@UCCpsychiatry It's striking how much microbiome-gut-brain axis research is concentrated in HICs. Population diversity isn't just a variable to control for, it's a source of discovery we're leaving untapped.
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Philipp Doc
3.8K posts
Philipp Doc
@GamerPhilDoc
Gaming-, Koch- und Gewichtheben-Enthusiast. 🎮💪
Munich Katılım Mart 2023
287 Takip Edilen204 Takipçiler
Global mental health benefits from expanding microbiome–gut–brain axis research to the global south
nature.com/articles/s4422…
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@ZakariaMDv3 Interesting preclinical signals, but we're far from clinical application. Drug repurposing in oncology needs controlled trials, not anecdotal cycling regimens with binders and glutathione.
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🚨 Ivermectin for Cancer: The Important Part Most People Miss
Ivermectin is being explored for its potential anti-cancer effects; it can disrupt cancer cell mitochondria, interfere with glucose metabolism, and help reactivate apoptosis (the cell’s natural self-destruct system).
But here’s what often gets overlooked: Ivermectin can also place extra demand on your body’s detoxification pathways.
Supporting your terrain while using it is essential.
Here’s how this person supports their body during use:
Liposomal glutathione + NAC for liver and mitochondrial support
Binders like activated charcoal and fulvic acid to help with detoxification
Cycling protocol: 5 days on, 2 days off
As they put it:
“Ivermectin may help starve the tumor, but don’t starve your terrain in the process.”
This approach combines the potential benefits with practical ways to protect overall health.
Follow me for more updates.
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@iScienceLuvr They note projects hitting bio classifiers 'may be eligible for exemptions.' That reads like case-by-case review, not safeguards off entirely.
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Does Anthtopic disable their "safeguards" for researchers who receive this grant?
Anthropic@AnthropicAI
We're offering grants of up to $50,000 in Claude usage credits to researchers accelerating cures for rare diseases. This is our first focused call within AI for Science, our program supporting scientists using Claude to speed up discovery. anthropic.com/news/rare-dise…
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T-cell exhaustion and immune evasion in rare cancers still don't get enough research attention. Good to see AACR giving this dedicated focus.
AACR@AACR
#AACRrarecancers26 cochair Taran Gujral adjourned the AACR Special Conference on Breaking Barriers in the Fight Against Rare Cancers. We thank the cochairs, invited speakers, and abstract presenters for their contributions to this groundbreaking program.
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This kind of spatial profiling is exactly what's been missing in immunotherapy response prediction. If CAF archetypes vary this much within a single TME, it's no wonder biomarkers from bulk tissue have been underwhelming.
Cancer Cell@Cancer_Cell
Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts dlvr.it/TTdHNl
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@meddly @JAMAInternalMed Interesting. Would be curious whether these patterns hold across specialties. In haematology, testing decisions seem driven more by case complexity than physician gender alone.
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🚨New paper!🚨Who orders more testing: male physicians or female physicians? And what are the implications on patient outcomes? We examine these questions in the emergency department (ED) in @JAMAInternalMed.🧵1/
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The 2-week turnaround is what makes this clinically relevant. Most organoid platforms are too slow for real therapeutic decisions. But 10 TB of data per run? That's going to be the actual bottleneck for many labs.
The ASCO Post@ASCOPost
🖥️ #ASCOAI: Machine learning ➕ 3D bioprinting ➕ label-free imaging A new protocol enables high-throughput drug response profiling in tumor organoids, helping identify treatment response patterns that could support #precisiononcology. Learn more ➡️ ascoai.org/articles/2026/…
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Hundreds of pre-clinical papers on ivermectin and cancer pathways exist. But in vitro activity rarely translates into clinical outcomes. That distinction is everything.
