Janos Groh

Now published in the June issue @NatureNeuro I am especially happy that the artwork my 4-year-old son created (with a little help) was chosen for the cover. #Glial cells in diverse hues as paint splotches, CD8+ #Tcells in red, aberrant #myelin in purple. Thanks @ElisaFlo04 & co!

Thrilled to share our invited Nature Reviews Neuroscience review on the role of peripheral immunity in Alzheimer’s disease. Honored to write this piece with outstanding colleagues @KuchrooLab, @RudyTanzi, @weinerlabhms, Mehdi Jorfi and rising stars from my lab Neta Rosenzweig and Kilian Kleemann. My sincere thanks to Editor Katherine Whalley for the invitation. The time has come to deeply investigate peripheral immunity in AD.

Online now: Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions dlvr.it/TNy4x2

How is the persistence of compartmentalized inflammation sustained in MS? Our new study in @ImmunityCP offers some hints. cell.com/immunity/fullt… Congrats @fngruqng2, @LenaSpieth, @LuLiu_Laura, @StefanBerghoff, @vinitiwari1 et al.

Join us 10/30 for a @Labroots webinar with Dr. Janos Groh: From Myelin Damage to Immune Dysfunction: Unravelling the Aging Brain. Hear how single-cell + spatial transcriptomics reveal glial–immune interactions driving neurodegeneration. Register: hubs.ly/Q03N0rVJ0

When it comes to aging, the health of even the smallest vessels is critical to maintaining cognitive function. New study in @Nature finds that deterioration of the brain's drainage system contributes to reduced blood supply in deep white matter: nature.com/articles/s4159…

Happy to share this review article published in @RockUPress @JExpMed today. Thankyou Mika and @Lucie_JExpMed for the opportunity !! 🥳 @UCSDHealth @TU_Muenchen @DZNE_en #Microglia #Inflammation #Lipids #CNS

Are T cells in the brain friend or foe? In tauopathy mice, CD8⁺ T cells can slow pathology. In older, wild-type mice, they damage the optic nerve. (@NINDSnews @NIH @tumuenchen ow.ly/5yc650Wos1Y

New study featured on the June cover of Nature Neuroscience used Vizgen’s MERSCOPE® to uncover how microglia and CD8⁺ T cells drive white matter degeneration in aging brains. Learn more: hubs.ly/Q03sqNtp0

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain nature.com/articles/s4159… @NatureNeuro

@RBioceutics No, he is not into bioinformatics.

@GrohJanos did your son do this one too?

Pleased to share our latest work on neural-immune interactions in aging white matter. It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations. Many thanks to everyone involved. nature.com/articles/s4159…

@RBioceutics There is literature that regulatory T cell expansion may be beneficial in this context. Thank you. I can ask him. He will probably ask for a lot of gummy bears.

@GrohJanos Do you think Tregs could inhibit this migration? What a great paper, congratulations. Can your son do the paintings for our papers in the future? I truly loved that story !!

@Ella_Maru Thank you, Ella. Good question. Possibly yes. Resistant microglia downregulate Csf1r and show increased expression of genes encoding alternative receptors that may support their survival (Supplementary Fig. 5d,e).

@GrohJanos Congratulations Janos! Do resistant microglia use non-CSF1R survival programs?

See also this excellent News & Views from Jonathan Monteiro and Veronique Miron. nature.com/articles/s4159…

To start off 2025, we are very pleased to introduce a Special Issue on the Neuroscience of Aging, curated by @AGuskjolen . We hope you enjoy every single piece of it as much as we do! cell.com/neuron/current

@JuliaEdgar1 Thank you Julia! See you soon

Congratulations, Janos

@AOSasmita Thanks Andrew

@GrohJanos Big congrats!! A really nice read

Happy to share this recent review with Mika Simons - White matter aging and its impact on brain function: Neuron cell.com/neuron/fulltex…