US_FDA alert !
Trial presented @myESMO #ESMO23 and published @NEJM
@OncoAlert @MattGalsky @sonpavde @MichvdHeijden
English
Günter Niegisch retweetledi
No matter how you splice it , analyze it or criticize it .. this is hope .. something we have not been able to say in a very very long time for many of our #bladdercancer patients and I am here for it
NEJM@NEJM
In a trial comparing enfortumab vedotin and a PD-1 inhibitor with chemotherapy in patients with untreated advanced or metastatic urothelial cancer, progression-free and overall survival nearly doubled with the experimental treatment. Full trial results: nej.md/49ViJEe
Richfield, OH 🇺🇸 English
@tompowles1 @NEJM Congrats to @tompowles1 and the whole EV-302 study team for this important work. Writing the editorial was an honor!
English
Enfortumab + Pembro outperforms platinum chemotherapy in advanced UC with a doubling of PFS and a halving of the risk of death @nejm. G3/4 AEs of 56% for EVP vs 70% for chemo & CR=29%. Editorial by @gniegisch ‘EVP is the new standard against which future trials must be compared’
English
Online now! Enfortumab Vedotin and Pembrolizumab — A New Perspective on Urothelial Cancer | NEJM nejm.org/doi/full/10.10…
English
Insightful case discussion with an outstanding panel at #emuc23 with @amerseburger @DrYukselUrun , Kerstin Junker, N.Sanmamed and H. Thoeny!
English
Günter Niegisch retweetledi
CheckMate 901 folks #ESMO23 @BladderCancerUS @TischCancer @sonpavde @MichvdHeijden @DrYukselUrun
nejm.org/doi/full/10.10…
English
Günter Niegisch retweetledi
#Goosebumps #EV302 #ESMO23
Took 3 decades but a new SOC in 1L bladder cancer !!!!!! @tompowles1
EV+Pembro irrespective…..WOW! 🤩
English
Günter Niegisch retweetledi
🔥Breaking News at #ESMO2023!🔥 EV302 is changing the game, unbelievable data (HR=0.45!!!) for metastatic urothelial cancer patients, really an evolution #EV302. Terrific presentation by @tompowles1. 🙌🔬🎗️ @urotoday @OncoAlert @myESMO
English
Günter Niegisch retweetledi
EV-302/Keynote-A39 game changer in mBCa
OS 31.5 mo vs 16.1 👏🏼
Standing ovations for @tompowles1
@OncoAlert @myESMO @Silke_Gillessen
English
Günter Niegisch retweetledi
Latest Publication by our
Düsseldorf UroRad group
sciencedirect.com/science/articl…
Deutsch
Online now: DARO safety data in comorbid patients!
Efficacy and safety outcomes of darolutamide in patients with non-meta... sciencedirect.com/science/articl…
English
Günter Niegisch retweetledi
🆕 Do not perform immediate cytoreductive nephrectomy in intermediate-risk patients who have an asymptomatic synchronous primary tumour and require systemic therapy.
#RenalCellCarcinoma #EAUguidelines
uroweb.org/guidelines/ren…
English
Günter Niegisch retweetledi
The addition of Talazoparib(PARPi) to enza in CRPC has most effect in BRCA+ve tumors. Effects in the remaining HRR population are marginal or -ve (e.g. ATM). This is largely consistent with previous data for PARPi in CRPC, supporting the ODAC decision on olaparib #ASCO2023
English
@shilpaonc @AmerUrological @PGrivasMDPhD @MaxKates @UroDocAsh @UrogerliMD @ValGraj @drtanws Or radiotherapy.....
English
Happening now! #AUA23 @AmerUrological
Debate b/w @PGrivasMDPhD &
@MaxKates on optimal mgt of T3N2 Bladderca after platinum chemo. Surg or maintenance avelumab? @UroDocAsh
@UrogerliMD @ValGraj
@drtanws
English
@shilpaonc @AndreaNecchi @AmerUrological @PGrivasMDPhD @MaxKates @UroDocAsh @UrogerliMD @ValGraj @drtanws Surgery (if fit) followed by maintenance. Local treatment may have an impact upon systemic treatment only (doi.org/10.1200%2FJCO.…, though this was CTx w/o maintenance).
English
@AndreaNecchi @AmerUrological @PGrivasMDPhD @MaxKates @UroDocAsh @UrogerliMD @ValGraj @drtanws Medoncs are in a minority here😬
English
@SpreuThomas @Mohamedendourol @drkemalsarica @sbinhamrii @JnsHerrmann @joanfundi Perineal drainage, suprapubic catheter and IV antibiotics. Then reasses by CT scan/MRI when infection is controlled.
English
Apparently, if you can see two people hugging, you're left-brained, and if you can see a dinosaur, you're right-brained. What do you see in the mountain?
English