Joe Tippens@JoeTippen
🚨 “PEOPLE STILL CALL IVERMECTIN A HORSE DRUG… EVEN AFTER THE NOBEL PRIZE.” That single sentence is why this conversation keeps exploding online. In a now viral discussion, doctors and researchers brought up something most people STILL have no idea exists: There are hundreds of published papers exploring how Ivermectin may interact with cancer pathways at the cellular level. Not memes. Not TikTok theories. But Aactual pre-clinical cancer research. Researchers have studied: ✅ Cancer stem cell activity ✅ Tumor metabolism ✅ Drug resistance pathways ✅ Programmed cancer cell death (apoptosis) ✅ Combination effects alongside chemotherapy. And THAT is what’s making people ask a very uncomfortable question: Why do most people know almost NOTHING about this research? Especially when: • Ivermectin has decades of human use worldwide • It helped earn the 2015 Nobel Prize in Medicine • Scientists are still actively publishing new studies on its mechanisms. But whether critics like it or not… The public conversation around repurposed medicine is becoming impossible to ignore. That’s why more people are now researching Ivermectin, Fenbendazole, and Mebendazole for themselves.
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@DFCI_BreastOnc @ShoshRosenberg @HutchPresident @ValenzaCarmine @ProfAMThompson @AnnPartridgeMD @DrShelleyHwang Interesting that depression but not anxiety mediated the age-PPSP link. Wonder if this pattern holds in other surgical contexts or is specific to breast lesion procedures.
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New Pub 👉Age-related differences in psychological distress and persistent postsurgical pain after surgery for management of non-invasive breast lesions.
pubmed.ncbi.nlm.nih.gov/42257780/
✍️@ShoshRosenberg @HutchPresident @ValenzaCarmine @ProfAMThompson @AnnPartridgeMD @DrShelleyHwang #DCIS
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@DrYukselUrun @PGrivasMDPhD @DrChoueiri @chadinabhan @LeonidasPlatan1 @drenriquegrande @g_develasco @scserendipity1 @Dr_AmerZeidan @DrFelixGuerrero @carlosalcaraz The real debate isn't whether baklava is required. It's pistachio vs walnut. And Antep pistachios win every time.
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If your World Cup victory doesn’t end with a tray of Gaziantep 🇹🇷 baklava… did you really win? 🇪🇸🥮😄
The World Cup is over.
The baklava debate has just begun…
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@MohammedAlo @MohammedAlo Inflammation following retention, not preceding it. Same shift happened in immunology. Inflammation is downstream of antigen persistence, not the initiator.
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LDL has to be in the artery wall for plaque to even get started, and that part is not up for debate. Inflammation absolutely makes things worse, but every large trial that tried to reduce heart attacks by targeting inflammation alone, without touching LDL, came up empty. So yes, both matter, but LDL is the necessary cause and inflammation is the accelerant.
dralo.net/blog/inflammat…
dralo.net/blog/response-…
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🚨 The cholesterol rules just changed. And if your doctor is still just maxing your statin dose with no target, they are already behind. The 2026 guidelines ended an era. For years, cardiologists prescribed the highest statin a patient could tolerate and hoped for the best. No
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Philipp Doc retweetledi
For patients with ALK-positive lung cancer, surgery may remove the tumor—but it does not eliminate the threat of relapse. The ELEVATE Trial out in NEJM
The #WeekInOncology by @OncoAlert 🚨 Dr. Uğur Özkerim 🇹🇷 breaks down his top #LungCancer 🫁 picks:
@peters_solange
@christine_lovly
@GlopesMd
@DrSanjayPopat
@StephenVLiu
@HenningWillers
@HHorinouchi
@BRicciutiMD
@PercyLeeMD
@jillfeldman4
bensolomon1
@Latinamd
@DrJNaidoo
@barlesi
@UOzkerim
@FernandoOnco
@DrMirallas
@VanitaNoronha
@NarjustFlorezMD
@MartinReck2
@realbowtiedoc
@FernandoOnco
@ElisaAgostinett
@to_be_elizabeth
@MarioBalsaMD
@BRicciutiMD
@HHorinouchi
@UOzkerim
@p_ciracimd
@AmandaNizamMD
@scocmem
@DrVilmaPBarcia
@DraMartinezLago
@DrMirallas
@nataliagandur
@GIMedOnc
@DaisukeKotani
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In biotech we see this constantly. Decades of foundational research before a single breakthrough gets noticed.
The Nobel Prize@NobelPrize
How did physics laureate Geoffrey Hinton react to the news of his Nobel Prize in 2024? He shared his first reactions with us: "My first reaction was, well wait a minute. I don’t do physics. This could be a prank. I thought it might well be a prank. But then what he said sounded very plausible. Then other Swedish accents came on, and I was convinced it was real. Well, I was sort of convinced it was real, but for a couple of days after that, I thought I might be in a dream. So I did a bit of statistical reasoning, and the statistical reasoning goes like this: What’s the chance that someone who’s really a psychologist trying to understand how the brain works will get the Nobel Prize in Physics? Well, let’s say the chance is one in two million. That’s a fairly generous estimate of the chance. What’s the chance that if it’s my dream, I get the Nobel Prize in Physics? Well, let’s say the chance is one in two. Now you’ve got, it’s a million times more likely that this is a dream than that it’s reality. I thought it might be like those dreams you have when you’re younger that you can fly and it’s wonderful, and then you wake up and it was only a dream. Then a month later you have a dream that you can fly again. And you remember that you had a dream that you could fly and it wasn’t true. But this time it’s real. I thought it might be one of those. So for a couple of days I was sort of waiting to see if I would wake up. I haven’t woken up yet." Read our full interview: nobelprize.org/prizes/physics… Photo: Christopher Michel
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@gcfmd @MKeykhaeiMD @SJGreene_md @JavedButler1 @hvanspall @ATSandhu @AndrewJSauer @HFSA @AAHFN @boback @ankeetbhatt The clinical and economic case for full quadruple GDMT has been clear for a while. So why does implementation still lag so far behind in practice?
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🛠️ ARNI ➕ 🛡️ β-blocker➕ 🧪 MRA ➕ 🍬 SGLT2i
Invest:
💊 cost ~ $1 per day
Receive:
🏖️ ⤴️ HRQoL
☠️ ⬇️ by 74%
HF 🏨 ⬇️ by 85%
🏨 cost saving ~ $64 per day
jamanetwork.com/journals/jamac…
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Philipp Doc retweetledi
Current NICE guidance recommends starting treatment based on age and patient characteristics, then stepping up therapy if blood pressure remains above target.
Use either an ACE inhibitor or an ARB, not both together.
Reference: nice.org.uk/guidance/ng136
#MedTwitter #Hypertension #Cardiology #InternalMedicine
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@Sadeer_AlKindi @NIH Well deserved. Using widely available inputs like CT and ECG rather than specialized imaging is what makes AI in cardiology actually useful.
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Grateful to the @nih #NHLBI for supporting this 4 year R01 and to our outstanding team and collaborators. Excited to advance AI-driven CV imaging and improve patient care. It started as a question in the clinic #TeamScience #CardioTwitter #MedAI
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@HelenBranswell Conflicting primate studies with n=3-4 per group tell us almost nothing. But with 500+ cases in a conflict zone and no targeted vaccine, I wouldn't keep the evidence bar where it normally sits.
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There is a bit of evidence to suggest vaccines to protect against other species of #Ebola might offer cross protection against #Bundibugyo, the cause of the DRC outbreak. I wrote about it here: statnews.com/2026/05/18/ebo…
Looks like it may be studied: bloomberg.com/news/articles/…
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@AJOG_thegray Good methodology. Sequential washings at three stages plus immunohistochemistry confirmation gives this real rigor. The pre-morcellation spillover finding is what matters here. That's where the actual risk seems to lie.
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Does contained manual morcellation in minimally invasive hysterectomy prevent myometrial cell spillage? Evidence from sequential pelvic washings ow.ly/y4GS50ZpXqg
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@IJMS_MDPI Interesting special issue. The connection between fungal pathogens and immune evasion mechanisms is particularly relevant to understanding T-cell dysfunction in chronic infections.
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🌟Calling for Papers🌟
📚Recent Advances in #Fungal–Host Interactions
👨🔬Guest Editor: Dr. Julliana Ribeiro Alves Santos
🔗 Find Out More: mdpi.com/journal/ijms/s…
⏰Submission Deadline: 30 January 2027
#CallforPapers #OpenAccess #MDPIIJMS #hostinteraction #antifungal
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Philipp Doc retweetledi
⭐#CallforPapers⭐
📚Environmental Contaminants and Health: Biological Effects, Molecular Mechanisms, and Protective Strategies
👨🔬Guest Editor: Dr. Massimo Venditti, Prof. Dr. Gabriella Chieffi Baccari
🔗mdpi.com/journal/ijms/s…
⏰Submission Deadline: 31 Jan 2027
#MDPIIJMS
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